A5101444412- Reconstructive Surgery and Microvascular Techniques
- Effects of Radiation Exposure
- Mesenchymal stem cell research
- Wound Healing and Treatments
- Reconstructive Facial Surgery Techniques
- NF-κB Signaling Pathways
- Tissue Engineering and Regenerative Medicine
- Periodontal Regeneration and Treatments
- Skin Protection and Aging
- Cleft Lip and Palate Research
- interferon and immune responses
- Head and Neck Surgical Oncology
- Nasal Surgery and Airway Studies
- Circadian rhythm and melatonin
- Inflammasome and immune disorders
- Heat shock proteins research
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Medical Imaging and Analysis
- Dermatologic Treatments and Research
- Medical and Biological Ozone Research
- Shoulder and Clavicle Injuries
- Trauma Management and Diagnosis
- Diabetic Foot Ulcer Assessment and Management
- Angiogenesis and VEGF in Cancer
Soochow University
2012-2025
Second Affiliated Hospital of Soochow University
2012-2025
Chengdu Medical College
2019-2025
China National Nuclear Corporation
2021-2024
Jiangnan University
2024
Wuxi Fourth People's Hospital
2024
West China Medical Center of Sichuan University
2021-2024
University of Benin
2018
University of Hong Kong
1982
Ultraviolet (UV) radiation is ubiquitous in the environment, which has been classified as an established human carcinogen. As largest and outermost organ of body, direct exposure skin to sunlight or UV can result sunburn, inflammation, photo-immunosuppression, photoaging even cancers. To date, there are tactics protect by preventing reducing amount skin. Nevertheless, deciphering essential regulatory mechanisms may pave way for therapeutic interventions against UV-induced disorders....
Ionizing radiation has been widely used in industry, medicine, military and agriculture. Radiation-induced skin injury is a significant concern the context of radiotherapy accidental exposure to radiation. The molecular changes at single-cell level intercellular communications during radiation-induced are not well understood.
Twenty-three patients with primary spontaneous pneumothorax and 30 secondary treated by intercostal catheter drainage underwater seal were divided randomly into two groups, one receiving suction (up to 20 cm H2O pressure) the other no suction. The success rate was 57% for former 50% latter. group spent an average of five days in hospital, whereas non-suction averaged four days. Suction therefore did not have any advantage. To determine how soon could be removed without complication, also...
Abstract The dome-shaped cornea is a transparent, non-vascularized, and epithelialized highly organized tissue. Physical chemical injuries may trigger corneal wound healing (CWH) response result in neovascularization that impairs the visual function. CWH involves not only migration, proliferation, differentiation of cells different layers cornea, but also mobilization immune cells. We demonstrated here human adipose-derived mesenchymal stromal (ADSCs) could effectively inhibit during...
Nuclear technology has been extensively used in various fields, increasing the possibility of radiation exposure to humans. Radiation outcomes may be classified as whole‑body irradiation or local irradiation. Clinically, refers a relatively limited portion body, with injury confined directly exposed tissues. However, locally irradiated tissues can trigger systemic reactions through release inflammatory factors damage blood cells at site. The circulating population peripheral mononuclear...
Radiation-induced skin fibrosis is a detrimental and chronic disorder that occurs after radiation exposure. The molecular changes underlying the pathogenesis of radiation-induced human have not been extensively reported. Technical advances in proteomics enabled exploration biomarkers fibrosis, with potential to broaden our understanding this disease. In study, we compared protein expression fibrotic adjacent normal tissues using iTRAQ-based technology. We identified 186 preferentially...
The origin of rhabdomyosarcoma (RMS) remains controversial. However, specific microRNAs (miRNAs) are downregulated in RMS and it is possible that re-expression these miRNAs may lead to differentiation. Transforming growth factor-β1 (TGF-β1) known block differentiation RMS. We therefore analyzed miRNA microarrays cell lines with or without TGF-β1 knockdown identified a novel anti-oncogene miR-411-5p. Re-expression miR-411-5p inhibited proliferation vitro tumorigenicity vivo. Using luciferase...
