A5100382086- Immune Cell Function and Interaction
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Cancer Immunotherapy and Biomarkers
- Epigenetics and DNA Methylation
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Genetics and Neurodevelopmental Disorders
- Corneal Surgery and Treatments
- Renal cell carcinoma treatment
- Rheumatoid Arthritis Research and Therapies
- Breast Lesions and Carcinomas
- Breast Cancer Treatment Studies
- Complement system in diseases
- Cytokine Signaling Pathways and Interactions
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Pelvic floor disorders treatments
- Ovarian cancer diagnosis and treatment
- Mesenchymal stem cell research
- Biomarkers in Disease Mechanisms
- Systemic Lupus Erythematosus Research
- Glycogen Storage Diseases and Myoclonus
First Affiliated Hospital of Zhengzhou University
2017-2025
Xinjiang Medical University
2025
Second Affiliated Hospital of Zhejiang University
2024-2025
University of Virginia
2025
Chengdu Third People's Hospital
2023-2024
Nanjing University
2022-2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2024
Wenzhou Medical University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Abstract Background and Aims The study objective was to compare the effectiveness of microwave ablation (MWA) laparoscopic liver resection (LLR) on solitary 3–5‐cm HCC over time. Approach Results From 2008 2019, 1289 patients from 12 hospitals were enrolled in this retrospective study. Diagnosis all lesions based histopathology. Propensity score matching used balance baseline variables between two groups 2008–2019 ( n = 335 each group) 2014–2019 257 cohorts, respectively. For cohort...
The innate immune system is the first line of host defense against infection and involves several different cell types. Here we investigated role phosphatidylinositol 3 kinase (PI3K) signaling pathway in cells. By blocking this with pharmacological inhibitors, found that production proinflammatory cytokines was drastically suppressed monocytes macrophages. Further study revealed suppression mainly related to mammalian target rapamycin (mTOR)/p70S6K signaling. In addition, PI3K involved...
AIM:To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and underlying mechanism. METHODS:Six-week-old male C57BL/6 mice were fed a normal diet or high-fat (HF) for 8 wk.HF dietfed intraperitoneally injected with (30 mg/kg) DMSO (vehicle) once daily week then sacrificed after lipopolysaccharide (LPS, 50 μg/mouse) administration.Hepatic inflammation, levels macrophage marker F4/80,...
Machine learning (ML) algorithms were used to identify a novel biological target for breast cancer and explored its relationship with the tumor microenvironment (TME) patient prognosis. The edgR package identified hub genes associated overall survival (OS) prognosis, which validated using public datasets. Of 149 up-regulated in tissues, three ML COL11A1 as gene. COL11A1was highly expressed samples poor positively correlated stromal score (r=0.49, p<0.001) ESTIMATE (r=0.29, TME....
Biallelic intronic pentanucleotide repeat expansions, mainly (AAGGG)exp and/or (ACAGG)exp in RFC1, are detected cerebellar ataxia, neuropathy and vestibular areflexia syndrome, late-onset a wide disease spectrum including Charcot-Marie-Tooth disease, multiple system atrophy, Parkinson's (PD). However, the genotype-phenotype correlation underlying mechanism mostly unknown. We screened RFC1-repeat expansions 1445 patients with parkinsonism. Comprehensive genetic clinical, pathological...
Abstract Fear and associated learning memory are critical for developing defensive behavior. Excessive fear anxiety important components of post-traumatic stress disorder. However, the neurobiology conditioning, especially tone-related retrieval, has not been clearly defined, which limits specific intervention development patients with excessive anxiety. Here, we show that auditory retrieval stimuli activate multiple brain regions including lateral septum (LS). Inhibition LS connection...
B-1 cells play a critical role in early protection during influenza infections by producing natural IgM antibodies. However, the underlying mechanisms involved regulating this process are largely unknown. Here we found that infection pleural cavity B-1a rapidly infiltrated lungs, where they underwent plasmacytic differentiation with enhanced production. This was promoted IL-17A signaling via induction of Blimp-1 expression and NF-κB activation cells. Deficiency led to severely impaired...
