A5100422573- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adipose Tissue and Metabolism
- Peptidase Inhibition and Analysis
- Alzheimer's disease research and treatments
- Autoimmune Bullous Skin Diseases
- Metabolism, Diabetes, and Cancer
- Gut microbiota and health
- Mitochondrial Function and Pathology
- Diet and metabolism studies
- Sepsis Diagnosis and Treatment
- Urticaria and Related Conditions
- Metabolomics and Mass Spectrometry Studies
- Air Quality and Health Impacts
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Toxic Organic Pollutants Impact
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Ovarian function and disorders
- Chemotherapy-induced cardiotoxicity and mitigation
- Ocular Infections and Treatments
- Enzyme function and inhibition
- Histiocytic Disorders and Treatments
- Inflammatory Biomarkers in Disease Prognosis
- IgG4-Related and Inflammatory Diseases
Peking Union Medical College Hospital
2019-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
First Affiliated Hospital of Xi'an Jiaotong University
2016-2024
First Affiliated Hospital of Zhengzhou University
2024
National Clinical Research
2024
Academy of Medical Sciences
2024
Capital Medical University
2021-2023
Shanghai University of Traditional Chinese Medicine
2023
First Hospital of Jilin University
2023
Jilin University
2023
Abstract Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, inflammation. Accumulating evidence has shown that implicated in diseases, such as cancers, cardiac...
Background: Irisin, a novel exercise-induced myokine, was shown to mediate beneficial effects of exercise in osteoporosis. Microgravity is major threat bone homeostasis astronauts during long-term spaceflight, which results decreased formation. Methods: The hind-limb unloading mice model and random position machine are respectively used simulate microgravity vivo vitro. Results: We demonstrate that not only formation osteoblast differentiation decreased, but the expression fibronectin type...
Abstract Objective Researchers have revealed the combined functions of long noncoding RNAs (lncRNAs) and microRNA (miRNAs) in polycystic ovary syndrome (PCOS). This study aimed to understand role nuclear-enriched abundant transcript 1 (NEAT1) miR-381 involving insulin-like growth factor (IGF1) PCOS. Methods PCOS rat model was established by dehydroepiandrosterone induction. NEAT1, IGF1 expression ovarian granulosa cells patients tissues rats were tested. Bioinformatics website dual...
Xiang Sha Liu Junzi decoction (XSLJZD) is a famous traditional Chinese medicinal prescription for the treatment of functional dyspepsia (FD) in spleen deficiency. However, its therapeutic mechanism has not been fully clarified.The present study aimed to determine role mitochondrial quality control (MQC)-mediated gastrointestinal motility disorder FD treated with XSLJZD by using spleen-deficient rats and smooth muscle cells (GSMCs).In vivo, an deficiency syndrome model was established gastric...
Background Lingguizhugan decoction is a traditional Chinese medicine prescription that has been used to improve non-alcoholic fatty liver disease and its progressive form, steatohepatitis (NASH). However, the anti-NASH effects underlying mechanisms of remain unclear. Methods Male Sprague-Dawley rats were fed methionine- choline-deficient (MCD) diet induce NASH, then given orally for four weeks. NASH indexes evaluated by histopathological analysis biochemical parameters including serum...
Inorganic nitrate is an indispensable nutrient that has been used in experimental studies for the prevention and treatment of several diseases. However, short half-life limits its clinical application. To increase usability overcome challenges traditional combination drug discovery through large-scale high-throughput biological experiments, we developed a swarm learning-based prediction system identified vitamin C as choice to be combined with nitrate. Employing microencapsulation...
Abstract Aims Norepinephrine is recommended as a first‐line vasopressor agent in the haemodynamic stabilization of cardiogenic shock. The survival benefit norepinephrine therapy has not been demonstrated clinical practice, however. This study aimed to explore relationship between use and outcomes shock patients real‐world conditions. Methods results We conducted retrospective cohort based on Medical Information Mart for Intensive Care III (MIMIC‐III) database. Cardiogenic were enrolled...
Recently, mesenchymal stem cells (MSCs) are increasingly used as a panacea for multiple types of disease short effective treatment. Dozens clinical trials published demonstrated strikingly positive therapeutic effects MSCs. However, specific agent, little research has focused on the dynamic distribution MSCs after in vivo administration. In this study, we track systemically transplanted allogeneic bone marrow (BMSCs) normal rats through bioluminescence imaging (BLI) real time. Ex organ...
The neutrophil percentage-to-albumin ratio (NPAR) is a systemic inflammation-based predictor associated with many diseases' outcomes. Nevertheless, there are few studies on the relationship between NPAR and inflammatory markers, more importantly, prognostic value of in critically ill patients cardiovascular disease (CVD) remains unknown.The data this retrospective cohort study were from Medical Information Mart for Intensive Care III database (MIMIC-III) Second Affiliated Hospital Wenzhou...
Background: PLCG2 plays an important role in immune system signaling, and is expressed several cell types including microglia the brain. In 2017, genetic variant rs72824905 (p.Pro522Arg) gene (Phospholipase C Gamma 2) was associated with a reduced risk of Alzheimer's disease (AD). Here we investigated whether had similar protective effect on six other brain diseases. We further tested if increases likelihood longevity, since neurodegenerative diseases might associate general survival....
Abstract In the ALDH2 rs671 variant, a guanine changes to an adenine, resulting in dramatic decrease catalytic activity of enzyme. Population-based data are contradictory about whether this variant increases risk Alzheimer’s disease. East Asian populations, prevalence is 30–50%, making National Human Brain Bank for Development and Function (the largest brain bank Asia) important resource explore link between polymorphism disease pathology. Here, using 469 postmortem brains, we find that...
A microfluidic device was used to deliver chirped glucose waves find the entrainment regions of islets Langerhans.
Hereditary angioedema (HAE) is a rare but serious condition characterized by unpredictable and recurrent attacks affecting the skin mucosa. HAE has wide-ranging impacts on health-related quality of life (HRQoL) patients. This study aims to assess HRQoL Chinese patients with using 36-item Short Form Health Survey (SF-36v2) explore potential risk factors for low HRQoL. A total 104 (47 male 57 female) over age 18 living in China known diagnosis due C1-INH deficiency completed SF-36v2 (generic...
Invasive fungal disease (IFD) is a significant cause of morbidity and mortality in hospitalized patients. To maximize the efficacy voriconazole treatment, study established relationship between pharmacokinetic/pharmacodynamic (PK/PD) probability response optimized dosage regimen patients with IFD based on Monte Carlo simulation. Forty-four proven were involved this study. Among them, overall cure rate was 75% (33/44) there difference Cmin /MIC values lack (n = 11) those successful 33) (mean...
Telomeres are protein-DNA complexes at the tips of linear chromosomes. They protect DNA from end-to-end fusion and exonucleolytic degradation. Shortening telomeric during aging can generate dysfunctional telomeres, promoting tumorigenesis. More recent data indicate that both short long telomeres peripheral blood leukocyte (PBL) cells serve as prognostic biomarkers for cancer risk may be associated with survival patients solid cancers. Telomere length in PBL could also a potential biomarker...