A5056069621- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Esophageal Cancer Research and Treatment
- Urological Disorders and Treatments
- Metastasis and carcinoma case studies
- Urologic and reproductive health conditions
- Spinal Fractures and Fixation Techniques
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Diagnosis and Treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Sarcoma Diagnosis and Treatment
- S100 Proteins and Annexins
- Traumatic Brain Injury and Neurovascular Disturbances
- Helicobacter pylori-related gastroenterology studies
- Peptidase Inhibition and Analysis
- Cancer, Hypoxia, and Metabolism
- Colorectal Cancer Treatments and Studies
- Venous Thromboembolism Diagnosis and Management
- Urinary Bladder and Prostate Research
- Neonatal and fetal brain pathology
- CAR-T cell therapy research
- Soft tissue tumors and treatment
- Magnesium in Health and Disease
The First People's Hospital of Xiaoshan District, Hangzhou
2021-2025
Sir Run Run Shaw Hospital
2025
Zhejiang University
2025
Fudan University
2013-2024
Zhongshan Hospital
2013-2024
Sun Yat-sen University
2013-2024
The First Affiliated Hospital, Sun Yat-sen University
2013-2024
305 Hospital of People Liberation Army
2023
Baotou Central Hospital
2019
Shanghai Medical College of Fudan University
2012-2017
Abstract Overall survival (OS) benefits of neoadjuvant immunotherapy remain elusive in locally advanced esophageal squamous cell carcinomas (ESCC). Here, we reported the results a phase 1b trial PD-L1 blockade with adebrelimab resectable ESCC. Patients received two doses followed by surgery. The primary endpoints were safety and feasibility; secondary included pathologic complete response (pCR) OS. Our data showed feasibility had been met. Common treatment-related adverse events anorexia...
To examine the effect of proprotein convertase subtilisin/kexin type 9 (PCSK9) on gastric cancer (GC) progression and prognosis, to explore underlying mechanism.PCSK9 expression levels in human GC tissues were determined by quantitative real-time PCR, western blotting, immunohistochemical assay. PCSK9 serum detected enzyme-linked immunosorbent The relationships survival analyzed using Chi-square test, Kaplan-Meier analysis, Cox proportional hazards model. cell invasion, migration, apoptosis...
Infertility is increasingly linked to obesity, especially visceral fat accumulation. The Body Roundness Index (BRI) provides a precise quantification of body and but its implications for infertility risks diagnostic value are yet be fully determined. This study analyzed data from 1,305 married women aged 20-45 years, drawn the National Health Nutrition Examination Survey (NHANES). Logistic regression was utilized examine relationship between BRI infertility, incorporating univariate...
Despite extensive research on the impact of health factors and sleep, specific association between average daily sleep duration prevalence gallstones in adults has not been thoroughly investigated. This study analyzes data from 7,441 individuals NHANES 2017–2020 dataset, using exclusion criteria to refine participant pool. Employing multivariate logistic regression subgroup analyses while controlling for potential confounders, we assessed gallstones. Our results revealed a statistically...
Epithelioid inflammatory myofibroblastic sarcoma (EIMS), a specific subtype of tumors (IMT), is relatively rare malignant mesenchymal tumor with clinical features positive anaplastic lymphoma kinase (ALK), high invasiveness, treatment resistance and poor prognosis. Therefore, ALK inhibitors represent effective drugs for patients this type tumor. However, acquired remains inevitable without clear mechanism action therapeutic strategy to counteract this. Herein, chromosomal ALK-G1269A mutation...
A new staging system recently proposed by the IGCA has demonstrated a better capacity of stratifying different prognoses for gastric cancer than 7th edition AJCC (AJCC7). The aim this study was to evaluate efficacy in Chinese patients. Medical records patients with who received curative surgery our center from January 2003 December 2011 were reviewed retrospectively. All lesions staged according both AJCC7 and systems. Overall survival (OS) used as observation endpoint. One thousand five...
