A5100442043- Organic Light-Emitting Diodes Research
- Luminescence and Fluorescent Materials
- Pain Mechanisms and Treatments
- Ubiquitin and proteasome pathways
- Antibiotic Resistance in Bacteria
- Neurogenesis and neuroplasticity mechanisms
- Viral Infectious Diseases and Gene Expression in Insects
- Plant biochemistry and biosynthesis
- Antibiotics Pharmacokinetics and Efficacy
- Plant Gene Expression Analysis
- Synthesis and Properties of Aromatic Compounds
- Ion Transport and Channel Regulation
- Molecular Sensors and Ion Detection
- Ion channel regulation and function
- Adenosine and Purinergic Signaling
- Collaboration in agile enterprises
- Gynecological conditions and treatments
- PI3K/AKT/mTOR signaling in cancer
- Ion Channels and Receptors
- Ginseng Biological Effects and Applications
- Force Microscopy Techniques and Applications
- Organic Electronics and Photovoltaics
- Biochemical and biochemical processes
- Wnt/β-catenin signaling in development and cancer
- Lipid Membrane Structure and Behavior
Nanjing University
2010-2024
Nanjing General Hospital of Nanjing Military Command
2023-2024
Affiliated Hospital of Southwest Medical University
2024
Hubei University of Science and Technology
2019-2023
University of Electronic Science and Technology of China
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
Peking University
2022
Nanjing Drum Tower Hospital
2022
State Key Laboratory of Pharmaceutical Biotechnology
2017-2020
Model Animal Research Center
2017-2020
Pure organic materials with intrinsic room-temperature phosphorescence typically rely on heavy atoms or heteroatoms. Two different strategies towards constructing (RTP) species based upon the through-space charge transfer (TSCT) unit of [2.2]paracyclophane (PCP) were demonstrated. Materials bromine atoms, PCP-BrCz and PPCP-BrCz, exhibit RTP lifetime around 100 ms. Modulating PCP core non-halogen-containing electron-withdrawing units, PCP-TNTCz PCP-PyCNCz, successfully elongate to 313.59...
Abstract In this study, two pairs of chiral thermally activated delayed fluorescence (TADF) materials enabling circularly polarized luminescence (CPL) named R / S ‐ p BAMCN (rod‐shape) and o (helix‐shape) are prepared based on a new pair donor (D*), N 2 , ′‐diphenyl‐[1,1′‐binaphthalene]‐2,2′‐diamine ( BAM ), cyano (CN) acceptors. Due to the rigid molecular structure special intramolecular arrangement, TADF show high photoluminescence quantum efficiency (up 0.86) with narrow full‐width at...
Retinitis pigmentosa (RP) initiates with diminished rod photoreceptor function, causing peripheral and night-time vision loss. However, subsequent loss of cone function high-resolution daylight color is most debilitating. Visual pigment-rich outer segments (OS) undergo phagocytosis by the retinal pigment epithelium (RPE), RPE also acts as a blood-outer barrier transporting nutrients, including glucose, to photoreceptors. We provide evidence that contact between externalized...
Coumarins are the main bioactive compounds in Peucedanum praeruptorum Dunn, a common Chinese herbal medicine. Nevertheless, genes involved biosynthesis of core structure coumarin P. have not been identified yet. 4-Coumarate: CoA ligase (4CL) catalyzes formation hydroxycinnamates esters, and plays an essential role at divergence point from general phenylpropanoid metabolism to major branch pathway coumarin. Here, three novel putative 4CL (Pp4CL1, Pp4CL7, Pp4CL10) were isolated praeruptorum....
Direct emission of circularly polarized light from organic light-emitting diodes (OLEDs) is a research hotspot as it could increase the efficiency and significantly simplify device architecture OLED-based 3D displays. In this study, R/S-OBS-Cz R/S-OBS-TCz with axial chirality were efficiently prepared by using stable chiral octahydro-binaphthol unit, carbazole/3,6-ditert-butylcarbazole donors, 5,5,10,10-tetraoxide acceptor. The unit-acceptor-donor structure provides them not only thermally...
Abstract Background Tumor necrosis factor-α (TNF-α) is a pro-inflammatory cytokine involved in pain processing and hypersensitivity. It regulates not only the expression of variety inflammatory mediators but also functional activity some ion channels. Acid-sensing channels (ASICs), as key sensors for extracellular protons, are expressed nociceptive sensory neurons contribute to signaling caused by tissue acidosis. still unclear whether TNF-α has an effect on ASICs. Herein, we reported that...
Abstract Pure organic materials with intrinsic room‐temperature phosphorescence typically rely on heavy atoms or heteroatoms. Two different strategies towards constructing (RTP) species based upon the through‐space charge transfer (TSCT) unit of [2.2]paracyclophane (PCP) were demonstrated. Materials bromine atoms, PCP‐BrCz and PPCP‐BrCz, exhibit RTP lifetime around 100 ms. Modulating PCP core non‐halogen‐containing electron‐withdrawing units, PCP‐TNTCz PCP‐PyCNCz, successfully elongate to...
