Guoxiu Zhang
A5029930625- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Biofuel production and bioconversion
- MicroRNA in disease regulation
- Microbial Metabolic Engineering and Bioproduction
- Cancer-related molecular mechanisms research
- Lipid metabolism and disorders
- Circular RNAs in diseases
- Enzyme Production and Characterization
- COVID-19 and Mental Health
- Transgenic Plants and Applications
- Cardiac Arrest and Resuscitation
- Ultrasound and Hyperthermia Applications
- Healthcare professionals’ stress and burnout
- Ultrasound and Cavitation Phenomena
- Gastrointestinal disorders and treatments
- Renal function and acid-base balance
- Fungal and yeast genetics research
- Sepsis Diagnosis and Treatment
- Copper-based nanomaterials and applications
- Pediatric health and respiratory diseases
- Healthcare Technology and Patient Monitoring
- Dermatological and COVID-19 studies
- ZnO doping and properties
- Inflammasome and immune disorders
First Affiliated Hospital of Henan University of Science and Technology
2015-2025
Chongqing University
2021-2024
Helmholtz-Zentrum Dresden-Rossendorf
2023-2024
Nanjing General Hospital of Nanjing Military Command
2004-2024
Harbin Institute of Technology
2024
Nanjing University
2024
Northeastern University
2022-2023
Henan University of Science and Technology
2014-2020
East China University of Science and Technology
2014-2019
South China Normal University
2019
Previous research has suggested that Xuebijing injection (XBJ), an herbal-based intravenous preparation, may reduce mortality among patients with sepsis.
The incidence of hypertriglyceridemia-associated acute pancreatitis (HTG-AP) is increasing. Plasmapheresis theoretically effective in removing triglyceride from plasma, but whether it confers clinical benefits unclear.To assess the association between plasmapheresis and duration organ failure among patients with HTG-AP.This an a priori analysis data multicenter, prospective cohort study enrolled 28 sites across China. Patients HTG-AP were admitted within 72 hours disease onset. first patient...
Cellulase can convert lignocellulosic feedstocks into fermentable sugars, which be used for the industrial production of biofuels and chemicals. The high cost cellulase remains a challenge lignocellulose breakdown. Trichoderma reesei RUT C30 serves as well-known workhorse production. Therefore, enhancement by T. is great importance.Two sets novel minimal transcriptional activators (DBDace2-VP16 DBDcre1-VP16) were designed expressed in C30. Expression DBDace2-VP16 DBDcre1-VP16 improved under...
Cellulolytic enzymes produced by the filamentous fungus Trichoderma reesei are commonly used in biomass conversion. The high cost of cellulase is still a significant challenge to commercial biofuel production. Improving production T. for application cellulosic biorefinery setting an urgent priority.Trichoderma hyper-cellulolytic mutant SS-II derived from NG14 strain exhibited faster growth rate and more efficient lignocellulosic degradation than those RUT-C30, another NG14. To identify any...
No specific triglyceride-lowering therapy is recommended in patients with hypertriglyceridemia-associated acute pancreatitis (HTG-AP), primarily because of the lack quality evidence. This study aimed to describe practice variations therapies for early HTG-AP and assess whether more rapid triglyceride decline associated improving organ failure. a multicentre, prospective cohort recruiting elevated plasma (> 11.3 mmol/L) admitted within 72 h from onset symptoms. Patients were dichotomised on...
Abstract Filamentous fungi play important roles in the production of plant cell-wall degrading enzymes. In recent years, homologous recombinant technologies have contributed significantly to improved enzymes and system design genetically manipulated strains. When introducing multiple gene deletions, we need a robust convenient way control selectable marker genes, especially when only limited number markers are available filamentous fungi. Integration after transformation is predominantly...
To compare the effect of balanced multielectrolyte solutions (BMESs) versus normal saline (NS) for intravenous fluid on chloride levels and clinical outcomes in patients with predicted severe acute pancreatitis (pSAP). Isotonic crystalloids are recommended initial therapy pancreatitis, but whether use BMES preference to NS confers benefits is unknown. In this multicenter, stepped-wedge, cluster-randomized trial, we enrolled pSAP (acute physiology chronic health evaluation II score ≥8...
During osteoarthritis (OA), chondrocytes become highly active, with increased matrix synthesis and inflammatory cytokine‑induced catabolic pathways. Early intervention strategies targeting pathological changes may attenuate or halt disease progression. The present study aimed to reveal the role of glutathione peroxidase (GPX)7 in OA. For this purpose, a research model was established by inducing C28/I2 human interleukin (IL)‑1β, expression level GPX7 determined. To explore its roles, cells...
Abstract Background Plasmapheresis is widely used for severe hypertriglyceridemia-associated acute pancreatitis (HTG-AP) to remove excessive triglycerides from plasma. This study aimed evaluate whether plasmapheresis could improve the duration of organ failure in HTG-AP patients. Methods We analyzed a cohort patients multicenter, prospective, long-running registry (the PERFORM) collecting admitted sites within 72 h onset symptoms. was based on data collected November 2020 March 2023....
Immune-enhancing thymosin alpha 1 (Tα1) therapy may reduce infected pancreatic necrosis (IPN) in acute necrotising pancreatitis (ANP). However, the efficacy might be impacted by lymphocyte count due to pharmacological action of Tα1. In this post-hoc analysis, we tested hypothesis that pre-treatment absolute (ALC) determines whether patients with ANP benefit from Tα1 therapy. A analysis data a multicentre, double-blind, randomised, placebo-controlled trial testing predicted severe was...
Cellulolytic enzymes produced by Trichoderma reesei are widely used for the industrial production of biofuels and chemicals from lignocellulose. We speculated that intracellular pH during fermentation process can affect cellulase induction. In this study, two H+-ATPase genes, tre76238 tre78757, were first identified in T. reesei. Deletion tre78757 RUT-C30 confirmed has a major function maintaining pH, whereas minor function. The deletion strain Δ76238 displayed high level using...