A5083335317- Gut microbiota and health
- Ginseng Biological Effects and Applications
- Neurological Disease Mechanisms and Treatments
- Inflammation biomarkers and pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Mycobacterium research and diagnosis
- Tryptophan and brain disorders
- Cancer survivorship and care
Washington University in St. Louis
2020-2022
Abstract Multiple sclerosis (MS) is an inflammatory, demyelinating, and neurodegenerative disease of the central nervous system (CNS) triggered by autoimmune mechanisms. Microglia are critical for clearance myelin debris in areas demyelination, a key step to allow remyelination. TREM2 expressed microglia promotes microglial survival, proliferation, phagocytic activity. Herein we demonstrate that was highly on myelin-laden phagocytes active demyelinating lesions CNS subjects with MS. In gene...
Multiple sclerosis (MS) has a complex genetic, immune and metabolic pathophysiology. Recent studies implicated the gut microbiome in MS pathogenesis. However, interactions between host system, metabolism diet have not been studied over time this disorder.We performed six-month longitudinal multi-omics study of 49 participants (24 untreated relapse remitting patients 25 age, sex, race matched healthy control individuals. Gut composition function were characterized using 16S metagenomic...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied.In this case-control observational study, we performed ITS sequencing characterised people with (pwMS) healthy controls at baseline after six months.The had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied. We performed ITS sequencing characterized people with (pwMS) healthy controls at baseline after six months. had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively regulatory B cells, while activated CD16+...