A5051734663- Plant Molecular Biology Research
- Epigenetics and DNA Methylation
- Plant nutrient uptake and metabolism
- Barrier Structure and Function Studies
- Hydrocarbon exploration and reservoir analysis
- Enhanced Oil Recovery Techniques
- Genetic Syndromes and Imprinting
- Petroleum Processing and Analysis
- Neurological Disease Mechanisms and Treatments
- Caveolin-1 and cellular processes
- Cerebrovascular and genetic disorders
- Nutrition, Genetics, and Disease
- Plant Gene Expression Analysis
- Diet and metabolism studies
- Lipid metabolism and biosynthesis
- Plant biochemistry and biosynthesis
- Neuroinflammation and Neurodegeneration Mechanisms
- Cell Adhesion Molecules Research
- Catalytic Processes in Materials Science
- Photosynthetic Processes and Mechanisms
- Mitochondrial Function and Pathology
- Plant Stress Responses and Tolerance
- Plant tissue culture and regeneration
- Alzheimer's disease research and treatments
- Genetic Associations and Epidemiology
Henan Provincial People's Hospital
2021-2025
Zhengzhou University
2019-2025
China University of Petroleum, Beijing
2023-2024
Northwest A&F University
2016-2024
Lanzhou University of Technology
2024
Sun Yat-sen University
2021-2023
Shanghai Polytechnic University
2022
Henan Academy of Sciences
2022
Nanjing University of Posts and Telecommunications
2022
Henan University
2021
In many higher plants, seed oil accumulation is precisely controlled by intricate multilevel regulatory networks, among which transcriptional regulation mainly influences biosynthesis. Arabidopsis (Arabidopsis thaliana), the master positive transcription factors, WRINKLED1 (WRI1) and LEAFY COTYLEDON1-LIKE (L1L), are important for accumulation. We found that an R2R3-MYB factor, MYB89, was expressed predominantly in developing seeds during maturation. Oil major fatty acid biosynthesis...
Chronic cerebral hypoperfusion (CCH) is the leading cause of small vessel disease (CSVD). CCH strongly associated with blood-brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, effects on BBB integrity components cellular molecular mechanisms underlying remain elusive. Whether maintaining can reverse CCH-induced brain damage has also not been explored.In this study, we established a rat model CSVD via permanent bilateral common carotid artery occlusion (2VO) to...
To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset progression of Parkinson's disease (PD) through integrative proteomic genetic analyses. We utilized large-scale plasma brain quantitative trait loci (pQTL) datasets from deCODE Health study Religious Orders Study/Rush Memory Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using OTTERS framework proteins FUSION tool proteins,...
GRN mutations act as causative factors in patients with FTD clinical phenotype or pathology and exhibit high heterogeneity. The discovery of these the analysis their associations resembling Alzheimer's disease should be critical to understand pathogenesis FTD. Clinical analysis, neuroimaging, target region capture high-throughput sequencing were performed a family 3 generations. underlying was evaluated by using biomarker evidence obtained from cerebrospinal fluid (CSF) amyloid testing,...
The MYB family of transcription factors is important in regulatory networks controlling development, metabolism and responses to biotic abiotic stresses Arabidopsis. However, their role regulating fatty acid accumulation seeds still largely unclear. Here, we found that MYB76, localized the nucleus, was predominantly expressed developing during maturation. myb76 mutation caused a significant increase amounts total acids several major compositions mature seeds, suggesting MYB76 functioned as...
Introduction: Spinocerebellar ataxias 36 (SCA36) is the neurodegenerative disease caused by GGCCTG Hexanucleotide repeat expansions in NOP56 , which too long to sequence using short-read sequencing. Single molecule real time (SMRT) sequencing can across disease-causing expansion. We report first long-read data expansion region SCA36. Methods: collected and described clinical manifestations imaging features of Han Chinese pedigree with three generations Also, we focused on structural...
SUMMARY Leaves, as primary photosynthetic organs essential for high crop yield and quality, have attracted significant attention. The functions of DNA topoisomerase 1α (TOP1α) in various biological processes, including leaf development, Brassica napus remain unknown. Here, four paralogs BnaTOP1α , namely BnaA01.TOP1α BnaA02.TOP1α BnaC01.TOP1α BnaC02.TOP1α were identified cloned the B. inbred line ‘K407’. Expression pattern analysis revealed that but not persistently highly expressed true...
Blood-brain barrier (BBB) dysfunction plays a pivotal role in the pathology of chronic cerebral hypoperfusion (CCH)-related neurodegenerative diseases. Continuous endothelial cells (EC) that line blood vessels brain are important components BBB to strictly control flow substances and maintain homeostatic environment brain. However, molecular mechanisms from perspective EC-induced after CCH largely unknown. In this study, function was assessed using immunostaining transmission electron...
Previous studies have shown that several ACYL-ACYL CARRIER PROTEIN DESATURASE (AtAAD) members in Arabidopsis thaliana are responsible for oleic acid (C18:1) biosynthesis. Limited research has been conducted on another member, AtAAD5, and its paralog BnAAD5 the closely related commercially important plant, Brassica napus. Here, we found AtAAD5 was predominantly exclusively expressed developing embryos at whole seed developmental stages. The aad5 mutation caused a significant decrease amounts...
Background: Chronic cerebral hypoperfusion (CCH) is associated with neuronal loss and blood-brain barrier (BBB) impairment in vascular dementia (VaD). However, the relationship molecular mechanisms between BBB dysfunction remain elusive. Objective: We explored reasons for neuron following CCH. Methods: Using permanent bilateral common carotid artery occlusion (2VO) rat model, we observed pathological changes of cortical neurons sham group as well rats 3d, 7d, 14d 28d post 2VO. In order to...
The blood-brain barrier (BBB) comprises a single layer of endothelial cells and maintains safe homeostatic environment for proper neuronal function synaptic transmission. BBB is not discrete physical barrier, but complex, dynamic, adaptable interface. continues to mature under the influence neural within short period time after birth. However, basic mechanism formation maintenance remains mystery. Early studies have identified two structural characteristics microvascular endothelium: special...
parent-of-origin effects (POE) play important roles in complex disease and thus understanding their regulation associated molecular phenotypic variation are warranted. Previous studies mainly focused on the detection of genomic regions or phenotypes regulated by POE. Understanding whether POE may be modified environmental genetic exposures is for source POE-associated variation, but only a few case addressing modifiable exist.
Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) caused by NOTCH3 mutations is the most common monogenic hereditary pattern of cerebral small vessel disease. The aggregation mutant may play a cytotoxic role in CADASIL. However, main mechanism this process remains unclear. Objective: We aimed to investigate possible pathogenesis Methods: clinical information two pedigrees were collected analyzed. Furthermore, we constructed cell...