Estrella Morenas‐Rodríguez
A5054688310- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Genetic Associations and Epidemiology
- Bioinformatics and Genomic Networks
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurological diseases and metabolism
- Genomics and Rare Diseases
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Tryptophan and brain disorders
- Health, Environment, Cognitive Aging
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and genetic disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Metabolomics and Mass Spectrometry Studies
- Advanced Neuroimaging Techniques and Applications
- Genetic Mapping and Diversity in Plants and Animals
- Lysosomal Storage Disorders Research
- Parathyroid Disorders and Treatments
- Immune cells in cancer
German Center for Neurodegenerative Diseases
2018-2024
Institut für Urheber- und Medienrecht
2023
Hospital Universitario 12 De Octubre
2022-2023
Hospital de Sant Pau
2014-2022
Universitat Autònoma de Barcelona
2014-2022
Biomedical Research Networking Center on Neurodegenerative Diseases
2014-2022
Ludwig-Maximilians-Universität München
2018-2022
Munich Cluster for Systems Neurology
2018-2022
Instituto de Salud Carlos III
2015-2022
Centro de Investigación Biomédica en Red
2014-2022
TREM2 is a transmembrane receptor that predominantly expressed by microglia in the central nervous system. Rare variants gene increase risk for late-onset Alzheimer's disease (AD). Soluble (sTREM2) resulting from shedding of ectodomain can be detected cerebrospinal fluid (CSF) and surrogate measure TREM2-mediated function. CSF sTREM2 has been previously reported to at different clinical stages AD, however, alterations relation Amyloid β-peptide (Aβ) deposition or additional pathological...
Higher CSF sTREM2 concentrations are associated with slower rates of cognitive decline in subjects Alzheimer’s disease.
Common variants in the microglia-specific MS4A gene cluster modify risk for late-onset Alzheimer’s disease and modulate extracellular soluble TREM2.
Therapeutic modulation of TREM2-dependent microglial function might provide an additional strategy to slow the progression Alzheimer's disease. Although studies in animal models suggest that TREM2 is protective against pathology, its effect on tau pathology and potential beneficial role people with disease still unclear. Our aim was study associations between dynamics soluble TREM2, as a biomarker signalling, amyloid β (Aβ) deposition, tau-related neuroimaging markers, cognitive decline,...
Abstract Atherosclerosis is a chronic disease of the vascular wall driven by lipid accumulation and inflammation in intimal layer arteries, its main complications—myocardial infarction stroke—are leading cause mortality worldwide 1,2 . Recent studies have identified triggering receptor expressed on myeloid cells 2 (TREM2), lipid-sensing regulating cell functions 3 , to be highly macrophage foam experimental human atherosclerosis 4 However, role TREM2 not fully known. Here we show that...
Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment 41), AD dementia 31) patients. Participants underwent a lumbar puncture 3 T magnetic resonance imaging. Healthy were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N 220; stage 1, 25; 2/3, 9). assessed the cortical MD, FW,...
<h3>Objective:</h3> To investigate CSF markers involved in amyloid precursor protein processing, neuronal damage, and neuroinflammation the preclinical stages of Alzheimer disease (AD) participants with suspected non-Alzheimer pathology (SNAP). <h3>Methods:</h3> We collected from 266 cognitively normal volunteers participating a cross-sectional multicenter study (the SIGNAL study) to processing (Aβ42, sAPPβ, β-secretase activity), damage (total-tau [t-tau], phospho-tau [p-tau]), (YKL-40)....
Background: In progressive multiple sclerosis (MS), glial activation is thought to be a relevant mechanism of disability progression. Therefore, in vivo assessment the cell activity is, emerging treatment era primary MS (PPMS), more important than ever. Objectives: To test association cerebrospinal fluid (CSF) and serum markers PPMS patients; including fibrillary acidic protein (GFAP), chitinase-3-like 1 (CHI3L1), soluble variant triggering receptor expressed on myeloid cells 2 (sTREM2),...
