A5063368037- Neuroinflammation and Neurodegeneration Mechanisms
- Inflammation biomarkers and pathways
- Neurological Disease Mechanisms and Treatments
- Multiple Sclerosis Research Studies
- Immune cells in cancer
- Immunotherapy and Immune Responses
- Immune Response and Inflammation
- HIV Research and Treatment
- Cytokine Signaling Pathways and Interactions
- Chemokine receptors and signaling
- Dietary Effects on Health
- Congenital heart defects research
- Psoriasis: Treatment and Pathogenesis
- RNA Research and Splicing
- Gut microbiota and health
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Dermatology and Skin Diseases
- IL-33, ST2, and ILC Pathways
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- CAR-T cell therapy research
- Atherosclerosis and Cardiovascular Diseases
- Cancer-related molecular mechanisms research
Washington University in St. Louis
2016-2023
University of Brescia
2014-2015
Abstract Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for clearance myelin debris in areas demyelination, a key step to allow remyelination. TREM2 expressed microglia promotes microglial survival, proliferation, phagocytic activity. Herein we demonstrate that was highly on myelin-laden phagocytes active demyelinating lesions CNS subjects with MS. In gene...
Common variants in the microglia-specific MS4A gene cluster modify risk for late-onset Alzheimer’s disease and modulate extracellular soluble TREM2.
B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized as important contributors progressive disease. This demyelination is notable for a 'surface-in' gradient neuronal loss and microglial activation, potentially reflecting the effects soluble factors secreted into CSF. We previously demonstrated that MS B-cell products are toxic oligodendrocytes neurons. The potential...
Background: Dimethyl fumarate (DMF) is used to treat relapsing multiple sclerosis and causes lymphopenia in a subpopulation of treated individuals. Much remains be learned about how the drug affects B- T-lymphocytes. Objectives: To characterize changes T-cell phenotype function induced by DMF investigate whether low absolute lymphocyte count (ALC) associated with unique functional changes. Methods: Peripheral blood mononuclear cells (PBMCs) were collected from DMF-treated patients, untreated...
Background: Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune demyelinating disease. Its pathogenesis involves humoral and cellular immunity, with production of pro- anti-inflammatory cytokines by T cells. Objective: To analyze the cytokine profile cerebrospinal fluid (CSF) cells in patients relapsing-remitting MS (RRMS) non-inflammatory controls. Methods: cell was analyzed flow cytometry CSF samples collected from 34 untreated RRMS 20 age-matched Immunofluorescence...
Monocyte inflammatory processes are fundamental events in AIDS pathogenesis. HIV-1 matrix protein p17, released from infected cells, was found to exert an interleukin (IL)-8 chemokine-like activity on human monocytes, promoting their trafficking and sustaining processes, after binding CXCR1. A haplotype of the CXCR1 gene (CXCR1_300_142) has been associated with slow HIV disease progression. Here, we determine how genetic variations impact p17 biological activity.Our results show that Jurkat...
The aim of this study is to shed light on the functional role slc7a6os, a gene highly conserved in vertebrates. Danio rerio slc7a6os encodes protein 326 amino acids with 46% identity human SLC7A6OS and 14% Saccharomyces cerevisiae polypeptide Iwr1. Yeast Iwr1 specifically binds RNA pol II, interacts basal transcription machinery regulates specific genes. In we investigated for first time biological Zebrafish maternal that expressed throughout development, prevalent localization developing...
Abstract Soluble triggering receptor expressed on myeloid cells 2 (sTREM2) levels in the cerebrospinal fluid (CSF) have been associated with Alzheimer disease (AD) status. TREM2 plays a critical role microglial activation, survival, and phagocytosis; however, pathophysiological of sTREM2 AD is not well understood. Understanding may help reveal biological mechanisms underlying identify novel therapeutic targets. We performed genome-wide association study (GWAS) to genetic modifiers CSF...
Abstract Background Variants within the gene‐rich membrane‐spanning 4‐domains subfamily A ( MS4A ) gene region have been associated with increased or reduced risk for Alzheimer's disease (AD) by large genome‐wide association studies (GWAS). Although family members are known to be cell membrane proteins implicated in immunity, their role AD pathogenesis has remained elusive. Another transmembrane protein a key immunity is triggering receptor expressed on myeloid cells 2 (TREM2) and low...
Background: B cells can be enriched within meningeal immune-cell aggregates of multiple sclerosis (MS) patients, adjacent to subpial cortical demyelinating lesions now recognized as important contributors progressive disease. This demyelination is notable for a ‘surface-in’ gradient neuronal loss and microglial activation, potentially reflecting the effects soluble factors secreted into CSF. We previously demonstrated that MS B-cell products are toxic oligodendrocytes neurons. Their...
To examine possible mechanisms for DMF-induced lymphopenia and investigate whether absolute lymphocyte count (ALC) affects T-cell function among DMF-treated patients.
May 6, 2019April 9, 2019Free AccessCross-talk between Multiple Sclerosis (MS)-relevant B cell subsets and myeloid cells: potential contribution to the CNS-compartmentalized inflammation associated with disease progression (P2.2-083)Hanane Touil, Rui Li, Leah Zuroff, Craig Moore, Luke M. Healy, Francesca Cignarella, Laura Piccio, Samuel Ludwin, Jennifer Gommerman, Alexandre Prat, Jack Antel, Amit Bar-OrAuthors Info & AffiliationsApril 2019 issue92...