Coumarins are main active components of Peucedanum praeruptorum Dunn. Among them, methoxylated coumarin compound, such as bergapten, xanthotoxin and isopimpinellin, has high officinal value plays an important role in medicinal field. However, major issues associated with the biosynthesis mechanism coumarins remain unsolved no corresponding enzyme been cloned from P. praeruptorum. In this study, a local BLASTN program was conducted to find candidate genes transcriptome database using...
Abstract Understanding the direct interaction of nanostructures per se with biological systems is important for biomedical applications. However, whether regulate by targeting specific cellular proteins remains largely unknown. In present work, self‐assembling nanomicelles are constructed using small‐molecule oleanolic acid (OA) as a molecular template. Unexpectedly, without modifications functional ligands, OA significantly activate proteasome function directly binding to 20S subunit alpha...
An array-based method for profiling and quantification of multiple glycans on whole living cell surfaces was developed through combining DNA encoding technology with microarray. Using four kinds lectins as the model to recognize types surface glycans, specific barcode-lectin probes that contained endonuclease cutting site were designed. The had sequences complementary immobilized a microarray, respectively. After cells incubated mixture probes, these could bind interaction between...
Decreased expression but increased activity of PDK1 has been observed in neurodegenerative disease. To study vivo function neuron survival during cortical development, we generate forebrain-specific conditional knockout (cKO) mice. We demonstrate that cKO mice display striking loss and apoptosis. report exhibit deficits on several behavioral tasks. Moreover, show decreased activities for Akt mTOR. These results highlight an essential role endogenous the maintenance neuronal development.
By changing metallocycle members and replacing quinoline by benzo[ h ]quinoline with larger steric hindrance, the configurational stabilities of tetradentate Pt( ii ) enantiomers are improved good CPL properties for CP-OLEDs.
Protopanaxadiol (PPD), a main ginseng metabolite, exerts powerful anticancer effects against multiple types of cancer; however, its cellular targets remain elusive. Here, we synthesized cell-permeable PPD probe via introducing bifunctional alkyne-containing diazirine photo-crosslinker and performed photoaffinity labeling-based chemoproteomic study. We identified retinoblastoma binding protein 4 (RBBP4), chromatin remodeling factor, as an essential target in HCT116 colorectal cancer cells....
To evaluate the clinical efficacy of different species polymyxin drugs in treatment Carbapenem-Resistant Gram-negative bacilli (CR-GNB) resistant to ceftazidime-avibactam (CZA). Patients infected by CR-GNB strains and treated with were selected divided into colistin methanesulfonate (CMS) group sulfate/polymyxin B (CSPB) observe safety. 65 patients eventually included (CMS group, n = 29; CSPB 36). The efficacy, microbiological eradication rate 28-day mortality between two groups similar, no...
Summary Aims This study was to investigate whether cell proliferation and adult neurogenesis are affected at early neurodegenerative stage when neuron loss has not begun display. Methods Results Forebrain‐specific nicastrin ( NCT ) conditional knockout cKO mice were generated by crossing f/f with Ca MKII α ‐Cre Tg mice. BrdU used as a lineage tracer label proliferating neural progenitor cells NPC s). Immunohistochemistry IHC on indicated that the total number of positive (+) increased in...
The transition of apical progenitors (APs) to basal (BPs) is an important neurogenic process during cortical expansion. Presenilin enhancer 2 (Pen-2, also named as Psenen) a key subunit γ-secretase and has been implicated in neurodevelopmental disease. However, it remains unknown how Pen-2 may regulate the maintenance APs. To address this question, we generated conditional KO (cKO) mouse which specifically inactivated neural progenitor cells telencephalon. Both male female embryos were used....
Telencephalic radial glial progenitors (RGPs) are retained in the ventricular zone (VZ), niche for neural stem cells during cortical development. However, underlying mechanism is not well understood. To study whether protein phosphatase 2A (PP2A) may regulate above process, we generate Ppp2cα conditional knockout (cKO) mice, which PP2A catalytic subunit α (PP2Acα) inactivated progenitor dorsal telencephalon. We show that RGPs ectopically distributed areas outside of VZ cKO embryos. Whereas...
It has been shown that PP2A is critical for apoptosis in neural progenitor cells. However, it remains unknown whether required neuronal survival. To address this question, we generated forebrain-specific Ppp2cα knockout (KO) mice. We show KO mice display robust and inflammatory responses the postnatal cortex. Previous evidence revealed PD98059 a potent ERK inhibitor may protect brain against cell death after cardiac arrest. study have any effects on mice, latter was treated with inhibitor....