Gastrointestinal stromal tumor (GIST) is one of the most common mesenchymal tumors gastrointestinal tract. Though imatinib improves outcome, drug resistance remains major problem for extending patient survival. Genetic mutation targets known mechanism resistance. However, it cannot explain all phenomena resistance, and numerous additional mechanisms have been proposed to account in various model systems. In this study, we applied SYBR-green quantitative polymerase chain reaction-based array...
Aberrant β1, 6-N-acetylglucosaminyltransferase V (MGAT5) expression in malignant tissues has been reported to be involved the development of various cancers and their progression, through altering N-glycan branching. We aimed investigate clinical prognostic values MGAT5 improve risk stratification patients with gastric cancer. was retrospectively analyzed by immunohistochemistry three independent sets comprising 313 from China adenocarcinoma. Results were assessed for association features...
Lung cancer screening with computed tomography (CT) has been adopted worldwide. Consequently, there is an increase of some previously rarely reported lesions, like pleuropulmonary meningothelial proliferation (PMP), which included metastatic pulmonary meningiomas (MPMs), primary (PPMs) and minute meningothelial-like nodules (MPMNs). To date, the understanding clinical management PMP limited.We retrospectively searched (MPMs, PPMs, MPMNs) on medical database (May 2005 to April 2019) our...
Marfan syndrome is a multisystem connective tissue disorder of autosomal dominant inheritance, which typically involves manifestations the cardiovascular, skeletal, and ocular systems. Pulmonary involvement occurs less frequently. We report case 28-year-old woman suffering from hours sudden onset, progressive shortness breath right-sided chest pain. On physical examination, she presented decreased sound on right side chest, together with severe scoliosis marfanoid habitus. The computed...
Chemotherapy is the standard care for patients with incurable advanced gastric cancer. Whether or when addition of gastrectomy to chemotherapy improves survival cancer a single noncurable factor remains controversial. We aimed evaluate superiority following vs alone regarding overall (OS) in these patients.Patients from January 2008 December 2014 were retrieved our prospectively acquired database and retrospectively analyzed. The grouped terms treatment: chemotherapy.Four hundred fourteen...
To the editor: A 19-year-old man was referred to our institution with a 1-month history of iron deficiency anemia and hyperpyrexia. The lowest hemoglobin 4.0 g/dl highest temperature 40.6°C. clinical examination generally unremarkable. His abdomen nondistended except for mild epigastric tenderness on deep palpation. There were no other specific signs findings elicited. laboratory data including autoantibodies within reference ranges, low hemoglobin. computed tomography (Figure 1A) showed...
Fatty acid synthase (FAS) and human epidermal growth factor receptor 2 (HER2) are overexpressed in gastric cancer (GC), certain interactions have been found between FAS HER2. A total of 94 patients were enrolled the present study, each whom underwent a D2 radical surgery Zhongshan Hospital affiliated with Fudan University (Shanghai, China) 2000 2005. The expression HER2 was assessed by immunohistochemistry analysis tissue microarrays generated from GC non‑tumor tissues. All data analyzed...
Radiofrequency ablation (RFA) is a minimally invasive technology for the treatment of liver malignancies and used as an adjuvant therapy in patients with colorectal metastasis (CLM). This study enrolled total 49 CLM who underwent RFA treatment. Univariate multivariate analyses were performed using log-rank test Cox proportional hazard model, respectively. analysis showed that OS was closely correlated tumor size, frequency treatment, resection lesion, CEA levels before ( p < 0.05)....
The σ1A subunit of the adaptor protein 1 (AP1S1) participates in various intracellular transport pathways, especially maintenance copper homeostasis, which is pivotal carcinogenesis. It therefore rational to presume that AP1S1 might also be involved In this hospital-based case-control study, we investigated genetic susceptibility ESCC relation SNPs among Chinese population.A database containing a total 1303 controls and 1043 patients were retrospectively studied. analyzed based on ligation...