Elizabeth Loehrer
A5024103445- Ovarian cancer diagnosis and treatment
- Migraine and Headache Studies
- Cancer Genomics and Diagnostics
- Neuroscience of respiration and sleep
- Esophageal Cancer Research and Treatment
- Functional Brain Connectivity Studies
- Cancer Mechanisms and Therapy
- Treatment of Major Depression
- Intracerebral and Subarachnoid Hemorrhage Research
- Renal cell carcinoma treatment
- Microtubule and mitosis dynamics
- Dementia and Cognitive Impairment Research
- Cancer-related gene regulation
- Cancer-related Molecular Pathways
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- RNA modifications and cancer
- Acute Ischemic Stroke Management
- Vitamin D Research Studies
- Esophageal and GI Pathology
- Neurological Disease Mechanisms and Treatments
- Chromatin Remodeling and Cancer
- Cerebrovascular and Carotid Artery Diseases
- Genetic Associations and Epidemiology
- Renal and related cancers
Erasmus MC
2013-2025
Amsterdam University Medical Centers
2025
Radboud University Nijmegen
2025
Erasmus MC Cancer Institute
2025
Harvard University
2015-2021
Broad Institute
2020
University of Bristol
2020
Medical Research Council
2020
Massachusetts General Hospital
2020
Boston University
2015
An artificial intelligence system at mammography effectively selected women with intermediate risk for breast cancer development (up to 50% lifetime risk) supplemental MRI screening.
Amplification of cyclin E1 (CCNE1) is associated with poor outcome in breast, lung, and other solid cancers, the most prominent structural variant primary treatment failure high-grade serous ovarian cancer (HGSC). We have previously shown that CCNE1-amplified tumors show amplicon-dependent sensitivity to CCNE1 suppression. Here, we explore targeting CDK2 as a novel therapeutic strategy cancers mechanisms resistance.We examined effect suppression using RNA interference small-molecule...
Abstract High-grade serous cancer (HGSC), the most common subtype of ovarian cancer, often becomes resistant to chemotherapy, leading poor patient outcomes. Intratumoral heterogeneity occurs in nearly all solid cancers, including contributing development resistance mechanisms. In this study, we examined spatial and temporal genomic variation HGSC using high-resolution single-nucleotide polymorphism arrays. Multiple metastatic lesions from individual patients were analyzed along with 22...
Abstract Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in prophylaxis are unknown. Leveraging large-scale summary statistics for ( N cases / controls = 59,674/316,078) BP 757,601), we find positive genetic correlations diastolic (DBP, r g 0.11, P 3.56 × 10 −06 ) systolic (SBP, 0.06, 0.01), but not pulse (PP, −0.01, 0.75). Cross-trait meta-analysis reveals 14 shared loci ≤ 5 −08 ), nine which replicate < 0.05) UK Biobank. Five...
CKD is linked with various brain disorders. Whereas integrity dependent on cerebral perfusion, the association between kidney function and blood flow has yet to be determined. This study was performed in framework of population-based Rotterdam Study included 2645 participants mean age 56.6 years (45% men). We used eGFR albumin-to-creatinine ratio assess phase-contrast magnetic resonance imaging basilar carotid arteries measure flow. Participants had an average (SD) 86.3 (13.4) ml/min per...
The question remains whether reduced cerebral blood flow (CBF) leads to brain atrophy or vice versa. We studied the longitudinal relation between CBF and volume in a community-dwelling population. In Rotterdam Study, 3011 participants (mean age 59.6 years (s.d. 8.0)) underwent repeat magnetic resonance imaging quantify at two time points. Adjusted linear regression models were used investigate bidirectional volume. found that smaller baseline was associated with steeper decrease whole...
Abstract Background Nearly a fifth of the world’s population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods To further elucidate these factors, we conducted genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between headache and 47 traits UK Biobank. We then tested possible causality phenotypes migraine, Mendelian randomization. In addition, attempted replication our findings in an independent...
Migraine is a highly common and debilitating disorder that often affects individuals in their most productive years of life. Previous studies have identified both genetic variants brain morphometry differences associated with migraine risk. However, the relationship between has not been examined on level, causal nature association structure risk determined. Using largest available genome-wide to date, we overlap intracranial volume, as well regional volumes nine subcortical structures. We...
B‐cell translocation gene 2 ( BTG2 ) is a tumour suppressor protein known to be downregulated in several types of cancer. In this study, we investigated potential role for early‐stage non‐small cell lung cancer (NSCLC) survival. We analysed methylation data from 1230 NSCLC patients five international cohorts, as well expression 3038 cases multiple cohorts. Three CpG probes (cg01798157, cg06373167, cg23371584) that detected hypermethylation tissues were associated with lower overall The...
Abstract Background: Female patients with Peutz-Jeghers syndrome (PJS) have an increased risk of breast cancer (BrCa), and surveillance is recommended. However, clinicopathological features their tumors prognosis are lacking. To facilitate more precise future guideline development, we evaluated these data. Methods: We conducted international survey for InSiGHT members to collect retrospective data on PJS diagnosed cancer. Results: received 23 responses, including three centers BrCa patients....
Introduction Observations that migraine increases risk of cardiovascular disease and ischemic brain changes may suggest sustained vascular differences between migraineurs controls. In a population-based setting, we compared cerebral blood flow in the attack-free period Methods Between 2006 2008, 2642 participants, aged 45–65, from Rotterdam Study completed questionnaire had complete usable MRI data. Participants were classified into controls (N = 2033), probable 153), or 456). Using 2D phase...
Abstract Migraine is a debilitating neurological disorder affecting around 1 in 7 people worldwide, but its molecular mechanisms remain poorly understood. Some debate exists over whether migraine disease of vascular dysfunction, or result neuronal dysfunction with secondary changes. Genome-wide association (GWA) studies have thus far identified 13 independent loci associated migraine. To identify new susceptibility loci, we performed the largest genetic study to date, comprising 59,674 cases...
Body mass index (BMI) change after a lung cancer diagnosis has been associated with non-small cell (NSCLC) survival. This study aimed to quantify the association based on large-scale observational study.Included in were 7,547 patients NSCLC prospectively collected BMI data from Massachusetts General Hospital and Brigham Women's Hospital/Dana-Farber Cancer Institute. Cox proportional hazards regression time-dependent covariates was used estimate effect of time-varying postdiagnosis rate (%...
Abstract Background We examined whether body mass index (BMI) changes in adulthood, prior to disease onset, are associated with overall survival among esophageal adenocarcinoma patients. Methods included 285 histologically confirmed patients a complete baseline BMI questionnaire. Using extended Cox regression models, we obtained adjusted hazard ratios (HRs) for the associations between and at diagnosis, 6 months before self‐reported average adult BMI, ΔBMI (BMI diagnosis minus BMI),...
Objective To investigate the association of migraine genetic variants with cerebral blood flow (CBF). Background Migraine is a common disorder many and non‐genetic factors affecting its occurrence. The exact pathophysiological mechanisms underlying disease remain unclear, but are known to involve hemodynamic vascular disruptions. Recent genome‐wide studies have identified 44 in 38 loci that affect risk migraine, which provide opportunity further disentangle these mechanisms. Methods We...
Abstract Cerebral microbleeds are considered an imaging marker of cerebral small vessel disease. The location is thought to reflect the underlying pathology. Microbleeds in deep and infratentorial region hypertensive arteriopathy whereas lobar associated clinically with amyloid angiopathy (CAA). Aside from patient populations, frequently observed seemingly asymptomatic populations. Moreover, many elderly, both clinical preclinical have multiple coexisting pathologies their brains, which...