A5078900483- Allergic Rhinitis and Sensitization
- Food Allergy and Anaphylaxis Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Asthma and respiratory diseases
- Contact Dermatitis and Allergies
- Dermatology and Skin Diseases
- Mast cells and histamine
- Urticaria and Related Conditions
- Drug-Induced Adverse Reactions
- Autoimmune Bullous Skin Diseases
- Healthcare and Venom Research
- Peptidase Inhibition and Analysis
- Breast Cancer Treatment Studies
- Pharmacovigilance and Adverse Drug Reactions
- Cancer Risks and Factors
- Anesthesia and Pain Management
- Breast Lesions and Carcinomas
- Blood Coagulation and Thrombosis Mechanisms
- Insect and Pesticide Research
- Cancer Diagnosis and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Global Cancer Incidence and Screening
- Artificial Intelligence in Healthcare and Education
- Cancer Research and Treatments
- SARS-CoV-2 and COVID-19 Research
Ruijin Hospital
2025
Peking Union Medical College Hospital
2014-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2014-2024
Lishui Central Hospital
2024
National Clinical Research Center for Digestive Diseases
2020-2024
Institute of Hematology & Blood Diseases Hospital
2021
NewYork–Presbyterian Hospital
2013
Cornell University
2013
Penn State Milton S. Hershey Medical Center
2013
Sanquin
2013
Chinese women tend to have small and dense breasts ultrasound is a common method for breast cancer screening in China. However, its efficacy cost comparing with mammography has not been evaluated randomised trials.At 14 centres across China during 2008-2010, 13 339 high-risk aged 30-65 years were be screened by alone, or both methods at enrollment 1-year follow-up.A total of 12 519 8692 underwent the initial second screenings, respectively. Among 30 cancers (of which 15 stage 0/I) detected,...
Monoclonal antibodies (mAbs) are novel, effective therapeutics for the treatment of inadequately controlled severe asthma. Knowledge anaphylaxis risks related to different mAbs is essential their appropriate and safe administration. This study aimed evaluate associations between anaphylactic reactions by applying statistical approaches pharmacovigilance data.This was a retrospective using data from US Food Drug Administration Adverse Event Reporting System database January 2004 September...
Data on allergic reactions after the administration of coronavirus disease (COVID-19) vaccines are limited. Our aim is to analyze reports COVID-19 vaccine administration.The Vaccine Adverse Event Reporting System database was searched for reported any from December 2020 June 2021. After data mapping, demographic and clinical characteristics cases were analyzed. Potential factors associated with anaphylaxis evaluated using multivariable logistic regression models.In total, 14,611 reported....
Patients with pollinosis are often multi-sensitized to diverse pollen allergens. However, little is known about allergy types among Chinese patients. This study aimed characterize clinical manifestations of food patients different allergy.We retrospectively analyzed 402 from an outpatient department the Peking Union Medical College Hospital who had been diagnosed by experienced allergists. All included answered a questionnaire regarding seasonal and symptoms after ingestion underwent...
Hereditary angioedema (HAE), caused by C1 inhibitor deficiency, is characterized recurrent subcutaneous or submucosal swelling. Because it rare, data on clinical features, especially in Chinese patients, are not comprehensive. Our aim was to identify the characteristics of HAE a population and enhance knowledge this disease. One hundred fifty-eight symptomatic patients were studied retrospectively. Data obtained from medical records. Statistical analyses performed using statistical software...
Background: Hereditary angioedema (HAE) is still underdiagnosed or diagnosed after a serious delay. This study aimed to evaluate the diagnostic delay (DD) and misdiagnosis of HAE, explore risk factors associated with longer DD. Methods: An Internet-based survey was sent 129 patients type 1 2 HAE who presented Allergy Department, Peking Union Medical College Hospital between 1983 2017; 107 (82.9%) responded, among whom, total 96 provided complete information about medical visits. DD divided...
