This study investigates the association between exposure to environmental pollutants—perchlorate, nitrate, and thiocyanate (PNT)—and prevalence of kidney stone disease (KSD) in US adults, utilizing data from National Health Nutrition Examination Survey (NHANES) 2007–2018. With increasing incidence KSD, understanding risk factors has become crucial. While PNT compounds are known be associated with various health issues, their role KSD remains unclear. A cross-sectional analysis 11,350...

The biomarkers have an important guiding role in prognosis and treatment of patients with bladder cancer (BC). aim the present study was to identify evaluate a prognostic gene signature BC patients. expression profiles samples corresponding clinicopathological data were downloaded from GEO TCGA. differentially expressed genes (DEGs) identified by R software. Univariate Cox regression least absolute shrinkage selection operator (LASSO) applied construct score model. A nomogram established...

The primary subtypes of renal cell carcinoma (RCC) include clear cell, papillary and chromophobe RCC. RCC occurs often due to loss von Hippel‑Lindau (VHL) accumulation lipids glycogen, cells may exhibit sensitivity the disruption normal metabolism or homologous recombination gene defect. Although application molecular‑targeted drugs (tyrosine kinase inhibitors) immune checkpoint inhibitors has been recommended for treatment advanced RCC, more targets DNA damage repair (DDR) signaling pathway...

Abstract Background Competitive endogenous RNAs (ceRNAs) have revealed a new mechanism of interaction between RNAs. However, an understanding the ceRNA regulatory network in Wilms tumour (WT) remains limited. Methods The expression profiles mRNAs, miRNAs and lncRNAs samples normal were obtained from Therapeutically Applicable Research to Generate Effective Treatment (TARGET) database. EdgeR package was employed identify differentially expressed lncRNAs, mRNAs. Functional enrichment analyses...

Background: Evidence increasingly indicates that HPV infection plays a pivotal role in the initiation and progression of bladder cancer (BC). Yet, determining predictive value HPV-associated genes BC remains challenging. Methods: We identified differentially expressed patients from TCGA GEO databases. screened prognostic using COX LASSO regression, subsequently establishing risk prediction model. The model's precision clinical relevance were gauged Kaplan-Meier survival analyses ROC curves....

Globally, real-time reverse transcription-polymerase chain reaction (rRT-PCR) is the reference detection technique for SARS-CoV-2, which expensive, time consuming, and requires trained laboratory personnel. Thus, a cost-effective, rapid antigen test urgently needed. This study evaluated performance of tests (RATs) SARS-CoV-2 compared with rRT-PCR, considering different influencing factors.We enrolled total 214 symptomatic individuals known COVID-19 status using rRT-PCR. We collected tested...

Abstract Bladder cancer (BLCA) is a common and difficult‐to‐manage disease worldwide. Most type of BLCA urothelial carcinoma (UC). Fibrillin 2 (FBN2) was first discovered while studying Marfan syndrome, its encoded products are associated with elastin fibres. To date, the role FBN2 in remains unclear. The authors downloaded data from Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO). patients were divided into high expression low groups, survival curve, clinical characteristics,...

Renal transplantation can significantly improve the survival rate and quality of life patients with end-stage renal disease, but probability acute rejection (AR) in adult transplant recipients is still approximately 12.2%. Machine learning (ML) superior to traditional statistical methods various clinical scenarios. However, current AR model constructed only through simple difference analysis or a single queue, which cannot guarantee accuracy prediction. Therefore, this study identified...

Background: As an epigenetic alteration, DNA methylation plays important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis classification of tumor heterogeneity. Methods: Methylation data, RNA-sequencing (RNA-seq) corresponding clinical information were downloaded from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. The prognostic values subtypes identified. Results: Four patients identified by consensus cluster...

This paper extends a text classification method utilizing natural language processing (NLP) into the field of traditional Chinese medicine (TCM) compound decoction to effectively and scientifically extend TCM duration. Specifically, duration named TCM-TextCNN is proposed fuse multi-dimensional herb features improve TextCNN. Indeed, first, we utilize word vector technology construct feature vectors names medicinal parts, aiming describe characteristics comprehensively. Second, considering...

Background Kidney stone disease (KSD) is a widespread problem in urology. But the associations between Geriatric Nutritional Risk Index (GNRI), an important indicator for assessing nutritional status of elderly hospitalized patients, and KSD are understudied. Objective Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2007–2018, our study analyzed correlation GNRI prevalence at cross-sectional level. The aim was to explore association identify potential risk...

This research seeks to assess the connection between healthy sleep patterns and occurrence of kidney stone disease (KSD) by analyzing data obtained from a large-scale cohort study. We examined 313,870 initial participants without KSD UK Biobank. Five factors were assessed: no frequent excessive daytime sleepiness, early chronotype, snoring, sleeping 7-8 h daily, never or rarely experiencing insomnia at baseline. A score 0 5 was assigned according these criteria. utilized Cox proportional...

In this study, we aimed to identify transplantation tolerance (TOL)-related gene signature and use it predict the different types of renal allograft rejection performances in kidney transplantation. Gene expression data were obtained from Expression Omnibus (GEO) database, differently expressed genes (DEGs) performed, ontology (GO) function enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis also conducted. The machine learning methods combined analyze feature TOL-related...

As the main histological subtype of renal cell carcinoma, clear carcinoma (ccRCC) places a heavy burden on health worldwide. Autophagy-related long non-coding RNAs (ARlncRs) have shown tremendous potential as prognostic signatures in several studies, but relationship between them and ccRCC still has to be demonstrated.The RNA-sequencing clinical characteristics 483 patients were downloaded download from Cancer Genome Atlas International Consortium. ARlncRs determined by Pearson correlation...

In view of the limitations classifying body constitutional type in traditional Chinese medicine (BCTTCM) with method, probability neural networks (PNN) method was put forward. The characteristic parameters BCTTCM were obtained median, and a PNN model designed for classification. trained tested using 30 samples, it yields good classification accuracies BCTTCM. overall accuracy network 95% training set. It 80% validation indicated that effective based on is feasible.

Abstract Background Bladder cancer (BC) is one of the most common malignant urinary system in worldwide. The purpose present study was to analysis differentially expressed genes (DEGs), biological pathways and prognostic significance BC by bioinformatics analysis. Methods gene expression dataset GSE7476 mRNA Seq sequencing data were downloaded respectively from GEO TCGA. A total 220 DEGs obtained BC. GO KEGG pathway performed for up- down-regulated DEGs. Then, a protein-protein interaction...

Hough transform has the advantage of incomplete edge recognition. A large number practices show that: for actual circular object detection, detected points are usually concentrated in a relatively continuous arc. If scattered various positions circle, it is interference noise that causes wrong recognition target. On this basis, paper proposes an algorithm, is, to calculate standard deviation angle points, and compare value with so as judge whether correct. In paper, algorithm applied human...

As an inevitable event after kidney transplantation, ischemia‒reperfusion injury (IRI) can lead to a decrease in transplant success. The search for signature genes of renal (RIRI) is helpful improving the diagnosis and guiding clinical treatment.We first downloaded 3 datasets from GEO database. Then, differentially expressed (DEGs) were identified applied functional enrichment analysis. After that, we performed three machine learning methods, including random forest (RF), Lasso regression...