A5018155493- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Renal and related cancers
- Cancer-related molecular mechanisms research
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Kidney Stones and Urolithiasis Treatments
- Renal cell carcinoma treatment
- Cancer, Lipids, and Metabolism
- MicroRNA in disease regulation
- Pediatric Urology and Nephrology Studies
- Pelvic floor disorders treatments
- Urinary Bladder and Prostate Research
- Childhood Cancer Survivors' Quality of Life
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- Urinary and Genital Oncology Studies
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Transportation and Mobility Innovations
- Cyclone Separators and Fluid Dynamics
- Nanocluster Synthesis and Applications
- Artificial Intelligence in Healthcare
- Psoriasis: Treatment and Pathogenesis
Sun Yat-sen University
2021-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2021-2024
Nanjing University of Posts and Telecommunications
2023
Shenzhen Institutes of Advanced Technology
2023
Chinese Academy of Sciences
2023
Guangzhou Medical University
2018-2021
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2021
Hebei University of Technology
2019
Previous studies have reported an inconsistent relationship between overactive bladder (OAB) and the consumption of tea, coffee, caffeine. Our study aims to determine these associations in a large nationally representative adult sample.
This study investigates the association between exposure to environmental pollutants—perchlorate, nitrate, and thiocyanate (PNT)—and prevalence of kidney stone disease (KSD) in US adults, utilizing data from National Health Nutrition Examination Survey (NHANES) 2007–2018. With increasing incidence KSD, understanding risk factors has become crucial. While PNT compounds are known be associated with various health issues, their role KSD remains unclear. A cross-sectional analysis 11,350...
Abstract Objectives To determine whether relationship exists between overactive bladder (OAB) and sleep patterns through the cross-sectional study. Patients methods from National Health Nutrition Examination Survey (NHANES) 2007–2014 were included in this Data extracted questionnaires, including demographics, dietary health-related behaviors, body measurements disease information. Three factors to aggregate overall scores, ranging 0 3. A score of 1, 2 or 3 was expressed as a bad,...
Bladder cancer (BC) is the most common malignancy in urinary system and prone to recurrence metastasis. Pyroptosis a kind of cell necrosis that triggered by gasdermin protein family. lncRNAs are noncoding RNAs more than 200 nucleotides long. Both pyroptosis associated with tumor development progression. This study aimed at exploring establishing prognostic signature BC based on pyroptosis-related lncRNAs. In this study, The Cancer Genome Atlas (TCGA) database provided us RNA sequencing...
The biomarkers have an important guiding role in prognosis and treatment of patients with bladder cancer (BC). aim the present study was to identify evaluate a prognostic gene signature BC patients. expression profiles samples corresponding clinicopathological data were downloaded from GEO TCGA. differentially expressed genes (DEGs) identified by R software. Univariate Cox regression least absolute shrinkage selection operator (LASSO) applied construct score model. A nomogram established...
This study is aimed at constructing and verifying nomograms that forecast overall survival (OS) cancer-specific (CSS) of children with Wilms' tumor (WT). Clinical information 1613 WT patients who were under 18 years old between 1988 2010 was collected from the Surveillance, Epidemiology, End Results (SEER) database. Using these data, we performed univariate as well multivariate Cox's regression analyses to determine independent prognostic factors for WT. Then, predict 3- 5-year OS CSS rates...
The primary subtypes of renal cell carcinoma (RCC) include clear cell, papillary and chromophobe RCC. RCC occurs often due to loss von Hippel‑Lindau (VHL) accumulation lipids glycogen, cells may exhibit sensitivity the disruption normal metabolism or homologous recombination gene defect. Although application molecular‑targeted drugs (tyrosine kinase inhibitors) immune checkpoint inhibitors has been recommended for treatment advanced RCC, more targets DNA damage repair (DDR) signaling pathway...
The purpose of the present study was to identify key genes and investigate related molecular mechanisms bladder cancer (BC) progression. From Gene Expression Omnibus database, gene expression dataset GSE7476 downloaded, which contained 43 BC samples 12 normal tissues. analyzed screen differentially expressed (DEGs). Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses were performed for DEGs using DAVID a protein‑protein interaction (PPI) network then constructed Cytoscape...
