A5101436928- Mesenchymal stem cell research
- Nerve injury and regeneration
- Alzheimer's disease research and treatments
- Virus-based gene therapy research
- Cardiac electrophysiology and arrhythmias
- Liver physiology and pathology
- Receptor Mechanisms and Signaling
- Gut microbiota and health
- Neuroinflammation and Neurodegeneration Mechanisms
- Flavonoids in Medical Research
- Immunotherapy and Immune Responses
- Ion channel regulation and function
- CAR-T cell therapy research
- Neurogenesis and neuroplasticity mechanisms
- Ectopic Pregnancy Diagnosis and Management
- Viral-associated cancers and disorders
- Atherosclerosis and Cardiovascular Diseases
- Natural Compounds in Disease Treatment
- Maternal and fetal healthcare
- Histone Deacetylase Inhibitors Research
- Hereditary Neurological Disorders
- Beetle Biology and Toxicology Studies
- Spinal Cord Injury Research
- Cancer Mechanisms and Therapy
- Neurological Disease Mechanisms and Treatments
Guiyang Medical University
2018-2025
Affiliated Hospital of Guizhou Medical University
2018-2024
Zhejiang A & F University
2019-2024
Soochow University
2016-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2023
First Affiliated Hospital of Zhengzhou University
2019
Soochow University
2019
Suzhou Research Institute
2019
Zhongshan Hospital
2015
Fudan University
2015
To characterize the intestinal flora of patients with epilepsy and its correlation epilepsy.Patients ages > 18 years were consecutively enrolled from outpatient department, Affiliated Hospital Guizhou Medical University January 2018 to December 2019. A total 71 subjects recruited, including (n = 41) as an observation group patient family members 30) a control group. Fresh stool specimens all collected. The 16S ribosomal RNA sequencing was analyzed determine changes in composition epilepsy....
Exploring effective, prompt and universally applicable approaches for inducing the differentiation of glioblastoma (GBM) into terminally differentiated cells, such as astrocytes or neurons that cease cell division, is pivotal success GBM therapy. In this study, a neuronal-specific promoter-reporter system was employed to screen small molecules promote neural differentiation. The cocktail YFSS, consisting Y27632, Forskolin, SB431542 SP600125, which selectively targets ROCK, cAMP, TGF-β JNK...
As aging progresses, the structures and functions of immune organs such as thymus spleen deteriorate, leading to impaired function senescence. This study investigated potential umbilical cord mesenchymal stem cells (UC-MSCs) mitigate D-galactose-induced senescence by enhancing structural functional integrity regulating gut microbiota. The findings show that UC-MSCs treatment significantly delayed atrophy reduced number senescence-associated β-galactosidase (SA-β-gal) positive cells. At...
Neural scaffolds consisting of dermal fibroblast-reprogrammed neurons and 3D silk fibrous materials promote repair spinal cord injury.
In this study, we investigated how human umbilical cord mesenchymal stem cells exerted a neuroprotective effect via antiapoptotic mechanisms in neonatal hypoxic-ischemic encephalopathy rat model. A total of 78 10-day old (P10) rats were used. After collected from cords and amplified culture, they administered to subjects 1 h after induced treatment. The short-term (48 h) long-term (28 day) outcomes evaluated treatment using neurobehavioral function assessment. Triphenyltetrazolium chloride...
Mesenchymal stem cells (MSCs) can be used to treat many diseases, including spinal cord injury (SCI). Treatment relies mostly on the precise navigation of site for rebuilding damaged cord. However, key factors guiding MSCs epicenter SCI remain unknown. Here, we demonstrated that calcitonin gene-related peptide (CGRP), a neural synthesized in cord, dramatically aid homing human umbilical mesenchymal (HUMSCs) cord-transected rats. First, HUMSCs exhibited chemotactic responses vitro CGRP. By...
To compare the safety and efficacy of prophylactic balloon occlusion abdominal aorta (PBOA) performed at level renal artery (PBOA-ARA) or below this (PBOA-BRA) for management placenta accreta.We conducted a retrospective investigation 57 women scheduled cesarean delivery who underwent PBOA our hospital between October 2015 July 2017. The was (PBOA-ARA group; n = 30) (PBOA-BRA 27) origin. perioperative data two groups were compared.Estimated blood loss lower in PBOA-ARA group than PBOA-BRA (p...
Interleukin-24 (IL-24) is a promising agent for cancer immunotherapy that induces apoptosis of tumor cells and enhances T cell activation function. In order to improve the antitumor activity induced by Newcastle disease virus (NDV)-modified vaccine, we generated recombinant NDV expressing IL-24 using reverse genetics. Irradiated infected with LX/IL-24 showed stable expression. The cytotoxicity assay LX/IL-24-infected murine melanoma significantly enhanced immune response in vitro. Then,...
Tripterygium wilfordii Hook F. (TWHF) is a Chinese traditional medicine with cardiac toxicities. However, the mechanism of acute toxicity not very clear. By using patch clamp techniques, we found that 0.05 mg/ml and 0.1 aqueous crude extract TWHF inhibit 21.4 ± 1.6% 86.7 5.7% (n = 5) hERG current Amplitudes (IhERG) respectively. We further Celastrol, one main components TWHF, inhibits an IC50 0.83 μM. Additional mutagenesis studies show mutations T623A, S624A F656A significantly alter...
Mesenchymal stem cells (MSCs) have shown great potential for the treatment of liver injuries, and therapeutic efficacy greatly depends on their homing to site injury. In present study, we detected significant upregulation hepatocyte growth factor (HGF) in serum mice with acute or chronic vitro study revealed that miR-9-5p miR-221-3p promoted migration human MSCs (hMSCs) toward HGF. Moreover, overexpression hMSC injured resulted significantly higher engraftment upon peripheral infusion. hMSCs...
Abstract Alzheimer’s disease is characterized by abnormal β-amyloid (Aβ) plaque accumulation, tau hyperphosphorylation, reactive oxidative stress, mitochondrial dysfunction and synaptic loss. Myricetin, a dietary flavonoid, has been shown to have neuroprotective effects in vitro vivo. Here, we aimed elucidate the mechanism pathways involved myricetin’s protective effect on toxicity induced Aβ42 oligomer. Neuronal SH-SY5Y cells were pretreated with myricetin before incubation The levels of...
The human ether-a-go-go-related gene (hERG) inhibition is a serious cardiac safety issue. Although the of hERG by majority compounds are stable, strength few compounds, including Erythromycin, remarkably rising from room temperature (RT) to physiological (PT). Understanding features erythromycin against could help us decide which needed for further study. whole cell patch clamp technique was used investigate effects on channels in different temperatures. We found that caused concentration...
Background Alzheimer’s disease (AD) is a neurodegenerative disorder marked by cognitive decline and memory loss. Recent research underscores the crucial role of astrocytes in AD. This study reviews trends contributions on AD from 2000 to 2024, shedding light evolving landscape. Methods We conducted bibliometric analysis using data Web Science Core Collection, covering publications January 1, 2000, July 6, “Alzheimer’s disease” “astrocytes.” identified 5,252 relevant English articles reviews....
To evaluate the clinical effects of autologous cytokine-induced killer cell(CIK) on cumulative survival and reactivation rate hepatitics B virus(HBV) after radiofrequency ablation(RFA) combined with transcatheter arterial chemoembolization(TACE).A total 156 patients hepatocellular carcinoma treated from June 2006 to September 2012 in Shengli Oilfield Central Hosptial were divided into control group(RFA, TACE) research TACE, CIK). According tumors number, diameter vascular invasion condition,...