A5103118535- Metabolism, Diabetes, and Cancer
- Mitochondrial Function and Pathology
- Genomics, phytochemicals, and oxidative stress
- Tea Polyphenols and Effects
- DNA Repair Mechanisms
- Spinal Fractures and Fixation Techniques
- Cancer-related molecular mechanisms research
- Prenatal Screening and Diagnostics
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Spine and Intervertebral Disc Pathology
- IL-33, ST2, and ILC Pathways
- Protein Kinase Regulation and GTPase Signaling
- Peroxisome Proliferator-Activated Receptors
- TGF-β signaling in diseases
- Tannin, Tannase and Anticancer Activities
- Receptor Mechanisms and Signaling
- Redox biology and oxidative stress
- Cell death mechanisms and regulation
- Breast Lesions and Carcinomas
- Pancreatic and Hepatic Oncology Research
- Global Cancer Incidence and Screening
- Circular RNAs in diseases
- Colorectal Cancer Treatments and Studies
- ATP Synthase and ATPases Research
Second Affiliated Hospital of Soochow University
2019-2024
Soochow University
2014-2024
Thomas Jefferson University
2024
Sichuan Agricultural University
2024
Qilu Hospital of Shandong University
2019
307th Hospital of Chinese People’s Liberation Army
2015
Zhejiang University
2012
Chinese women tend to have small and dense breasts ultrasound is a common method for breast cancer screening in China. However, its efficacy cost comparing with mammography has not been evaluated randomised trials.At 14 centres across China during 2008-2010, 13 339 high-risk aged 30-65 years were be screened by alone, or both methods at enrollment 1-year follow-up.A total of 12 519 8692 underwent the initial second screenings, respectively. Among 30 cancers (of which 15 stage 0/I) detected,...
Non-small cell lung cancer (NSCLC) is the most common type of cancer. (-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, widely studied as chemopreventive agent with potential anti-cancer effects. The NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway considered to mediate cellular resistance EGCG. Metformin, classical antidiabetic drug, has been shown prevent progression. Researchers have not reported whether metformin potentiates efficacy In this...
Radiation-induced skin injury is a common side effect of radiotherapy and can limit the duration dose radiotherapy. Most early work focused on elimination reactive oxygen species (ROS) after radiation; however, less known about mechanisms underlying amplification ROS consequent by radiation. 5,6,7,8-Tetrahydrobiopterin (BH4) an essential cofactor for all nitric oxide synthases. Inadequate availability BH4 leads to uncoupling synthases production highly oxidative radicals. In this study, we...
To investigate clinical features and ultrasound findings in cases of placental site trophoblastic tumor (PSTT).Fourteen PSTT treated at our institution between May 2004 October 2010 were identified the on transvaginal sonography (TVS) investigated. Pathological confirmation was obtained all cases.The most frequent symptoms associated with abnormal vaginal bleeding, which present 11 cases, amenorrhea, five cases. The interval from antecedent pregnancy to diagnosis 4-36 (median, 12.5) months....
Osteoporosis-related bone fracture and falls have a severe impact on patients' daily lives. Osteoblasts are bone-building cells that play vital role in formation remodeling. Imbalanced osteoblast differentiation could lead to osteoporosis. GPR39 is an orphan G protein-coupled receptor mediates metabolic pathways. In this study, we show expressed MC3T3-E1 cells. Osteoblast culture media induces GPR39, suggesting differentiation-responsive factor. Activation of using its selective agonist TC-G...
The purpose of this study was to investigate the effect human antigen R (HuR) downregulation and potential target genes HuR on progression esophageal squamous cell carcinoma (ESCC).In study, a proteomics assay used detect expression proteins after downregulation, luciferase presence binding site 3'-untranslated region (3'-UTR) interleukin 18 (IL-18). In addition, colony formation assay, MTT, EdU incorporation Western blot, flow cytometry, immunohistochemistry, transwell invasion wound...
Radiation-induced skin injury (RISI) commonly occur in cancer patients who received radiotherapy and is one of the first clinical symptoms after suffering from nuclear exposure. Oxidative damage major causes RISI. Nuclear factor erythroid 2-related 2 (Nrf2) considered as a key mediator cellular antioxidant response. However, whether Nrf2 can alleviate RISI high-dose irradiation remains unknown. In this study, we demonstrated that Nrf2-deficient ( -/- ) mice were susceptible to...
In recent years, large language models (LLMs) have been widely adopted in political science tasks such as election prediction, sentiment analysis, policy impact assessment, and misinformation detection. Meanwhile, the need to systematically understand how LLMs can further revolutionize field also becomes urgent. this work, we--a multidisciplinary team of researchers spanning computer science--present first principled framework termed Political-LLM advance comprehensive understanding...
Objective To elucidate the mechanism of radiation resistant effect LyGDI on NSCLC A549 cells.Methods and H460 cells were irradiated with X-rays 0,2,4 6 Gy.The clone-forming assay was used to detect cell survival radiosensitivity.The expressions COX-2 (Cyclooxygenase-2),a key radiosensitivity-related protein,were detected using Western blot.The miR-34 families analyzed RT-PCR.50 nmol/L mature miR-34c transfected into cells.Results The expression levels much higher in radioresistive than that...
3560 Background: MMR has been suggested, with controversy, as prognostic and predictive marker of adjuvant chemotherapy (aCT) in stage II colon cancer. The aim this study was to evaluate association between survival Methods: Between January 2003 December 2008, 860 patients (pts) curatively resected cancer were included. Deficient (dMMR) defined tumors MLH1 and/or MSH2 loss others proficient (pMMR) by immunohistochemistry. Clinical risk (CR) factors used for dividing pts into high or standard...