A5100714645- Spine and Intervertebral Disc Pathology
- Extracellular vesicles in disease
- Pancreatitis Pathology and Treatment
- Cancer, Lipids, and Metabolism
- Cancer-related molecular mechanisms research
- Cholesterol and Lipid Metabolism
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Pregnancy-related medical research
- Glioma Diagnosis and Treatment
- Gastrointestinal disorders and treatments
- Transplantation: Methods and Outcomes
- Ferroptosis and cancer prognosis
- Musculoskeletal pain and rehabilitation
- Lipoproteins and Cardiovascular Health
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Lipid metabolism and biosynthesis
- RNA Interference and Gene Delivery
- Cryptographic Implementations and Security
- Hormonal Regulation and Hypertension
- Circular RNAs in diseases
- Biochemical Analysis and Sensing Techniques
- Congenital heart defects research
Shanghai Changzheng Hospital
2021-2025
Chengdu University of Traditional Chinese Medicine
2025
China Medical University
2024
Second Affiliated Hospital of Jilin University
2015-2024
The Seventh Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2014-2024
Wenzhou Medical University
2024
Obstetrics and Gynecology Hospital of Fudan University
2023-2024
Dalian Ocean University
2024
Second Military Medical University
2011-2023
Osteoarthritis (OA) is a prevalent degenerative joint disease that not only significantly impairs the quality of life middle-aged and elderly individuals but also imposes significant financial burden on patients society. Due to their biological properties, extracellular vesicles (EVs) have steadily received great attention in OA treatment. This study aimed investigate influence EVs chondrocyte proliferation, migration, apoptosis protective efficacy against mice.
Increasing studies have reported that intervertebral disc degeneration (IVDD) is the main contributor and independent risk factor for low back pain (LBP), it would be, therefore, enlightening investigating exact pathogenesis of IVDD developing target-specific molecular drugs in future. Ferroptosis a new form programmed cell death characterized by glutathione (GSH) depletion, inactivation regulatory core antioxidant system (glutathione system) GPX4. The close relationship oxidative stress...
Abstract Low back pain resulting from intervertebral disc degeneration (IVDD) is a prevalent global concern; however, its underlying mechanism remains elusive. Single‐cell sequencing analyses revealed the critical involvement of pyroptosis in IVDD. Considering reactive oxygen species (ROS) as primary instigator and lack an efficient intervention approach, this study developed carbonized Mn‐containing nanodots (MCDs) ROS‐scavenging catalytic biomaterials to suppress nucleus pulposus (NP)...
Cigarette smoking damages the extracellular matrix in a variety of locations, leading to atherosclerotic plaque instability and emphysematous lung destruction, but underlying mechanisms remain poorly understood. Here, we sought determine whether exposure human macrophages, key participant damage, tobacco smoke extract (TSE) induces release microvesicles (MVs; or microparticles) with proteolytic activity; major proteases involved; cellular that might mediate their generation. We found MVs...
Intervertebral disc degeneration (IVDD), a widely known contributor to low back pain (LBP), has been proved be global health challenging conundrum. Hesperidin (hesperetin-7-O-rutinoside, HRD) is flavanone glycoside that belongs the subgroup of citrus flavonoids with therapeutic effect on various diseases due its anti-inflammatory, antioxidant properties. However, HRD IVDD remains elusive. The human nucleus pulposus tissues were harvested for isolating (HNP) cells verify expression Nrf2....
Chronic low back pain (CLBP) has been proved to be the dominating cause of disability in patients with lumbar degenerative diseases. Of various etiological factors, intervertebral disc degeneration (IVDD) cause. In past few decades, role and changes nerve systems, especially peripheral sensory fibers their neurotransmitters, induction progression IVDD have attracted growing concerns. The expression many neuropeptides, such as SP, NPY, CGRP, nociceptive pathways is increased during...
Ropivacaine is a commonly used local anaesthetic, but its side effects remain largely unknown. In the present study, we investigated of ropivacaine in human neuronal SH-5Y5Y cells. We show that 0.5% and 1% could cause fission-like mitochondrial morphological changes. exclusively induces fission protein DRP1, generation ROS causes dysfunction including decreasing membrane potential, activity cytochrome C oxidase ATP production. The appear to be dependent on DRP1 expression as silencing cells...
A population genetic study identified that the asialoglycoprotein receptor 1 (ASGR1) mutation carriers had substantially lower non–HDL-cholesterol (non–HDL-c) levels and reduced risks of cardiovascular diseases. However, mechanism behind this phenomenon remained unclear. Here, we established Asgr1-knockout mice represented a plasma lipid profile with significantly non–HDL-c triglyceride (TG) caused by decreased secretion increased uptake VLDL/LDL. These 2 phenotypes were linked expression...
