Hyperhomocysteinemia (HHCy) is an independent and graded cardiovascular risk factor. HHCy prevalent in patients with chronic renal failure, contributing to the increased mortality rate. Controversy exists as effects of on nitric oxide (NO) production: it has been shown that both increases suppresses it. We addressed this problem by using amperometric electrochemical NO detection a porphyrinic microelectrode study responses endothelial cells incubated homocysteine (Hcy) stimulation...

In Brief OBJECTIVE: To estimate the effect of mode delivery on incidence urinary incontinence in primiparous women. METHODS: A population-based survey was mailed to all Oregon women who delivered a liveborn neonate 1-year period. Data were collected incontinence, childbirth experience, and other risk factors for at 3–6 months postpartum. Univariable analyses conducted using t tests Wilcoxon rank-sum continuous variables χ2 categorical variables. Logistic regression used odds ratios 95%...

Abstract Background Intensive care unit-acquired weakness (ICU-AW) is a prevalent and severe issue among ICU patients. Resistance training beta-hydroxy-beta-methylbutyrate (HMB) intervention have demonstrated the potential to enhance muscle function in patients with sarcopenia older adults. The purpose of this study was determine whether resistance and/or HMB administration would improve physical function, strength, quality life medical Methods In multicentre, four-arm, single-blind...

Background — It has been established that hyperhomocyst(e)inemia (HHCy) is an independent and graded risk factor for atherosclerosis, although the molecular link to atherosclerotic process remains obscure. Methods Results Screening human umbilical vein endothelial cells (HUVECs) with complementary DNA microarray gene expression modified by homocysteine (Hcy) revealed 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGCR) was upregulated. This effect confirmed using quantitative reverse...

Epithelioid inflammatory myofibroblastic sarcoma (EIMS), a specific subtype of tumors (IMT), is relatively rare malignant mesenchymal tumor with clinical features positive anaplastic lymphoma kinase (ALK), high invasiveness, treatment resistance and poor prognosis. Therefore, ALK inhibitors represent effective drugs for patients this type tumor. However, acquired remains inevitable without clear mechanism action therapeutic strategy to counteract this. Herein, chromosomal ALK-G1269A mutation...

Combined detection of antinuclear antibody (ANA), anti-double-stranded DNA (ds-DNA) and complements C3 C4 in the diagnosis systemic lupus erythematosus (SLE) was analyzed. One hundred ninety-four patients with SLE admitted to Yantaishan Hospital Yantai from January 2012 December 2017 were selected as group. A total 106 non-SLE rheumatic disease control group 120 healthy subjects The ANA anti-ds-DNA antibodies detected by ELISA complement rate nephelometry. sensitivity specificity these four...

Abstract This study was to evaluate the impact of symptoms overactive bladder (OAB) syndrome on female sexual function. Seventy nine patients with OAB (OAB group) and 79 healthy women (control underwent physical examination at our center, had their function evaluated using index (FSFI). In accordance presence or absence urge incontinence, group further divided into wet dry groups. The again after 3 months pharmacotherapy. We investigate difference between control group. effect severity...

The disruption of chondrocyte proliferation and differentiation is a critical event during the process joint injury in osteoarthritis (OA). P-15 peptides could bind to integrin receptors on various precursor cells, promote cell adhesion, release growth factors, osteoblast cells. However, role OA, particularly proliferation, not fully understood.The activity SFPQ RUNX2 bone tissue patients with was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR). Interleukin-1β...

Clinical observation revealed that most of wheat-induced anaphylaxis (WIA)/wheat-dependent exercise-induced (WDEIA) patients showed a history recurrent urticaria. We aim to determine the association between urticaria and in wheat allergy. Population-based cohort study involved with WIA (n = 193, including WDEIA n 104), 177), non-wheat-related 584), atopic disease (excluding anaphylaxis, 221) healthy control 95) from 2009 2016. Detailed course were obtained medical records following-up...

Wheat-dependent, exercise-induced anaphylaxis (WDEIA) is an allergic reaction induced by intense exercise combined with wheat ingestion. The gold standard for diagnosis of WDEIA a food challenge; however, this test unacceptable Chinese patients and unable to be approved the Ethics Committee hospitals due substantial risk. There are no diagnostic criteria patients. aim present study was propose new practical patients.We prospectively included 283 clinically diagnosed from January 1, 2010 June...

Objectives The aim of this article was to compare the differences between Intergrowth-21st (IG-21) and Fenton growth standards in classification intrauterine extrauterine restriction (EUGR) eastern Chinese preterm infants, detect which one can better relate neonatal diseases predict physical outcomes at 3–5 years old. Methods Premature infants admitted a tertiary pediatric hospital Shanghai, China, from 2016 2018 were enrolled. Prenatal information, during hospitalization, anthropometric...

Introduction Alzheimer’s disease (AD) is the most common neurodegenerative and characterised by cognitive impairment. Non-pharmacological treatments such as diet therapy have been widely investigated in studies on AD. Given synergistic effects of nutrients present foods, considering overall dietary composition rather than focusing a single nutrient may be more useful for evaluating relationship between AD cognition. The study aimed to assess efficacy different interventions (eg, ketogenic...

Purpose: Chordomas are locally aggressive tumors arising from notochordal remnants. Brachyury, a protein coded by T-gene, is crucial for chordoma cell proliferation. The aim of this study was to evaluate the effects glycogen synthase kinase 3 beta (GSK3β) activity on brachyury expression and growth survival skull base cells. Patients methods: In study, 16 paraffin-embedded specimens primary chordomas were analyzed phosphorylated GSK3β using immunohistochemistry. UM-Chor1 line derived clival...

Malnutrition is common in cirrhotic patients; however, there no gold standard for nutritional assessment this population. The aim of study was to develop a novel screening tool based on objective indicators patients chronically infected with hepatitis B virus (HBV).This cross-sectional study. Patients B-related cirrhosis were recruited. diagnosed by the presence any following conditions: Nutrition Risk Screening 2002 score greater than 3 points, Subjective Global Assessment grade or C, and...

To investigate the ability to form new bone and cartilage tissues of marrow mesenchymal stem cells (BMSC) derived from human condyle in vivo, search source seed constructing tissue engineering condyle.Bone was collected irrigation solution resected condyle, isolated by density gradient centrifugation then purified adherent separation cultured vitro. P3 or P4 BMSC populations were induced into osteoblasts chondroblast under inductive medium vitro seeded on porous coral scaffolds. The...