// Frederic Sampedro 1, 2, 3, * , Eduard Vilaplana Mony J de Leon 4 Daniel Alcolea 2 Jordi Pegueroles Victor Montal María Carmona-Iragui Isabel Sala María-Belén Sánchez-Saudinos Sofía Antón-Aguirre Estrella Morenas-Rodríguez Valle Camacho 3 Carles Falcón 5, 7 Javier Pavía 6, Domènec Ros Clarimón Rafael Blesa Alberto Lleó Juan Fortea for the Alzheimer’s Disease Neuroimaging Initiative ** 1 Memory Unit,...
The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). role of immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates longevity. We studied effect on seven longevity, using 53,627 patients, 3,516 long-lived individuals 149,290 study-matched controls. replicated association AD we found an dementia Lewy bodies (DLB) frontotemporal (FTD). did not find...
Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and prediction of progression several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature various In present study, we analyzed NfL 535 participants SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS),...
Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven the activation of microglia. Aβ pathology appear to spread along pathways highly connected brain regions, it remains elusive whether microglial follows similar distribution pattern. Here, we assess connectivity associated with microglia patterns. Methods We included 32 Aβ‐positive early AD subjects...
Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation Alzheimer’s disease (AD) research. Sex obesity effects on TSPO-PET binding have been reported cognitively normal humans (CN), but such not yet systematically evaluated patients with AD. Thus, we aimed to investigate the impact sex relationship between β-amyloid-accumulation microglial activation Methods 49 AD (29 females, all...
Research Article27 November 2018Open Access Transparent process CSF progranulin increases in the course of Alzheimer's disease and is associated with sTREM2, neurodegeneration cognitive decline Marc Suárez-Calvet Corresponding Author [email protected] orcid.org/0000-0002-2993-569X Chair Metabolic Biochemistry, Biomedical Center (BMC), Faculty Medicine, Ludwig-Maximilians-Universität München, Munich, Germany German for Neurodegenerative Diseases (DZNE) Search more papers by this author Anja...
Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological neuropsychological evaluations, undergo structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18...
Abstract Dementia with Lewy Bodies (DLB) is a common neurodegenerative disorder poor prognosis and mainly unknown pathophysiology. Heritability estimates exceed 30% but few genetic risk variants have been identified. Here we investigated associated DLB in large European multisite sample. We performed genome wide association study Norwegian cohorts of 720 cases 6490 controls included 19 top-associated single-nucleotide polymorphisms an additional cohort 108 75545 from Iceland. Overall the 828...
Abstract Introduction We aimed to investigate if cerebral amyloid angiopathy (CAA) is more frequent in genetically determined than sporadic early‐onset forms of Alzheimer's disease (AD) (early‐onset AD [EOAD]). Methods Neuroimaging features CAA, apolipoprotein ( APOE ), and cerebrospinal fluid β (Aβ) 40 levels were studied subjects with Down syndrome (DS, n = 117), autosomal‐dominant (ADAD, 29), EOAD 42), healthy controls 68). Results CAA was present 31%, 38%, 12% cognitively impaired DS,...
Abstract Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 Triggering receptor expressed on myeloid cells 2) a microglial transmembrane protein brain that plays central role in microglia activation response to AD pathologies. Whether higher TREM2-related activity modulates develop clinical an open question. Thus, aim of current study was assess whether sTREM2 attenuates effects ApoE4-effects future...
<h3>Importance</h3> Allelic variation in the brain-derived neurotrophic factor (<i>BDNF</i>) Val66Met polymorphism moderates increases cerebrospinal fluid (CSF) levels of tau and phosphorylated 181 (p-tau181), measured using immunoassay, cognitive decline presymptomatic dominantly inherited Alzheimer disease (DIAD). Advances mass spectrometry show that CSF phosphorylation occupancy at threonine 217 (p-tau181/tau181, p-tau217/tau217) with initial β-amyloid (Aβ) aggregation, while 205...