A5100635648- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Biological and pharmacological studies of plants
- Spectroscopy Techniques in Biomedical and Chemical Research
- Drug Transport and Resistance Mechanisms
- Plant tissue culture and regeneration
- Parkinson's Disease Mechanisms and Treatments
- Angiogenesis and VEGF in Cancer
- Tissue Engineering and Regenerative Medicine
- Bladder and Urothelial Cancer Treatments
- Drug-Induced Hepatotoxicity and Protection
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Winter Sports Injuries and Performance
- Esophageal and GI Pathology
- Thyroid Cancer Diagnosis and Treatment
- Molecular Communication and Nanonetworks
- Parkinson's Disease and Spinal Disorders
- Pharmacological Effects of Natural Compounds
- Hemostasis and retained surgical items
- Ginseng Biological Effects and Applications
- Ginkgo biloba and Cashew Applications
- Viral-associated cancers and disorders
- Arsenic contamination and mitigation
- Microbial Inactivation Methods
Hainan Medical University
2018-2025
Northeastern University
2020-2024
University of Southern California
2024
Beijing University of Chinese Medicine
2024
Southern Medical University
2024
Nanfang Hospital
2024
Weatherford College
2023
Meizhou City People's Hospital
2021-2023
Pius Hospital Oldenburg
2022
Kunming Institute of Botany
2022
Machine learning (ML) algorithms were used to identify a novel biological target for breast cancer and explored its relationship with the tumor microenvironment (TME) patient prognosis. The edgR package identified hub genes associated overall survival (OS) prognosis, which validated using public datasets. Of 149 up-regulated in tissues, three ML COL11A1 as gene. COL11A1was highly expressed samples poor positively correlated stromal score (r=0.49, p<0.001) ESTIMATE (r=0.29, TME....
Despite the advantages of endoscopic surgery in reducing trauma and enhancing recovery for breast cancer patients, its impact on gut microbiota, which is crucial health estrogen metabolism, remains unclear. Further investigation necessary to fully understand this implications. Between June December 2022, fecal samples were collected from 20 patients who underwent surgery. The microbiota composition was determined using 16S rRNA sequencing, while metabolites analyzed through liquid...
To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset progression of Parkinson's disease (PD) through integrative proteomic genetic analyses. We utilized large-scale plasma brain quantitative trait loci (pQTL) datasets from deCODE Health study Religious Orders Study/Rush Memory Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using OTTERS framework proteins FUSION tool proteins,...
Background and Purpose The aim of this study was to investigate the ameliorative effects corilagin on intrahepatic cholestasis induced by regulating liver farnesoid X receptor (FXR)‐associated pathways in vitro vivo . Experimental Approach Cellular animal models were treated with different concentrations corilagin. In cellular experiments, FXR expression up‐regulated either lentiviral transduction or GW4064 treatment down‐regulated siRNA technology guggulsterones. Real‐time PCR Western...
Aristolochic acids (AAs) contained in herbal plants are implicated multiple organ injuries and have a high mutational burden upper tract urothelial cancers. The currently available techniques for monitoring AAs include LC (liquid chromatography) LC/MS (mass spectrometry), but the application of these approaches limited due to complex sample preparation derivatization steps. Therefore, there is an urgent need develop efficient methods identifying quantifying AAs. Here, we present new...
Bile salt export pump (BSEP) have been confirmed to play an important role for bile acid canalicular in the treatment of cholestasis. In this study, we investigated stimulatory effect emodin on BSEP signaling pathway cholestasis.Cell and animal experiments were given different concentrations emodin. The upstream molecule farnesoid X receptor was down-regulated by small interfering RNA (siRNA) technology or guggulsterones up-regulated lentivirus GW4064. Real-time PCR Western blotting employed...
The infiltration of CD8 T cells is usually linked to a favorable prognosis and may predict the therapeutic response breast cancer patients immunotherapy. purpose this research investigate competing endogenous RNA (ceRNA) network correlated with cells.Based on expression profiles, cell abundances for each (BC) patient were inferred using bioinformatic method by immune markers profiles. We able extract differentially expressed RNAs (DEmRNAs, DEmiRNAs, DElncRNAs) between low high T-cell...
