Dyspareunia is common in breast cancer survivors because of low estrogen. This study explored whether dyspareunia introital pain, preventable with analgesic liquid.In a randomized, controlled, double-blind trial, estrogen-deficient severe penetrative applied either saline or 4% aqueous lidocaine to the vulvar vestibule for 3 minutes before vaginal penetration. After 1-month blinded trial patient-assessed twice-per-week tampon insertion intercourse, all patients received 2 months an...

To assess whether primary and secondary vestibulodynia represent different pathologic pathways.

In Brief OBJECTIVE: To locate sites of genital tenderness in breast cancer survivors not using estrogen who experience dyspareunia and to test the hypothesis that is limited vulvar vestibule rather than vagina reversed by topical anesthetic. METHODS: Postmenopausal with moderate severe were recruited for an examination including randomization a double-blind intervention aqueous 4% lidocaine or normal saline 3 minutes areas found be tender. Comparisons changes patients' reported numerical...

In Brief OBJECTIVE: To assess whether premenopausal and postmenopausal vestibulodynia have different histologic features. METHODS: We conducted a retrospective analysis of vestibulectomy specimens from 21 women with compared them 88 patients (42 primary, 46 secondary). Women primary experienced pain at first introital touch secondary after an interval painless intercourse. Clinical records established the type vestibulodynia, duration symptoms, hormone status. Tissues were stained for...

To better understand the potential disease triggers of neurogenic inflammation in provoked localized vulvodynia (PLV), our objective was to determine whether types infiltrating lymphocytes were different vestibular biopsies from women with primary PLV, secondary and unaffected controls.Secondary retrospective analysis archived a series adult premenopausal PLV (n = 10), controls 4) performed. All study patients had severe entry dyspareunia for more than 1 year. Subjects excluded if pregnant,...

Abstract Objective To compare efficacies of two strengths estradiol cream applied to the vulvar vestibule and use silicone lubricant reduce intercourse pain scores in postmenopausal women with moderate/severe dyspareunia. Methods This pilot randomized comparative trial assigned 50 nightly applications cream, or 100 μg, for 12 weeks. We asked have lubricated penetration twice weekly, performing a tampon test. Pain, recorded dairies, was rated using 0-10 Numerical Rating Scale. assessed...

Abstract Objective: A common symptom of genitourinary syndrome menopause (GSM) is dyspareunia, attributed to vulvovaginal atrophy. Our objective was systematically describe the pain characteristics and anatomic locations tenderness in a cohort with moderate/severe dyspareunia likely due GSM. Methods: This cross-sectional study reports baseline data postmenopausal women screened for an intervention trial topical estrogen. Postmenopausal not using hormone therapy who had moderate or severe...

This study aimed to document cases of severe menopausal vulvar burning localized the vestibule.Seven postmenopausal women presented a clinic between 2007 and 2011 complaining debilitating constant pain. They were treated according findings. Statistical tools descriptive.The women's ages ranged from 56 79 years (mean age = 67 years). Pain had begun 1 4 before presentation 1.8 years) was vestibular. Five contraindications estrogen supplements. Only patient using estrogen; mean number menopause...

The study aimed to describe a case of low-grade fibromyxoid sarcoma arising from the vulva and discuss diagnostic challenges, clinical management, epidemiology this rare malignancy.A 36-year-old woman presented 3 separate emergency departments with complaints painful slowly enlarging vulvar mass. Eventual gynecologic referral resulted in excision 6-cm, noncystic Pathological diagnosis revealed sarcoma. Later, right radical hemivulvectomy ensured adequate margins, 2 years later, patient is...

To establish and compare the prevalence of group B streptococcus (GBS) colonization in vaginas nonobstetric women with without vaginitis.Cross-sectional analysis GBS vaginal culture status nonpregnant, estrogen-replete 18 years or older presenting for annual gynecological examinations infection. Subjects were classified into 3 groups: no vaginitis if symptoms absent examination results was normal; common (CV) microscopic revealed yeast, bacterial vaginosis, trichomonads; inflammatory (IV)...

INTRODUCTION: Research has focused on vaginal atrophy as the cause of dyspareunia in postmenopausal women. This study explored whether penetrative pain was prevented after hypoestrogenic patients applied analgesic liquid to vulvar vestibule. METHODS: In a randomized controlled, double-blind trial, estrogen-deficient breast cancer survivors with severe either saline or 4% aqueous lidocaine vestibule for 3 minutes before penetration. After 1-month blinded trial using diary documentation...

Objective The purpose of this study was to compare techniques and pain scales that assess tenderness in the vulvar vestibule provoked vestibulodynia, using cotton swab test a vulvalgesiometer, topical lidocaine solution with each. Materials Methods This randomized at specialty clinic evaluated tender vestibules reproductive-aged women vestibulodynia light rolling touch 6 sites vulvalgesiometer 2 sites, randomizing order initial tool. Participants reported Numerical Rating Scale 0–10 Verbal...

Scientific information is incomplete regarding the genitourinary syndrome of menopause. Both lower genital and urinary tracts are rich in receptors for reproductive hormones highly susceptible to waning ovarian at Symptoms dryness pain emerge late perimenopause, but they can also result earlier from cancer therapies or bilateral oophorectomy. Lower tract symptoms rise prevalence midlife increase further with advancing age. Because senescence typically followed by years aging, some...