A5059433438- Tryptophan and brain disorders
- Genetic Associations and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological diseases and metabolism
- 2D Materials and Applications
- Parkinson's Disease Mechanisms and Treatments
- Gene expression and cancer classification
- Immunodeficiency and Autoimmune Disorders
- Bladder and Urothelial Cancer Treatments
- interferon and immune responses
- Autoimmune Bullous Skin Diseases
- Nuclear Receptors and Signaling
- IL-33, ST2, and ILC Pathways
- Organ Transplantation Techniques and Outcomes
- Nanowire Synthesis and Applications
- Colorectal and Anal Carcinomas
- Renal Transplantation Outcomes and Treatments
- Perovskite Materials and Applications
- Helicobacter pylori-related gastroenterology studies
- Bioinformatics and Genomic Networks
- Gastric Cancer Management and Outcomes
- Gastroesophageal reflux and treatments
- MicroRNA in disease regulation
- Gastrointestinal Tumor Research and Treatment
- Hypertrophic osteoarthropathy and related conditions
Guangzhou Medical University
2022-2025
Second Affiliated Hospital of Guangzhou Medical University
2022-2025
Shenzhen University
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2024
Peking Union Medical College Hospital
2024
Third Affiliated Hospital of Guangzhou Medical University
2022
Background: Recent studies have linked atopic dermatitis (AD) to colorectal cancer (CRC) risk.Their causality and potential molecular mechanisms remain unclear.Methods: We performed Mendelian randomization (MR) analysis evaluate the between AD CRC.Summary statistic data-based (SMR) was used identify CRC-related causal genes.Transcriptome analyses immunohistochemical methods were applied investigate shared gene signature that contribute pathogenesis of both CRC.A predictive examine associated...
Alzheimer's disease (AD) has a significant impact on an individual's health and places heavy burden society. Studies have emphasized the importance of microglia in progression development AD. Interferon responses Interferon-stimulated genes (ISGs) significantly function neuroinflammatory neurodegenerative diseases involving Therefore, further exploration relationship among microglia, ISGs, neuroinflammation AD is warranted. Microglia datasets from GEO database were retrieved, along with...
To identify and validate causal protein targets that may serve as potential therapeutic interventions for both the onset progression of Parkinson's disease (PD) through integrative proteomic genetic analyses. We utilized large-scale plasma brain quantitative trait loci (pQTL) datasets from deCODE Health study Religious Orders Study/Rush Memory Aging Project (ROS/MAP), respectively. Proteome-wide association studies (PWAS) were conducted using OTTERS framework proteins FUSION tool proteins,...
Males have a three times higher risk of diagnosis bladder cancer (Bca) than females. Sex hormone-binding globulin (SHBG) may be associated with Bca risk. However, the sex-specific role SHBG in remains unclear. In this study, we aimed to determine Bca. A univariable Mendelian randomization (MR) analysis involving 369,426 men and 395,375 women was conducted assess causal relationship between testosterone Sensitivity analyses multivariable MR were confirm robustness our results. Linkage...
Stacked semiconducting nanosheets (SSNs), which feature strong in-plane covalent bonds but weak van der Waals (vdWs) interactions between adjacent layers, hold substantial promise in next-generation, printable, and flexible devices. Among them, SSN-based transistors with high current multiplication offer significant potential for large-area, high-integration electronics biomedical applications. However, the three-terminal configuration of transistor inevitably increases process step power...
Chronic enteropathy associated with the
Parkinson's disease (PD) is a common degenerative nervous system disease. At present, there are certain limitations in various treatment options aimed at preventing or delaying the progression of PD. Therefore, exploration new drugs for PD beneficial. Mendelian randomization (MR) analysis can be used to explore association between and diseases. In this study, MR was adopted investigate causal relationship 23 These have been approved different diseases, such as salicylic acid derivatives...
Ambipolar transistors from low-dimensional semiconductors with high charge-transporting capability and tunable bandgap have developed rapidly in functional applications, such as neuromorphic computing, lighting, storing, sensing. However, there are still challenges to balance procedure complexity device performance, current on–off ratio, work voltage, operational reliability. Here, we demonstrated solution-processed ambipolar ionic-gated (amIGTs) stacked heterojunctions of 1D/2D SnO2/Se...
Renal transplantation can significantly improve the survival rate and quality of life patients with end-stage renal disease, but probability acute rejection (AR) in adult transplant recipients is still approximately 12.2%. Machine learning (ML) superior to traditional statistical methods various clinical scenarios. However, current AR model constructed only through simple difference analysis or a single queue, which cannot guarantee accuracy prediction. Therefore, this study identified...
Though the survival benefit of primary tumor operation for patients with signet ring cell carcinoma stomach is known, specific characteristics those who would profit from are yet to be determined. To this end, a predictive model was developed identify conjecture that only obtained by patients.The clinical data were Surveillance, Epidemiology, and End Results database, then divided into no-operation groups based on whether underwent operation. remove confounding factors, propensity score...
Studies have demonstrated that microglia play a key role in the progression and deterioration of Alzheimer's disease (AD). In addition, genes associated with interferon function been identified as trans-acting targets AD susceptibility loci pose risk factors for AD. Therefore, further exploration relationship between microglia, ISGs, is warranted. We used bioinformatics machine learning algorithms to screen potential interferon-related diagnostic candidate gene oas1g from microglial...