A5010747851- MicroRNA in disease regulation
- Sarcoma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Neurogenesis and neuroplasticity mechanisms
- Plant and animal studies
- Glioma Diagnosis and Treatment
- Insect and Arachnid Ecology and Behavior
- Axon Guidance and Neuronal Signaling
- Neurobiology and Insect Physiology Research
Fudan University
2024-2025
Zhongshan Hospital
2024-2025
State Key Laboratory of Medical Neurobiology
2025
Second Affiliated Hospital of Soochow University
2024
Soochow University
2013-2024
During cortical development, radial glial cells (neural stem cells) initially are neurogenic, generating intermediate progenitor that exclusively produce glutamatergic pyramidal neurons. Next, generate tripotential (Tri-IPCs) give rise to astrocytes and oligodendrocytes, olfactory bulb interneurons. The molecular mechanisms underlying the transition from neurogenesis gliogenesis, subsequent fate determination of astrocytes, interneurons, remain unclear. Here, we report extracellular...
The molecular basis for cortical expansion during evolution remains largely unknown. Here, we report that fibroblast growth factor (FGF)-extracellular signal-regulated kinase (ERK) signaling promotes the self-renewal and of radial glial (RG) cells. Furthermore, FGF-ERK induces bone morphogenic protein 7 ( Bmp7 ) expression in RG cells, which increases length neurogenic period. We demonstrate ERK Sonic Hedgehog (SHH) mutually inhibit each other provide evidence is elevated cells development...
The origin of rhabdomyosarcoma (RMS) remains controversial. However, specific microRNAs (miRNAs) are downregulated in RMS and it is possible that re-expression these miRNAs may lead to differentiation. Transforming growth factor-β1 (TGF-β1) known block differentiation RMS. We therefore analyzed miRNA microarrays cell lines with or without TGF-β1 knockdown identified a novel anti-oncogene miR-411-5p. Re-expression miR-411-5p inhibited proliferation vitro tumorigenicity vivo. Using luciferase...
Parkinson's disease (PD) is a complex neurodegenerative disorder, characterized by the aggregation of α-synuclein (α-syn). Current research increasingly indicates prevalence sleep-wake disorders in early-stage PD, although underlying pathogenic mechanisms remain unclear. In this study, transgenic Drosophila models were utilized to observe excessive daytime sleepiness and impaired anticipation flies overexpressing α-syn pan-neurons circadian clock neurons. Additionally, deficits projection...