Background/Aims: Increasing evidence suggests that T-UCRs are involved in the development of cancer. In this study, we evaluated role a macrophage-derived T-UCR, uc.306, prognosis hepatitis B (HBV)-related hepatocellular carcinoma (HCC). Methods: The uc.306 was obtained by screening microassay data during polarization U937 cells from M2 to M1 phenotype. Uc.306 and macrophage molecule markers were detected qPCR. Immunohistochemical (IHC) assays used examine M1/M2 status 90 paired HCC tissues....
As one of the most abused illicit drugs, ketamine (KET) has been widely detected in different water environments around globe, which necessitates development effective approaches for KET removal from water. In present study, several novel Ag3PO4/P-g-C3N4 heterojunction composites were successfully constructed using an situ growth method, and samples characterized by a series instruments. The synthesized deployed degradation. Results showed that (1:1) exhibited excellent photocatalytic...
One reason for the poor therapeutic effects of stem cell transplantation in traumatic brain injury is that exogenous neural cells cannot effectively migrate to local site, resulting adhesion and proliferation at injured area. To enhance targeted delivery therapy combined with tissue engineering technology expected become a new strategy treating injury. Collagen/heparan sulfate porous scaffolds, prepared using freeze-drying method, have stable physical chemical properties. These scaffolds...
The nutritional risk index (NRI) is an independent prognostic factor for overall survival in various cancers, but its value breast cancer remains unclear. This study aimed to explore the relationship between NRI and (OS) develop a predictive nomogram.We retrospectively enrolled 1347 patients who underwent mastectomy or lumpectomy January 2011 November 2012. Using cutoff of 110.59, were divided into high-NRI group low-NRI group. OS was compared two groups. Clinicopathological factors...
Background Multiple clinical studies have found a significant correlation between elevated galectin-3 (Gal-3) in circulation and the diagnosis severity of peripheral arterial disease (PAD). The current study used Mendelian randomization (MR) technique to evaluate possible causal relationship Gal-3 PAD. Methods Genome-wide association (GWAS) data PAD were obtained through MR-Base platform. Then, using as exposure outcome, two-sample MR analysis was performed utilizing several regression...
Pancreatic cancer (PC) is one of the leading causes cancer, with lowest 5-year survival rate all types. Given fast metastasis PC and its resistance to surgery, radiotherapy, chemotherapy, combinations thereof, it imperative develop more effective anti-PC drugs. Phillygenin (PHI) has been reported exert anti-cancer, anti-bacterial, anti-inflammatory properties. However, mechanism PHI in development still unclear.The cytotoxicity pancreatic cells was evaluated by MTT assay, clonogenic assay...
Two-dimensional ultrasound (US) and color doppler flow imaging are associated with certain limitations in the preprocedural evaluation design of puncture path for biopsies thoracic lesions, such as a poorly defined boundary between tumor atelectatic lesions central lung cancer atelectasis. Contrast-enhanced (CEUS) can be valuable preoperative biopsy site increasing accuracy biopsy. The present study investigated value clinical application CEUS US-guided core needle (US-CNB) improving...
Abstract A wide variety of stimuli have been shown to induce inflammation, but bacteria products/components are considered the major inducers during bacterial infections. We previously demonstrated that such as LPS, a glycolipid component outer membrane, and formylated peptides (fMLP), bacterial-derived peptide, induced proinflammatory cytokine gene expression in human peripheral blood monocytes. now present evidence mixtures LPS fMLP behave synergistically induction inflammation vitro vivo....
Leukocyte immunoglobulin-like receptor subfamily B (LILRB), including 5 subtypes, is a group of inhibitory receptors in the immune system. The LILRB family known to be involved tumor progression various cancer types, especially liver cancer. However, expression patterns and prognostic values members tissues remain unclear.We used Oncomine database, GEPIA Kaplan-Meier Plotter, Timer, TISIDB assess value patients. We also verified tumor-free at protein level by using immunohistochemistry....