A5084623666- Gut microbiota and health
- Peripheral Neuropathies and Disorders
- Myasthenia Gravis and Thymoma
- Tryptophan and brain disorders
- Ginseng Biological Effects and Applications
- GABA and Rice Research
- Hemoglobinopathies and Related Disorders
- Mycobacterium research and diagnosis
- Pharmacological Effects of Medicinal Plants
- Clostridium difficile and Clostridium perfringens research
- Parkinson's Disease and Spinal Disorders
- Cancer survivorship and care
- COVID-19 Impact on Reproduction
- Antifungal resistance and susceptibility
- Bone and Joint Diseases
- Gestational Diabetes Research and Management
- Birth, Development, and Health
- Inflammatory Bowel Disease
- RNA modifications and cancer
- Gastrointestinal motility and disorders
- Bariatric Surgery and Outcomes
- Metabolism, Diabetes, and Cancer
- Bacteriophages and microbial interactions
- Dermatology and Skin Diseases
UConn Health
2021-2024
National Institute of Mental Health and Neurosciences
2016-2018
Multiple sclerosis (MS) has a complex genetic, immune and metabolic pathophysiology. Recent studies implicated the gut microbiome in MS pathogenesis. However, interactions between host system, metabolism diet have not been studied over time this disorder.We performed six-month longitudinal multi-omics study of 49 participants (24 untreated relapse remitting patients 25 age, sex, race matched healthy control individuals. Gut composition function were characterized using 16S metagenomic...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied.In this case-control observational study, we performed ITS sequencing characterised people with (pwMS) healthy controls at baseline after six months.The had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively...
The powerful immune responses elicited by the mRNA vaccines targeting SARS-CoV-2 Spike protein contribute to their high efficacy. Yet, efficacy can vary greatly between individuals. For not based on mRNA, cumulative evidence suggests that differences in composition of gut microbiome, which impact vaccine immunogenicity, are some factors variations However, it is unclear if microbiome impacts novel mode immunogenicity vaccines. We conducted a prospective longitudinal cohort study individuals...
Abstract Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. The development of novel therapeutic preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between gut microbiome microbial metabolites with behavior, but druggable targets their underlying mechanism action understudied. Results Here, using a drink-in-the-dark mouse model, we...
Boswellia serrata, commonly known as frankincense, has been used for centuries a natural anti-inflammatory and anti-microbial remedy many illnesses. However, the effect of bioactive ingredient it, 3-O-acetyl-11-keto-b-boswellic acid (AKBA), on both gut microbiome blood metabolites, is not known. In this study, we observe isolated active orally male female mice. Gut microbiota metabolites were determined at beginning end 14-day consumption period. AKBA significantly decreased bacterial...
Abstract Bone loss is common in sickle cell disease (SCD), but the molecular mechanisms unclear. Serum insulin-like growth factor 1 (IGF1) was low SCD subjects and mice. To determine if decreased IGF1 associated with bone mass due to reduced SCFA production by gut microbiota, we performed reciprocal fecal microbiota transplantation (FMT) between healthy control (Ctrl) uCT histomorphometry analysis of femur showed volume/total volume (BV/TV), trabecular number (Tb.N), osteoblast surface/bone...
Gestational diabetes mellitus (GDM) represents a significant health concern during pregnancy, impacting both maternal and fetal well-being. While conventional diagnostic protocols typically rely on blood glucose levels in the latter stages of there is pressing need for early detection methods to mitigate potential risks. A plethora glucose-based or non-glucose-based biomarkers have been investigated their predict GDM pregnancy. Though specific showed promise predicting GDM, clinical usage...
<title>Abstract</title> Background Despite serious health and social consequences, effective intervention strategies for habitual alcohol binge drinking are lacking. Development of novel therapeutic preventative approaches is highly desirable. Accumulating evidence in the past several years has established associations between gut microbiome microbial metabolites with behavior, but druggable targets their underlying mechanism action understudied. Results Here, using a drink-in-the-dark mouse...
To assess the practicality of dot-blot testing for rapid and sensitive detection antiacetylcholine receptor (anti-AChR) antibodies in myasthenia gravis (MG).In this case-control study, we tested serum specimens 85 patients with MG, healthy control individuals, without MG who have other autoimmune neurological illnesses. All were anti-AChR using 3 assays: in-house enzyme-linked immunosorbent assay (ELISA), assay, commercial ELISA.In-house ELISA, test results positive 65 (76.5%) MG. The all...
Objective: To evaluate transcervical and transsternal thymectomy benefits in large myasthenia gravis (MG) cohort.Method: We retrospectively evaluated MG patients (n = 184) who had undergone between 2004 2015 at National Institute of Mental Health Neurosciences, Bangalore (India). Myasthenia foundation America guidelines were followed to assess clinical outcome. Anti-acetylcholine receptors (AChR) antibodies, repetitive nerve stimulation (RNS) Neostigmine tests performed pre post-thymectomy...
Asthma is associated with significant morbidity. The gut microbiome has been shown to effect asthma development and exacerbation. In this study, we tested an oral supplement containing Boswellia serrata (Indian frankincense) tree resin on allergic pulmonary inflammation microbiome. An OVA based airway model was used mice were orally gavaged 100 mg/kg of as a supplementation throughout sensitization challenge. Treated showed weight loss, lower total lung leukocytes, eosinophil Th2 cytokines,...
Abstract Multiple sclerosis (MS) is an autoimmune condition associated with dysbiosis in the bacterial element of microbiome, yet limited information exists regarding virome. In this study, we examined virome 20 relapsing-remitting MS (RRMS) patients and 22 healthy controls (HC). We extracted virus-like particles (VLP) genomic DNA through sequential filtration, followed by deep metagenomic sequencing approaches without multiple displacement amplification (MDA). found significantly lower...
Abstract Bone loss is common in sickle cell disease (SCD), but the molecular mechanisms unclear. Serum insulin-like growth factor 1 (IGF1) was low SCD subjects and mice. To determine if decreased IGF1 associated with bone mass due to reduced SCFA production by gut microbiota, we performed reciprocal fecal microbiota transplantation (FMT) between healthy control (Ctrl) uCT histomorphometry analysis of femur showed volume/total volume (BV/TV), trabecular number (Tb.N), osteoblast surface/bone...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied. We performed ITS sequencing characterized people with (pwMS) healthy controls at baseline after six months. had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively regulatory B cells, while activated CD16+...