A5033663777- Immune Cell Function and Interaction
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Bladder and Urothelial Cancer Treatments
- Kidney Stones and Urolithiasis Treatments
- Ferroptosis and cancer prognosis
- Heat shock proteins research
- Pelvic floor disorders treatments
- Pediatric Urology and Nephrology Studies
- Renal and related cancers
- TGF-β signaling in diseases
- Inflammasome and immune disorders
- Neonatal Respiratory Health Research
- Endoplasmic Reticulum Stress and Disease
- Circular RNAs in diseases
- Cancer-related Molecular Pathways
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Covalent Organic Framework Applications
- Childhood Cancer Survivors' Quality of Life
- Urinary Bladder and Prostate Research
- Renal Transplantation Outcomes and Treatments
- Mitochondrial Function and Pathology
- Molecular Biology Techniques and Applications
Sun Yat-sen University
2023-2025
Eighth Affiliated Hospital of Sun Yat-sen University
2023-2024
Soochow University
2018-2024
Dalian University
2023
Dalian University of Technology
2023
Third Affiliated Hospital of Guangzhou Medical University
2021-2022
Guangzhou Medical University
2021-2022
Previous studies have reported an inconsistent relationship between overactive bladder (OAB) and the consumption of tea, coffee, caffeine. Our study aims to determine these associations in a large nationally representative adult sample.
This study investigates the association between exposure to environmental pollutants—perchlorate, nitrate, and thiocyanate (PNT)—and prevalence of kidney stone disease (KSD) in US adults, utilizing data from National Health Nutrition Examination Survey (NHANES) 2007–2018. With increasing incidence KSD, understanding risk factors has become crucial. While PNT compounds are known be associated with various health issues, their role KSD remains unclear. A cross-sectional analysis 11,350...
Bladder cancer (BC) is the most common malignancy in urinary system and prone to recurrence metastasis. Pyroptosis a kind of cell necrosis that triggered by gasdermin protein family. lncRNAs are noncoding RNAs more than 200 nucleotides long. Both pyroptosis associated with tumor development progression. This study aimed at exploring establishing prognostic signature BC based on pyroptosis-related lncRNAs. In this study, The Cancer Genome Atlas (TCGA) database provided us RNA sequencing...
Background: Evidence increasingly indicates that HPV infection plays a pivotal role in the initiation and progression of bladder cancer (BC). Yet, determining predictive value HPV-associated genes BC remains challenging. Methods: We identified differentially expressed patients from TCGA GEO databases. screened prognostic using COX LASSO regression, subsequently establishing risk prediction model. The model's precision clinical relevance were gauged Kaplan-Meier survival analyses ROC curves....
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage major causes RISI. Nuclear factor erythroid 2-related 2 (Nrf2) considered as a key mediator cellular antioxidant response. However, whether Nrf2 can alleviate RISI high-dose irradiation remains unknown. In this study, we demonstrated that Nrf2-deficient ( -/- ) mice were susceptible to...
Background: As an epigenetic alteration, DNA methylation plays important role in early Wilms tumorigenesis and is possibly used as marker to improve the diagnosis classification of tumor heterogeneity. Methods: Methylation data, RNA-sequencing (RNA-seq) corresponding clinical information were downloaded from Therapeutically Applicable Research Generate Effective Treatments (TARGET) database. The prognostic values subtypes identified. Results: Four patients identified by consensus cluster...
Radiation-induced liver damage (RILD) has become a limitation in radiotherapy for hepatocellular carcinoma. We established rabbit model of RILD by CyberKnife. Electron microscopy analysis revealed obvious nuclear atrophy and disposition fat the nucleus after irradiation. then utilized mass spectrometry-based label-free relative quantitative proteomics approach to compare global proteomic changes response radiation. In total, 2365 proteins were identified, including 338 that significantly...
Wilms tumor (WT) is a common pediatric renal cancer, with poor prognosis and high-risk recurrence in some patients. The inflammatory microenvironment gradually gaining attention WT. In this study, novel inflammation-related signatures prognostic model were explored integrated using bioinformatics analysis. mRNA profile of patients WT genes (IRGs) acquired from Therapeutically Available Research to Generate Effective Treatments (TARGET) Gene Set Enrichment Analysis (GSEA) databases,...
Background Kidney stone disease (KSD) is a widespread problem in urology. But the associations between Geriatric Nutritional Risk Index (GNRI), an important indicator for assessing nutritional status of elderly hospitalized patients, and KSD are understudied. Objective Utilizing data from National Health Nutrition Examination Survey (NHANES) spanning 2007–2018, our study analyzed correlation GNRI prevalence at cross-sectional level. The aim was to explore association identify potential risk...
In this study, we aimed to identify transplantation tolerance (TOL)-related gene signature and use it predict the different types of renal allograft rejection performances in kidney transplantation. Gene expression data were obtained from Expression Omnibus (GEO) database, differently expressed genes (DEGs) performed, ontology (GO) function enrichment Kyoto Encyclopedia Genes Genomes (KEGG) pathway analysis also conducted. The machine learning methods combined analyze feature TOL-related...
As the main histological subtype of renal cell carcinoma, clear carcinoma (ccRCC) places a heavy burden on health worldwide. Autophagy-related long non-coding RNAs (ARlncRs) have shown tremendous potential as prognostic signatures in several studies, but relationship between them and ccRCC still has to be demonstrated.The RNA-sequencing clinical characteristics 483 patients were downloaded download from Cancer Genome Atlas International Consortium. ARlncRs determined by Pearson correlation...
Targeted ferroptosis is a reliable therapy to inhibit tumor growth and enhance immunotherapy. This study generated novel prognostic risk signature based on ferroptosis-related genes (FRGs), explored the ability in clinic for clear cell renal carcinoma (ccRCC).The expression profile of mRNA FRGs ccRCC patients were exacted from The Cancer Genome Atlas (TCGA) database. A was constructed univariable multivariable Cox-regression analysis. Kaplan-Meier (KM) survival curves receiver operating...
Abstract Background Inflammation and long noncoding RNAs (lncRNAs) are gradually becoming important in the development of bladder cancer (BC). Nevertheless, potential inflammatory response-related lncRNAs (IRRlncRNAs) as a prognostic signature remains unexplored BC. Methods The Cancer Genome Atlas (TCGA) provided RNA expression profiles clinical information BC samples, GSEA Molecular Signatures database 1171 inflammation-related genes. IRRlncRNAs were identified using Pearson correlation...