A5048859853- Neuroinflammation and Neurodegeneration Mechanisms
- Barrier Structure and Function Studies
- Mitochondrial Function and Pathology
- Neurological Disease Mechanisms and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Metabolism and Genetic Disorders
- Pancreatitis Pathology and Treatment
- Acute Ischemic Stroke Management
- ATP Synthase and ATPases Research
- Heat shock proteins research
- Ferroptosis and cancer prognosis
- Liver Disease Diagnosis and Treatment
- Viral Infections and Immunology Research
- Dialysis and Renal Disease Management
- Sphingolipid Metabolism and Signaling
- Cholinesterase and Neurodegenerative Diseases
- Parathyroid Disorders and Treatments
- Alzheimer's disease research and treatments
- Eicosanoids and Hypertension Pharmacology
- Ion Transport and Channel Regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuroscience and Neuropharmacology Research
- Signaling Pathways in Disease
- Inflammatory Biomarkers in Disease Prognosis
- Medicinal Plants and Bioactive Compounds
Zhengzhou University
2021-2024
Changhai Hospital
2023-2024
Second Military Medical University
2023-2024
Henan Provincial People's Hospital
2021-2023
Henan University
2021-2022
Ministry of Education of the People's Republic of China
2022
Chinese Institute for Brain Research
2022
Capital Medical University
2017-2022
National Clinical Research Center for Digestive Diseases
2022
Chronic cerebral hypoperfusion (CCH) is the leading cause of small vessel disease (CSVD). CCH strongly associated with blood-brain barrier (BBB) dysfunction and white matter lesions (WMLs) in CSVD. However, effects on BBB integrity components cellular molecular mechanisms underlying remain elusive. Whether maintaining can reverse CCH-induced brain damage has also not been explored.In this study, we established a rat model CSVD via permanent bilateral common carotid artery occlusion (2VO) to...
Abstract Glioblastomas (GBM) is the most common primary malignant brain tumor, and radiotherapy plays a critical role in its therapeutic management. Unfortunately, development of radioresistance universal. Here, we identified calcium-regulated heat-stable protein 1 (CARHSP1) as driver for utilizing genome-wide CRISPR activation screening. This with cold-shock domain (CSD)-containing that highly similar to proteins. CARHSP1 mRNA level was upregulated irradiation-resistant GBM cells knockdown...
Abstract Background Peritoneal dialysis (PD) remains limited due to failure caused by peritoneal fibrosis. Tamoxifen (TAM), an inhibitor of estrogen receptor 1 (ESR1), has been reported treat fibrosis, but the underlying mechanism unknown. In this study, we sought explore whether tamoxifen played anti-fibrotic role affecting transcription factor ESR1. Methods ESR1 expression was detected in human peritoneum. Mice were daily intraperitoneally injected with 4.25% glucose PD dialysate...
Abstract Long‐term exposure to non‐physiologically compatible dialysate inevitably leads peritoneal fibrosis (PF) in patients undergoing dialysis (PD), and there is no effective prevention or treatment for PF. Sphingosine‐1‐phosphate (S1P) a bioactive sphingolipid produced after catalysis by sphingosine kinase (SPHK) 1/2 activates signals through the S1P receptor (S1PR) via autocrine paracrine. However, role of SPHK1/S1P/S1PR signaling has never been elucidated In our research, we...
Ischemic stroke often induces profound white matter lesions, resulting in poor neurological outcomes and impaired post-stroke recovery. The present study aimed to investigate the effects of cornel iridoid glycoside (CIG), a major active component extracted from Cornus officinalis, on injury induced by ischemic further its neuroprotective mechanisms.Adult male Sprague-Dawley rats underwent middle cerebral artery occlusion (MCAO) surgery for 2 h, followed reperfusion. Rats were...
Schizophrenia is a psychiatric disorder including multiple clinical symptoms such as severe psychosis and cognitive dysfunction. DHF-7 novel dihydroflavanone derivative that was designed synthesized to treat schizophrenia. This study aimed investigate the effects mechanisms of in mouse model schizophrenia induced by combination cuprizone MK-801.After intragastric administration for 7 weeks, open field, Y-maze, object recognition tests were performed detect behavioral changes model. White...
Stroke-induced heart syndrome is a feared complication of ischemic stroke, that commonly encountered and has strong association with unfavorable prognosis. More research needed to explore underlying mechanisms inform clinical decision making. This study aims the relationship between early systemic immune-inflammation (SII) index cardiac complications after acute stroke. Consecutive patients stroke were prospectively collected from January 2020 August 2022 retrospectively analyzed. We...
Abstract Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, about 10% of AD patients are called early-onset familial (EOFAD), which mainly linked to the point mutations in genes encoding Presenilins ( PS1 and PS2 ). Mutations extremely rare have not received enough attention. Recently studies found that Rho GTPase was closely related pathogenesis AD. In this study, we used transcriptome sequencing siRNA SH-SY5Y cells a group differential expression (DEGs) play...
Abstract Background: Chronic cerebral hypoperfusion (CCH) is the leading cause for small vessel disease (CSVD). CCH strongly associated with blood–brain barrier (BBB) dysfunction and white matter lesions (WML) in CSVD. But effects of on BBB integrity constituents as well cellular molecular mechanisms about consequences remain elusive. Whether maintaining can reverse induced brain damage has also not been explored. Methods: In this study, we used a rat model CSVD, established via permanent...