Abstract The extensive application of nuclear technology has increased the potential uncontrolled radiation exposure to public. Since skin is largest organ, radiation‐induced injury remains a serious medical concern. Organisms evolutionally develop distinct strategies protect against environment insults and related research may bring novel insights into therapeutics development. Here, 26 peptides are identified in tissues frogs ( Pelophylax nigromaculatus ) exposed electron beams, among...
Purpose: To evaluate the anticancer activity of myricetin against skin cancer A431 cell lines.Methods: Cell viability was determined by MTT and colony formation assays. Apoptosis DAPI annexin V/PI staining. cycle, ROS MMP analysis were performed flow cytometry. migration invasion assessed Boyden Chamber assay, while protein expression using western blotting.Results: Myricetin showed considerable lines. However, lower cytotoxic effects observed in normal FR2 cells. The due to ROS-prompted...
Radiation-induced skin injury, which remains a serious concern in radiation therapy, is currently believed to be the result of vascular endothelial cell injury and apoptosis. Here, we established model acute radiation-induced compared effect different growth factors on healing by observing changes microcirculation Vascular factor (VEGF) was more effective at inhibiting apoptosis preventing progression than other factors. A new strategy for improving bioavailability developed loading VEGF...
Radiogenic skin injury (RSI) is a common complication during cancer radiotherapy or accidental exposure to radiation. The aim of this study investigate the metabolism bile acids (BAs) and their derivatives RSI.
Radiation-induced acute skin injury and consequent fibrosis are common complications of cancer radiotherapy radiation accidents. Stromal cell-derived factor-1α (SDF-1α) its receptor, CXC chemokine receptor 4 (CXCR4) have been shown to be involved in multiple cellular events. However, the role SDF-1α/CXCR4 axis radiation-induced has not reported. In this study, we found that expression SDF-1α CXCR4 was significantly increased irradiated tissues humans, monkeys rats, compared their...
Severe radiation-induced skin injury is a complication of tumor radiotherapy and nuclear accidents. Cell therapy potential treatment for injury. The stromal vascular fraction (SVF) newer material in stem cell that made up cells harvested from adipose tissue, which has been shown to promote the healing refractory wounds different causes. In this study, SVF was isolated patients with Adipose-derived (ADSCs) accounted approximately 10% by flow cytometry. Compared control group rats,...
B7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory effects in adaptive anti-tumour immunity. up-regulated many malignant tumours, including breast cancer. Therefore, we hypothesise B7-H3, which an immunosuppressive role, suppresses The aim of this study was to clarify the role tumor microenvironment cancer, explore possibility as target for clinical immunotherapy, provide reference work. We knocked down with siRNA MCF7 cancer cells, termed...
Abstract Overexposure to ultraviolet light (UV) has become a major dermatological problem since the intensity of radiation is increasing. As an adaption outside environments, amphibians gained excellent peptide‐based defense system in their naked skin from secular evolution. Here, we first determined adaptation and resistance dark‐spotted frogs (Pelophylax nigromaculatus ) constant B (UVB) exposure. Subsequently, peptidomics frog identified series novel peptides response UVB. These...
The present study determined the expression of microRNA (miR)‑663 in hypertrophic scar (HS) tissues and investigate regulatory mechanisms miR‑663 HS. A total 51 patients diagnosed with HS between December 2013 February 2016 were included study. (experimental group) HS‑adjacent (control collected. Primary fibroblasts obtained from tissue transfected small‑interfering RNA against transforming growth factor (TGF)‑β1 or mimics. Reverse‑transcription quantitative PCR was used to determine levels...
Here we report on the interventions taken to treat a patient exposed high-dose radiation and provide protocol for treating such patients in future. The patient, Mr. Wang, was 58-year-old male janitor who accidentally 192Ir source with an activity of 966.4 GBq or 26.1 Ci. dose estimated lower right limb 4,100 Gy, whereas whole-body effective 1.51 Gy. diagnosis made according results estimation clinical manifestations. Systemic treatment included stimulating bone marrow hematopoietic cells,...