A5051207655- Musculoskeletal pain and rehabilitation
- Pain Mechanisms and Treatments
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Pediatric Pain Management Techniques
- Migraine and Headache Studies
- Pain Management and Placebo Effect
- Pregnancy-related medical research
- Neuroscience of respiration and sleep
- Maternal and Perinatal Health Interventions
- Anesthesia and Pain Management
- Exercise and Physiological Responses
- Heart Rate Variability and Autonomic Control
- Physical Activity and Health
- Traumatic Brain Injury Research
- Psychosomatic Disorders and Their Treatments
- Spine and Intervertebral Disc Pathology
- Thermoregulation and physiological responses
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Gastrointestinal motility and disorders
- Genetic Associations and Epidemiology
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Pain Management and Opioid Use
- Antimicrobial Resistance in Staphylococcus
- Cardiovascular and exercise physiology
Norwegian Institute of Public Health
2016-2025
Oslo University Hospital
2016-2025
University of Calgary
2022-2024
Medical University of South Carolina
2022
Alberta Bible College
2021
UiT The Arctic University of Norway
2017-2021
Harvard University
2020
Nasjonalforeningen for Folkehelsen
2019-2020
Massachusetts General Hospital
2020
University of Oslo
1999-2019
Large individual differences in pain sensitivity present a challenge for medical diagnosis and may be of importance the development chronic pain. Variance is partially mediated by genetic factors, but extent this contribution uncertain. We examined cold-pressor contact heat 53 identical (MZ) 39 fraternal (DZ) twin pairs, 4 single twins to determine heritability two phenotypes, which same environmental factors affect both modalities. An estimated 60% variance 26% was genetically mediated....
Population-based data on the prevalence of persistent postsurgical pain are scarce. This study aimed to assess in a general population and describe associated physical, social, psychological factors, including symptoms nerve injury sensitization. A cross-sectional survey was performed northern Norway with questionnaire items covering surgery, pain, sensory abnormalities area surgery. Of 12,982 participants, 24.0% (3111) had undergone one or more surgical procedures during 3 years preceding...
Sleep problems and pain are major public health concerns, but the nature of association between 2 conditions is inadequately studied. The aim this study was to determine whether a range sleep measures associated with experimental increased sensitivity. A cross-sectional large population-based from 2007 2008, Tromsø 6 study, provided data 10,412 participants (age: mean [SD], 58 [13] years; 54% women). Self-reported information on duration, onset latency (SOL), efficiency, as well frequency...
Abstract Background The aim of this prospective study was to investigate the role labor pain and overall birth experience in development posttraumatic stress symptoms a comprehensive framework. Methods sample ( N = 1893) comprised women with vaginal delivery drawn from Akershus Birth Cohort, which targeted all scheduled give at University Hospital Norway. Questionnaires were given three different stages: pregnancy weeks 17 32, maternity ward, 8 postpartum. Data also obtained hospital's...
Mice with experimental nerve damage can display long‑lasting neuropathic pain behavior. We show here that 4 months and later after injury, male but not female mice displayed telomere length (TL) reduction p53‑mediated cellular senescence in the spinal cord, resulting maintenance of associated decreased lifespan. Nerve injury increased number p53‑positive cord neurons, astrocytes, microglia, only microglia was increase male‑specific, matching a robust sex specificity TL this cell type, which...
Abstract Background Chronic pain is a condition with severe impact on many aspects of life, including work, functional ability and quality thereby reducing physical, mental social well‐being. Despite the high prevalence burden chronic pain, it has received disproportionally little attention in research public policy societal costs remain largely unknown. This study aimed to describe long‐term healthcare work absence individuals without self‐identified pain. Methods The population were...
Summary Chronic pain is associated with both increased hypertension prevalence and impaired blood pressure–related hypoalgesia in a general population sample. Resting pressure (BP) inversely related to sensitivity individuals free of chronic pain, reflecting homeostatic interactions between cardiovascular modulatory systems. Several laboratory studies indicate that BP-related diminished patients, suggesting dysfunction these interacting Separate epidemiological findings reveal elevated the...
Abstract Blood pressure (BP) was inconsistently associated with migraine and the mechanisms of BP-lowering medications in prophylaxis are unknown. Leveraging large-scale summary statistics for ( N cases / controls = 59,674/316,078) BP 757,601), we find positive genetic correlations diastolic (DBP, r g 0.11, P 3.56 × 10 −06 ) systolic (SBP, 0.06, 0.01), but not pulse (PP, −0.01, 0.75). Cross-trait meta-analysis reveals 14 shared loci ≤ 5 −08 ), nine which replicate < 0.05) UK Biobank. Five...
Physical activity (PA) might influence the risk or progression of chronic pain through tolerance. Hence, we aimed to assess whether habitual leisure-time PA level and change affects tolerance longitudinally in population. Our sample (n = 10,732; 51% women) was gathered from sixth (Tromsø6, 2007-08) seventh (Tromsø7, 2015-16) waves prospective population-based Tromsø Study, Norway. Level (sedentary, light, moderate, vigorous) derived questionnaires; experimental measured by cold-pressor test...
