A5077781207- Cancer Immunotherapy and Biomarkers
- Renal cell carcinoma treatment
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
Air Force Medical University
2021
Xijing Hospital
2021
Soochow University
2021
Second Affiliated Hospital of Soochow University
2021
The tumor microenvironment (TME) plays an important role in the progression of renal cell carcinoma (RCC). Cancer-associated fibroblasts (CAFs) are considered to constitute a major component TME and participate various tumor-promoting molecular events. We have previously confirmed that CD248 represents promising biomarker CAFs, which may provide insight into CAF-based effects. However, CAF-mediated potential mechanism remain largely unknown RCC patients.Expression profiling clinical data...
B7-H3 is a type I membrane protein that has contradictory co-stimulatory and co-inhibitory effects in adaptive anti-tumour immunity. up-regulated many malignant tumours, including breast cancer. Therefore, we hypothesise B7-H3, which an immunosuppressive role, suppresses The aim of this study was to clarify the role tumor microenvironment cancer, explore possibility as target for clinical immunotherapy, provide reference work. We knocked down with siRNA MCF7 cancer cells, termed...