To predict survival outcomes for individual patients with clinical T1 high‑grade (T1HG) bladder cancer (BC), data from the Surveillance Epidemiology and End Results (SEER) database were analyzed in present study. The of 6,980 cases T1HG BC between 2004 2014 obtained SEER database. Uni‑ multivariate Cox analyses performed to identify significant prognostic factors. Subsequently, nomograms predicting 3‑ 5‑year overall (OS) cancer‑specific (CSS) rates constructed based on Clinical information...
Abstract Background Competitive endogenous RNAs (ceRNAs) have revealed a new mechanism of interaction between RNAs. However, an understanding the ceRNA regulatory network in Wilms tumour (WT) remains limited. Methods The expression profiles mRNAs, miRNAs and lncRNAs samples normal were obtained from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database. EdgeR package was employed identify differentially expressed lncRNAs, mRNAs. Functional enrichment analyses...
Background: Evidence increasingly indicates that HPV infection plays a pivotal role in the initiation and progression of bladder cancer (BC). Yet, determining predictive value HPV-associated genes BC remains challenging. Methods: We identified differentially expressed patients from TCGA GEO databases. screened prognostic using COX LASSO regression, subsequently establishing risk prediction model. The model's precision clinical relevance were gauged Kaplan-Meier survival analyses ROC curves....
Abstract Bladder cancer (BLCA) is a common and difficult‐to‐manage disease worldwide. Most type of BLCA urothelial carcinoma (UC). Fibrillin 2 (FBN2) was first discovered while studying Marfan syndrome, its encoded products are associated with elastin fibres. To date, the role FBN2 in remains unclear. The authors downloaded data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). patients were divided into high expression low groups, survival curve, clinical characteristics,...
Renal transplantation can significantly improve the survival rate and quality of life patients with end-stage renal disease, but probability acute rejection (AR) in adult transplant recipients is still approximately 12.2%. Machine learning (ML) superior to traditional statistical methods various clinical scenarios. However, current AR model constructed only through simple difference analysis or a single queue, which cannot guarantee accuracy prediction. Therefore, this study identified...
Background: As an epigenetic alteration, DNA methylation plays important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis classification of tumor heterogeneity. Methods: Methylation data, RNA-sequencing (RNA-seq) corresponding clinical information were downloaded from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. The prognostic values subtypes identified. Results: Four patients identified by consensus cluster...
Wilms tumor (WT) is a common pediatric renal cancer, with poor prognosis and high-risk recurrence in some patients. The inflammatory microenvironment gradually gaining attention WT. In this study, novel inflammation-related signatures prognostic model were explored integrated using bioinformatics analysis. mRNA profile of patients WT genes (IRGs) acquired from Therapeutically Available Research to Generate Effective Treatments (TARGET) Gene Set Enrichment Analysis (GSEA) databases,...
Introduction: Psoriasis is a chronic, inflammatory, and papulo-squamous skin disorder without radical cure. Although previous observational analyses have discovered relationship between medication intake increased risk of psoriasis, they are susceptible to confounders. Objectives: We intend ascertain if there causal association specific psoriasis by utilizing the Mendelian randomization (MR) method. Methods: obtained genome-wide study (GWAS) data for (23 types, N = 1809) from UK Biobank...
Background Kidney stone disease (KSD) is a widespread problem in urology. But the associations between Geriatric Nutritional Risk Index (GNRI), an important indicator for assessing nutritional status of elderly hospitalized patients, and KSD are understudied. Objective Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2007–2018, our study analyzed correlation GNRI prevalence at cross-sectional level. The aim was to explore association identify potential risk...
Abstract Background: Competitive endogenous RNAs (ceRNAs) have revealed a new mechanism of interaction between RNAs. However, an understanding the ceRNA regulatory network in Wilms tumour (WT) remains limited.Methods: The expression profiles mRNAs, miRNAs and lncRNAs samples normal were obtained from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database. EdgeR package was employed identify differentially expressed lncRNAs, mRNAs. Functional enrichment analyses...