Abstract Chemotherapy is an important therapuetic strategy for colorectal cancer (CRC), but chemoresistance severely affects its efficacy, and the underlying mechanism has not been fully elucidated. Increasing evidence suggests that lipid peroxidation imbalance-mediated ferroptosis closely associated with chemoresistance. Hence, targeting pathways or modulating tolerance to oxidative stress might be effective reverse tumor HtrA serine protease 1 (HTRA1) was screened out as a CRC progression-...
Abstract Background Neonatal Bacillus C almette– G uérin ( BCG ) vaccination induces vigorous T‐helper type 1 Th 1) responses and inhibits allergy‐related airway dysfunction, but the exact mechanisms remain unclear. The objective of this study was to address where cells induced by neonatal are generated stored, how they recruited into inflamed for prevention allergen‐induced inflammation. Methods We vaccinated C57 BL /6 mice with in a mouse model asthma analyzed expression function vivo...
Non-muscle-invasive bladder cancer (NMIBC) is a common urinary tumor and has high recurrence rate due to improper or inadequate conservative treatment. The early accurate prediction of its can be helpful implement timely rational In this study, we explored preoperative serum surface-enhanced Raman spectroscopy based prognostic protocol predict the postoperative prognosis for NMIBC patients at time even before biochemical analysis results suggested that biomolecules related DNA/RNA, protein...
This study aims to develop and validate a machine learning (ML) predictive model for assessing mortality in patients with malignant tumors hyperkalemia (MTH). We extracted data on MTH from the Medical Information Mart Intensive Care-IV, version 2.2 (MIMIC-IV v2.2) database. The dataset was split into training set (75%) validation (25%). used Least Absolute Shrinkage Selection Operator (LASSO) regression identify potential predictors, which included clinical laboratory indicators vital signs....
MicroRNAs (miRs) are endogenous, single-stranded, noncoding RNAs that involved in various physiological processes, and the development progression of types cancer. Specifically, role miR-200a-3p has been implicated cancer contributing to a diverse array previously reported. The present study aimed investigate expression levels human bladder cancer, as well its potential disease pathogenesis.Reverse transcription-polymerase chain reaction (RT-PCR) Western blot were used detect has-mir-200a-3p...
Background and purpose: It remains unclear about the etiopathogenesis of cognitive impairment (CI) in Parkinson's disease (PD). Since diabetes mellitus (DM) has been shown to be associated with CI several diseases, we examined association between dysglycemia PD. Methods: Enrolled PD patients completed a series clinical neuropsychological assessments. Motor symptoms were determined by Hohen-Yahr staging (H-Y staging) Unified Disease Rating Scale - motor score (UPDRS-III). Neuropsychological...
Abstract The orchid Dendrobium officinale grows throughout southeast China and Asian countries is used to treat inflammation diabetes in traditional Chinese medicine. Tie pi feng dou a well-known medicine made from the dried D. stems. Processing alters physicochemical properties of TPFD; however, it unclear how processing affects quality medicinal value this plant. Here, we analyzed compared chemical composition fresh stems TPFD explored possible explanations for enhanced efficacy processed...
Abstract Nonviral targeting technology has become promising as a form of gene therapy for diseases and injuries, such Achilles tendon injuries. In this study, we used avidin–biotin bridge positive–negative charge attractions to load the intercellular adhesion molecule-1 (ICAM-1) antibody basic fibroblast growth factor (bFGF) plasmid onto surface microbubbles. The saturated loading capacity 1.1 × 10 8 microbubble was 6.55 ± 0.53 µg. We established ICAM-1 antigen microenvironment using tumor...
Bladder cancer (BC) is a common urologic tumor with high recurrence rate. Cuproptosis and long noncoding RNAs (lncRNAs) have demonstrated essential roles in the tumorigenesis of many malignancies. Nevertheless, prognostic value cuproptosis-related lncRNA (CRLs) BC still unclear. The public data used for this study were acquired from Cancer Genome Atlas database. A comprehensive exploration expression profile, mutation, co-expression, enrichment analyses genes was performed. total 466 CRLs...