A5100356328- Drug-Induced Hepatotoxicity and Protection
- Pesticide Exposure and Toxicity
- Head and Neck Cancer Studies
- Poisoning and overdose treatments
- Medical Imaging and Analysis
- Lung Cancer Treatments and Mutations
- Inflammatory Bowel Disease
- Liver Disease Diagnosis and Treatment
- Intracerebral and Subarachnoid Hemorrhage Research
- Diverticular Disease and Complications
- GABA and Rice Research
- Sepsis Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Acute Kidney Injury Research
- Neurosurgical Procedures and Complications
- Systemic Lupus Erythematosus Research
- Hematological disorders and diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- Cancer-related molecular mechanisms research
- Spine and Intervertebral Disc Pathology
- Anorectal Disease Treatments and Outcomes
- Medicinal Plant Pharmacodynamics Research
- Oral health in cancer treatment
- Omental and Epiploic Conditions
- Thermal Regulation in Medicine
Wuhan University
2025
Zhongnan Hospital of Wuhan University
2025
Hubei Provincial Center for Disease Control and Prevention
2025
University of Michigan
2021-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2025
Peking Union Medical College Hospital
2009-2025
East China Jiaotong University
2025
Kunming Children's Hospital
2023
Xi'an Honghui Hospital
2023
Xi'an Jiaotong University
2023
Purpose To determine the response rate, survival and toxicity of infusional cisplatin plus fluorouracil (CF) versus paclitaxel (CP) in patients with incurable squamous cell cancer head neck, hypothesis that CP is superior. Patients Methods Two hundred eighteen locally advanced, recurrent, or metastatic disease were randomly assigned to CF (cisplatin 100 mg/m 2 day 1 1,000 /24 hours by continuous intravenous infusion through 4) 75 175 over 3 on 1). Cycles repeated every weeks until...
Abstract BACKGROUND: A randomized phase 2 study was performed to investigate the efficacy/toxicity of combining concomitant boost radiation and weekly carboplatin/paclitaxel with or without amifostine in patients locally advanced squamous cell carcinoma head neck (SCCHN). METHODS: Patients newly diagnosed, stage III IV SCCHN received 4 doses carboplatin (area under curve, 1.5) paclitaxel (45 mg/m ) concurrently consisting 72 grays 42 fractions over 6 weeks (every day for 18 days, twice a 12...
Introduction: The prevalence of thyroid nodules has been increasing, and there are few research data on the risk factors in Chinese population. In this study, we aimed to determine by retrospectively investigating physical examination records a cohort “healthy” individuals Beijing, China. Methods: This was retrospective cross-sectional study. database Medical Examination Centre (MEC) searched. Physical data, blood test ultrasound etc., from 2015 2017 were accessed. Only those that recorded...
Emerging evidence highlights the role of thyroid hormones in cancer, though findings are controversial. Research on thyroid-related traits lung carcinogenesis is limited. Using UK Biobank data, we conducted bidirectional Mendelian randomization (MR) to assess causal links between cancer risk and dysfunction (hypothyroidism/hyperthyroidism) or function (free thyroxine [FT4], normal-range TSH). Furthermore, smoking-behavior stratified MR analysis, evaluated mediating effect phenotypes...
The Chinese population are at an increased risk of autoimmune hepatitis (AIH). aims this study were to determine the demographic and clinical features AIH in China. A total 83 patients with diagnosed by revised scoring system re‑analyzed, presentations among different ages compared. classified according age presentation. occurred aged ≤30 years (9.6%), 31‑39 (10.8%), 40‑49 (16.9%), 50‑59 (31.3%) ≥60 (31.3%). There no differences form presentation, concurrent diseases, cirrhosis distribution...
Body mass index (BMI) change after a lung cancer diagnosis has been associated with non-small cell (NSCLC) survival. This study aimed to quantify the association based on large-scale observational study.Included in were 7,547 patients NSCLC prospectively collected BMI data from Massachusetts General Hospital and Brigham Women's Hospital/Dana-Farber Cancer Institute. Cox proportional hazards regression time-dependent covariates was used estimate effect of time-varying postdiagnosis rate (%...
Periductal mastitis (PDM) is a complex benign breast disease with prolonged course and high risk of recurrence after treatment. There are many available treatments for PDM, but none widely accepted. This study aims to evaluate the various treatment failure rates (TFR) different invasive measures by looking at persistence In this way, it sets out inform better clinical decisions in PDM.We searched PubMed, Embase, Cochrane Library databases eligible studies about regimens provided PDM patients...
This study aimed to determine the effects of emodin on viability, proliferation and apoptosis human pulmonary artery smooth muscle cells (PASMCs) under hypoxia explore underling molecular mechanisms.PASMCs were cultured in a hypoxic environment (1% oxygen) then treated with emodin. Cell evaluated using CCK-8 assay, EdU staining western blot Mito-tracker red CMXRos Annexin V-FITC detection assay. The microRNA (miRNA)/mRNA protein expression levels assessed by quantitative real-time PCR...
Recent global estimates of deaths from poisoning suggest that more than 150,000 occur each year in China pesticide alone. One response the Chinese government has been to set up Poison Control Centers province improve management. Unfortunately, epidemiology is still unclear and there are no specialist clinical toxicologists take lead dealing with massive loss life. The objective this article survey situation toxicology give some suggestions for its development.
To observe the changes in platelet parameters including volume distribution width (PDW), crit (PCT) and large cell ratio (PLCR) patients with septic shock, to approach its predictive effect on prognosis obtain indexes predicting quickly conveniently.A retrospective study was conducted. Data from shock admitted Peking Union Medical College Hospital January 1 December 31, 2012 were collected. The divided into two groups according prognosis. general condition, laboratory parameters, infection,...
Purpose: To evaluate the safety and curative effect of selective intraarterial rAd-p53 infusion combined with chemotherapy for locally advanced HNC, 23 patients were enrolled into a prospective clinical phase II study. Materials Method: Twenty-three locoregionally SCC or ACC subdivided three groups. All underwent unilateral bilateral retrograde catheterization ECA. Through arterial pumps, chemotherapeutic agents was administrated to group I (7 patients), (6 III Results: The complete response...
Objective To study the clinical characteristics of 2019 coronavirus (2019-nCoV) pneumonia patients and make a feasible screening process in fever clinic. Methods Epidemiologic features, presentation, laboratory findings image features screened were retrospectively collected analyzed. Results Totally, 46 screened, 9 them laboratory-confirmed 2019-nCoV infection, others defined as laboratory-excluded patients. Laboratory-confirmed had higher frequency travelling or residence Wuhan...