A5035135881- Neurogenesis and neuroplasticity mechanisms
- Nuclear Receptors and Signaling
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Photoreceptor and optogenetics research
- Ubiquitin and proteasome pathways
- Genomic variations and chromosomal abnormalities
- Alzheimer's disease research and treatments
- MicroRNA in disease regulation
- Transport Systems and Technology
- Quantum optics and atomic interactions
- RNA Research and Splicing
- Retinal Development and Disorders
- Spectroscopy and Quantum Chemical Studies
- Developmental Biology and Gene Regulation
- Chronic Myeloid Leukemia Treatments
- Evaluation and Optimization Models
- Genetic Neurodegenerative Diseases
- Cellular Mechanics and Interactions
- ATP Synthase and ATPases Research
- Microtubule and mitosis dynamics
Southeast University
2005-2024
Nanjing University
2014-2019
Model Animal Research Center
2014-2019
State Key Laboratory of Pharmaceutical Biotechnology
2016
Abstract Minocycline is a broad-spectrum tetracycline antibiotic. A number of preclinical studies have shown that minocycline exhibits neuroprotective effects in various animal models neurological diseases. However, it remained unknown whether effective to prevent neuron loss. To systematically evaluate its effects, was used treat Dicer conditional knockout (cKO) mice which display age-related The drug given mutant prior the occurrence neuroinflammation and neurodegeneration treatment had...
Abstract Weak signal amplification is extremely important in biological systems (such as brain, nerve cells, gene regulatory networks), which relates to coding and processing. This study incorporates intra-layer coupling within a simple Y-shaped unidirectional chain means of exploring the effect small changes network structure on propagation weak signals, where nodes are treated bistable oscillators. It found that when below critical threshold inter-layer at medium range, transmission...
The balance between cell proliferation and differentiation is essential for maintaining the neural progenitor pool brain development. Although mechanisms underlying at transcriptional level have been studied intensively, post-transcriptional regulation of remains largely unclear. Here, we show that deletion alternative splicing regulator PQBP1 in striatal progenitors results defective development due to impaired neurogenesis spiny projection neurons (SPNs). Pqbp1-deficient exhibit declined...
Tau hyperphosphorylation plays a critical role in neurodegenerative diseases [EMBO Mol Med. 6:1142-60, 2014; Annu Rev Neurosci. 24:1121-59, 2001]. Recent evidence has shown that Akt is down-regulated AD [J Pathol. 225:54-62, 2011]. However, it remained unknown which pathological process, e.g. tau pathology or neuron death, may contribute to. In this study, Cre-loxP technique was employed to generate viable three isoforms conditional knockout (Akt cTKO) mouse total levels were dramatically...
Summary Aims This study was to investigate whether cell proliferation and adult neurogenesis are affected at early neurodegenerative stage when neuron loss has not begun display. Methods Results Forebrain‐specific nicastrin ( NCT ) conditional knockout cKO mice were generated by crossing f/f with Ca MKII α ‐Cre Tg mice. BrdU used as a lineage tracer label proliferating neural progenitor cells NPC s). Immunohistochemistry IHC on indicated that the total number of positive (+) increased in...
The transition of apical progenitors (APs) to basal (BPs) is an important neurogenic process during cortical expansion. Presenilin enhancer 2 (Pen-2, also named as Psenen) a key subunit γ-secretase and has been implicated in neurodevelopmental disease. However, it remains unknown how Pen-2 may regulate the maintenance APs. To address this question, we generated conditional KO (cKO) mouse which specifically inactivated neural progenitor cells telencephalon. Both male female embryos were used....
Heterotrimeric G proteins mediate a variety of signaling processes by coupling protein-coupled receptors to intracellular effector molecules. In
Metabotropic glutamate receptor-dependent long-term depression (mGluR-LTD) occurs in diverse brain regions and contributes to the plasticity of behavior, learning, memory. mGluR-LTD relies on rapid (in minutes) local protein synthesis. Here, we describe a detailed protocol for delivering an interfering peptide into adult mouse hippocampus. The delivered disrupts interaction between polyglutamine binding 1 eukaryotic elongation factor 2, resulting impaired hippocampal mGluR-LTD-associated...