A5064218221- Immunotherapy and Immune Responses
- Gut microbiota and health
- Ginseng Biological Effects and Applications
- T-cell and B-cell Immunology
- Multiple Sclerosis Research Studies
- Asthma and respiratory diseases
- Mycobacterium research and diagnosis
- Cardiovascular Issues in Pregnancy
- Neuropeptides and Animal Physiology
- Gestational Trophoblastic Disease Studies
- Cancer survivorship and care
- Pregnancy and Medication Impact
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
- Peroxisome Proliferator-Activated Receptors
- Tryptophan and brain disorders
- Ion channel regulation and function
- NF-κB Signaling Pathways
- CAR-T cell therapy research
- Extracellular vesicles in disease
- Monoclonal and Polyclonal Antibodies Research
- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
The Ohio State University
2011-2022
The Ohio State University Wexner Medical Center
2013-2021
Thomas Jefferson University
2013
Rockefeller University
2013
University of Rochester
2013
University of Pennsylvania
2013
Cornell University
2013
Multiple sclerosis (MS) has a complex genetic, immune and metabolic pathophysiology. Recent studies implicated the gut microbiome in MS pathogenesis. However, interactions between host system, metabolism diet have not been studied over time this disorder.We performed six-month longitudinal multi-omics study of 49 participants (24 untreated relapse remitting patients 25 age, sex, race matched healthy control individuals. Gut composition function were characterized using 16S metagenomic...
Acid-sensing ion channel (ASIC) subunits associate to form homomeric or heteromeric proton-gated channels in neurons throughout the nervous system. The ASIC1a subunit plays an important role establishing kinetics of currents CNS, and activation induces neuronal death after local acidosis that accompanies cerebral ischemia. ASIC2b is expressed brain a pattern overlaps ASIC1a, yet contribution has remained elusive. We find coexpression with <i>Xenopus</i> oocytes results novel properties...
Background: Ublituximab, a novel monoclonal antibody (mAb) targeting unique epitope on the CD20 antigen, is glycoengineered for enhanced B-cell through antibody-dependent cellular cytotoxicity (ADCC). Greater ADCC may allow lower doses and shorter infusion times versus other anti-CD20 mAbs. Objective: The objective was to determine optimal dose, time, activity of ublituximab in relapsing multiple sclerosis. Methods: This phase 2, placebo-controlled study. Patients received three infusions...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied.In this case-control observational study, we performed ITS sequencing characterised people with (pwMS) healthy controls at baseline after six months.The had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively...
Transforming growth factor beta (TGFβ) signalling is critical for regulatory T cell development and function, dysregulation a common observation in autoimmune diseases, including multiple sclerosis. In comprehensive miRNA profiling study of patients with sclerosis naïve CD4 cells, 19 differentially expressed miRNAs predicted to target the TGFβ pathway were identified, leading hypothesis that may be responsible defect observed Patients had reduced levels components their cells. The negatively...
Multiple sclerosis (MS) is a demyelinating disease of the central nervous system, thought to be mediated by myelin-specific CD4+ T cells. However, B cell depletion has proven an effective therapy for MS, but mechanism not well understood. This study was designed determine how changes lymphocyte profiles. During phase IIa clinical trial with ublituximab, novel CD20 antibody, blood collected from 48 MS patients at 11 time points over 24 weeks and profiles were analyzed flow cytometry. The...
Soluble CD23 plays a role in the positive regulation of an IgE response. Engagement β2 adrenergic receptor (β2AR) on B cell is known to enhance level both soluble and IgE, although mechanism by which this occurs not completely understood. In study, we report that, comparison with CD40 ligand/IL-4-primed murine alone, β2AR engagement primed increased gene expression disintegrin metalloproteinase (ADAM)10, primary sheddase CD23, as well protein ADAM10, kinase A- p38 MAPK-dependent manner,...
B cell depletion therapy has been shown to be beneficial in multiple sclerosis (MS). However, the mechanism by which mediates its effects MS is still unclear. To better understand how may benefit patients with a disease previously thought primarily mediated CD4 T cells, immune profiles were monitored 48 phase II trial of ublituximab, glycoengineered CD20 monoclonal antibody, at 18 time points over year. As we described there was significant shift percentages NK and myeloid cells following...
Abstract Peroxisome proliferator-activated receptorg (Pparγ) is a member of the nuclear receptor (NR) superfamily, which regulates diverse biological functions including lipogenesis and differentiation, anti-inflammation, insulin sensitivity, cellular proliferation, autophagy. Independent lines evidence support role for Pparγ as either collaborative oncogene or tumor suppressor. Heterozygous mutations have been detected in 4/55 patients with colon cancer chromosomal translocation between...
The mycobiome is the fungal component of gut microbiome and implicated in several autoimmune diseases. However, its role MS has not been studied. We performed ITS sequencing characterized people with (pwMS) healthy controls at baseline after six months. had significantly higher alpha diversity inter-subject variation pwMS than controls. Saccharomyces Aspergillus were over-represented pwMS. was positively correlated circulating basophils negatively regulatory B cells, while activated CD16+...