Heat induced pain has been shown to follow a positively accelerating power function for groups of subjects, yet the extent which this applies individual subjects is unknown. Statistical methods were developed assessing goodness fit and reliability data from with aim using such functions characterizing differences in heat-pain sensitivity. 175 rated ascending random series contact heat stimuli visual analogue scales intensity (VAS-I) unpleasantness (VAS-A). Curve fitting showed excellent...
In a large survey incorporating medical examination (N=12,981), information on chronic pain and surgery was collected, sensitivity to different modalities tested. Tolerance the cold pressor test analysed with survival statistics for 10,486 individuals, perceived intensity calculated 10,367 heat threshold assessed 4,054 pressure 4,689 individuals. Persistent post-surgical pain, defined by self-report, associated lower tolerance (sex-adjusted hazard ratio=1.34, 95% confidence...
The aim of this study was to examine whether irritable bowel syndrome (IBS) is associated with increased somatic pain sensitivity in a large population-based sample and test association independent sex, age, comorbid chronic pain, psychological distress. Pain tests included assessment heat-pain threshold (N=4054) pressure-pain (N=4689) cold-pressor intensity tolerance (N=10,487). Cox regression analysis variance (ANOVA) were used assess the relationship between IBS stepwise multivariate...
Abstract Heart rate variability (HRV) and baroreflex sensitivity (BRS) are indexes reflecting the ability to maintain cardiovascular homeostasis amidst changing conditions. Evidence primarily from small studies suggests that both HRV BRS may be reduced in individuals with chronic pain (CP), potential implications for risk. We compared between CP (broadly defined) pain-free controls a large unselected population sample. Participants were 1143 reporting clinically meaningful 5640 who completed...
Background The nature of the relationship between fatigue and its risk factors is poorly understood. In present study genetic environmental association anxiety-depression, musculoskeletal (MS) pain was examined, role neuroticism as a shared factor that may possibly explain co-occurrence these phenotypes investigated in combined cross-sectional longitudinal twin design. Methods sample consisted 746 monozygotic (MZ) 770 dizygotic (DZ) twins age group 50–65 (mean = 57.11 years, SD 4.5)....
Background . Chronic pain is associated with increased morbidity and mortality, predominated by cardiovascular disease cancer. Investigating related risk factor measures may elucidate the biological burden of chronic pain. Objectives We hypothesized that severity would be positively composite. Methods Data from 12,982 participants in 6th Tromsø study were analyzed. Questionnaires included demographics, health behaviors, medical comorbidities, symptoms. The composite was comprised body mass...
Increased pain sensitivity is a putative risk factor for chronic and consequently analgesic use. Conversely, use may be cause of increased sensitivity, e.g., through opioid-induced hyperalgesia. We aimed to study the association between in general population, test hypothesis that baseline future persistent The Tromsø Study (2007–08), population-based health study, was linked with eight years prescription data from Norwegian Prescription Database. cold pressor completed 10,486 participants...
Abstract The aim of this study was to examine whether increases in severity subclinical inflammation, measured by high-sensitivity C-reactive protein (hs-CRP), increased experimental pain sensitivity, cold-pressor tolerance, and test relationship is independent chronic pain. A large population-based from 2007 2008, the sixth Tromsø Study, provided data 12,981 participants. For present analysis, complete for 10,274 participants (age: median 58 years) were available. main outcome measure...
Background Physical inactivity and chronic pain are both major public health concerns worldwide. Although the benefits of regular physical exercise well-documented, few large epidemiological studies have investigated association between specific domains in young adults. We sought to investigate frequency, intensity duration exercise, pain. Methods Data stem from SHoT2018-study, a national survey for higher education Norway, which 36,625 fulltime students aged 18–35 years completed all...
Abstract Background Nearly a fifth of the world’s population suffer from migraine headache, yet risk factors for this disease are poorly characterized. Methods To further elucidate these factors, we conducted genetic correlation analysis using cross-trait linkage disequilibrium (LD) score regression between headache and 47 traits UK Biobank. We then tested possible causality phenotypes migraine, Mendelian randomization. In addition, attempted replication our findings in an independent...
Quantitative sensory testing (QST) has been used to characterize pain sensitivity in individuals with and without conditions. Research remains limited pediatric populations, hindering the ability expand utility of QST toward its potential application clinical settings predictive value. The aims this study were examine using adolescents chronic compared identify predictors sensitivity. A population-based conducted from 2010 2011 provided data on 941 adolescents, 197 classified as having 744...
P2X7 is a nonselective cation channel activated by extracellular ATP. activation contributes to the proinflammatory response injury or bacterial invasion and mediates apoptosis. Recently, function has been linked chronic inflammatory neuropathic pain. may contribute pain modulation both effects on peripheral tissue underlying clinical states, through alterations in central nervous system processing, as suggested animal models. To further test its role sensitivity, we examined whether...
Abstract Epidemiological literature on the relationship between physical activity and chronic pain is scarce inconsistent. Hence, our aim was to assess applying comprehensive methodology, including self-reported accelerometer measures of different severity levels pain. We used data from Tromsø Study (2015-2016). All residents in municipality, aged 40 years older were invited participate (n = 32,591, 51% women). A total 21,083 (53%) women reported questionnaires. Additionally, 6778...