Background and Objectives: The positive energy balance between caloric intake output increasing storage of triglycerides (TG) in adipocytes has made nonalcoholic fatty liver disease (NAFLD) one the major public health problems China. Excessive lipid deposition pancreas is referred to as (NAFPD). Early assessment pancreatic fat infiltration will have an role clinical management metabolic dysregulation prevention complications. Subjects Methods: We retrospectively collected data inpatients...
Abstract Aims To explore the predictive value of ferroptosis-related (FR) biomarkers for diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM). Methods This prospective observational study enrolled T2DM at Second Hospital Jilin University between December 2021 and March 2022. DKD was measured by urinary albumin-to-creatinine ratio. Receiver operating characteristic curve (ROC) analysis performed to assess DKD.The risk factors massive proteinuria were multivariable...
In fisheries, hypoxia stress is one of the most common environmental stresses that often lead to death large numbers fish and cause significant economic losses. The pituitary, an important endocrine gland, lies below hypothalamus region brain. It plays a crucial part in controlling vital physiological functions fish, such as growth, reproduction, responses stress. However, detailed mechanisms how affects these processes via pituitary remain largely unknown.
Intervertebral disc degeneration (IDD) has been generally accepted as the major cause of low back pain (LBP), which imposes massive clinical and socioeconomic burdens. Previous studies have demonstrated that oxidative stress inflammation-induced senescence apoptosis nucleus pulposus cells (NPCs) are main cellular processes IDD. Arginase II (ARG2), an enzyme involved in a variety pathological processes, including senescence, apoptosis, stress, inflammation, shown to promote several...
Lung adenocarcinoma (LUAD) is the leading cause of cancer death worldwide, with high incidence and low survival rates. Nicotinic acetylcholine receptors play an important role in progression LUAD. In this study, a screening 17 nicotinic receptor allosteric agents revealed that spinosad effectively suppressed proliferation LUAD cells. The experiments demonstrated induced cell cycle arrest G1 phase stimulated apoptosis, thereby impeding growth enhancing responsiveness to gefitinib vitro vivo....
This study aims to explore the application of radiographic imaging and image recognition algorithms, particularly AlexNet ResNet, in classifying malignancies for spinal bone tumors. We selected a cohort 580 patients diagnosed with primary osseous tumors who underwent treatment at our hospital between January 2016 December 2023, whereby 1532 images (679 benign tumors, 853 malignant tumors) were extracted from this dataset. Training validation follow ratio 2:1. All X-ray examinations as part...
Abstract Nucleus pulposus cell (NPC) senescence contributes to intervertebral disc degeneration (IVDD). However, the underlying molecular mechanisms are not fully understood. In this study, it is demonstrated that angiotensin‐converting enzyme 2 (ACE2) counteracted aging of NPCs and IVDD at cellular physiological levels. The expression ACE2 correlates negatively with degree NPC IVDD. Using both loss‐ gain‐of‐function mouse models, revealed deficiency increased exacerbated injury‐ or...
The abnormal activation of the inflammatory microenvironment is frequently accompanied by metabolic changes that affect development various diseases. However, relationship between reprogramming and intervertebral disc degeneration (IVDD) remains unclear. This study aims to reveal in nucleus pulposus (NPCs) during IVDD investigate mechanism glycolysis-derived lactate on NPCs. Single-cell RNA sequencing reveals IVDD, NPCs are characterized excessively elevated glycolysis, resultant causes...
Abstract Background CENP-E, one of spindle checkpoint proteins, plays a crucial role in the function checkpoint. Once CENP-E expression was interrupted, chromosomes can not separate procedurally, and may result aneuploidy which is hallmark most solid cancers, such as hepatocellular carcinoma (HCC). We investigate human carcinoma,. analyze effect low on chromosome separation normal liver cell line (LO2). Methods determined its levels HCC para-cancerous tissues, carcinoma-derived (HepG2) LO2...
Chemokine (C-X-C motif) receptor 4 (CXCR4) has been reported as a poor prognostic biomarker in human breast cancers, and suggested promising therapeutic target of cancer treatment. The present study aims to investigate the delivery efficiency siRNA by chitosan into cells, then examine regulatory role nanoparticle-delivered on CXCR4 expression chemosensitivity cells. Our results demonstrated that could be capsuled nanoparticles with diameter 80–110 nm, zeta potential 20–50 mV. nanoparticle...
Runt-related transcription factor 1 (RUNX1), an essential regulator of hematopoiesis, is overexpressed in patients with nonsmall-cell lung cancer (NSCLC) and correlated enhanced metastatic ability. Ras-interacting protein (Rasip1), a potential oncogene, required for blood vessel formation, recently, it has been shown that Rasip1 widely expressed NSCLC patients. We noticed promoter contains several RUNX1-binding sequences. However, the relationship between RUNX1 still unknown. In this study,...