Hereditary angioedema (HAE) is a rare but serious condition characterized by unpredictable and recurrent attacks affecting the skin mucosa. HAE has wide-ranging impacts on health-related quality of life (HRQoL) patients. This study aims to assess HRQoL Chinese patients with using 36-item Short Form Health Survey (SF-36v2) explore potential risk factors for low HRQoL. A total 104 (47 male 57 female) over age 18 living in China known diagnosis due C1-INH deficiency completed SF-36v2 (generic...
Abstract Background Objective measures used for the differential diagnosis and severity assessment of allergic rhinitis (AR) are still lacking. The involvement hydrogen sulfide (H 2 S) in development AR indicates that nasal exhaled H S (NeH has potential as a biomarker to be patients. This study aimed evaluate application value NeH measurement AR. Methods was multi‐center cross‐sectional survey conducted Northwestern China. Demographic information collection were completed through...
There are limited real-world studies on the differences in leukotriene receptor antagonists (LTRA), H1-antihistamines (H1-AH), and inhaled corticosteroids (ICS) associated neuropsychiatric events. In this study, we aimed to analyze characteristics of drug events, compare among different categories.Disproportionality analysis Bayesian were used data mining identify suspected events with LTRA, H1-AH, ICS based United States Food Drug Administration (FDA) Adverse Event Reporting System (FAERS)...
Background: Real-world studies on the allergen specific immunotherapy (AIT), omalizumab, and dupilumab associated anaphylactic events are limited. We aimed to analyze characteristics of drug anaphylaxis, compare differences among different drugs. Methods: A disproportionality analysis Bayesian were used in data mining identify suspected anaphylaxis with AIT, based Food Drug Administration (FDA) Adverse Event Reporting System (FAERS) from January 2004 March 2021. Demographic information, time...
Clinical observation revealed that most of wheat-induced anaphylaxis (WIA)/wheat-dependent exercise-induced (WDEIA) patients showed a history recurrent urticaria. We aim to determine the association between urticaria and in wheat allergy. Population-based cohort study involved with WIA (n = 193, including WDEIA n 104), 177), non-wheat-related 584), atopic disease (excluding anaphylaxis, 221) healthy control 95) from 2009 2016. Detailed course were obtained medical records following-up...
Pollen from trees, grasses, and weeds is a common allergen source. The characteristics of pollen allergy in China are obviously different Europe. Most studies have focused on tree weed pollen, but there paucity data grass sensitisation China. Therefore, we used component-resolved diagnostics to investigate the serum-specific immunoglobulin E (sIgE) Chinese patients with pollinosis.We retrospectively analysed 547 allegy an outpatient Allergy Department Beijing, All answered questionnaires...
Hereditary angioedema (HAE) is a rare disease characterized by recurrent attacks of severe swellings the skin and submucosa. More than 900 variants SERPING1 gene associated with HAE have been identified. However, only approximately 50 identified in Chinese population. This study aimed to update mutational spectrum patients provide evidence for accurate diagnosis HAE.
Hereditary angioedema (HAE) is a rare, inherited disorder characterized by unpredictable and recurrent cutaneous mucosal oedema. This study aimed to identify the current status of HAE management in China. An internet-based survey was sent 129 patients with type 1 2 diagnosed between 1983 2017; total 107 provided complete disease information. The response rate 82.9% (107 responders). Ten reported 18 fresh frozen plasma (FFP) transfusions for main purpose treating lethal laryngeal Two adverse...
Grass pollen is an important cause of IgE-mediated allergy in countries worldwide, especially within Europe. However, there has been no research on grass northern China. We aimed to determine the status and sensitization patterns Phleum pratense (P. pratense) China.Pollen data were collected for three geographic areas (Beijing, Shenmu, Shizuishan) The study enrolled 101 patients (62 men; age range, 1-64 years; median age, 10 years) who had allergic rhinoconjunctivitis and/or asthma during...
Royal jelly and honeycomb are commonly consumed in China, anaphylaxis caused by ingestion of royal is rare. To date, there no report after China. Its cross-reactivity with still unclear.A 56-year-old Chinese female experienced two episodes within 1 hour one month. After avoiding other bee products, anaphylactic reaction occurred again. The skin prick test basophil activation showed positive reactivity to honeycomb. In immunoblotting inhibition tests, a 60 kDa protein was recognized mass...