A5065534638- Alzheimer's disease research and treatments
- Dementia and Cognitive Impairment Research
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Trace Elements in Health
- Erythropoietin and Anemia Treatment
- Parkinson's Disease Mechanisms and Treatments
- Amyotrophic Lateral Sclerosis Research
- Health, Environment, Cognitive Aging
- Erythrocyte Function and Pathophysiology
- S100 Proteins and Annexins
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Neurological diseases and metabolism
- Prion Diseases and Protein Misfolding
- Neonatal Health and Biochemistry
- Porphyrin Metabolism and Disorders
- Metabolomics and Mass Spectrometry Studies
- Diet and metabolism studies
- Schizophrenia research and treatment
- Neurogenetic and Muscular Disorders Research
- Restless Legs Syndrome Research
- Cerebrospinal fluid and hydrocephalus
- Biomarkers in Disease Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
Hospital de Sant Pau
2013-2025
Universitat Autònoma de Barcelona
2013-2025
Université de Montpellier
2016-2025
Inserm
2015-2025
Institute for Neurosciences of Montpellier
2013-2024
Hôpital Saint Eloi
2013-2024
Institute for Regenerative Medicine & Biotherapy
2014-2024
Centre Hospitalier Universitaire de Montpellier
2013-2024
Centre de Biologie Structurale
2023
Biomedical Research Institute
2023
The cerebrospinal fluid (CSF) biomarkers amyloid-β (Aβ), tau and phosphorylated (p-tau181) are now used for the diagnosis of Alzheimer's disease (AD). Aβ40 is most abundant Aβ peptide isoform in CSF, 42/40 ratio has been proposed to better reflect brain amyloid production. However, its additional value clinical setting remains uncertain.A total 367 subjects with cognitive disorders who underwent a lumbar puncture were prospectively included at three French memory centers (Paris-North, Lille...
Abstract Background Acute intermittent porphyria ( AIP ) is an inherited disorder of haem metabolism characterized by life‐threatening acute neurovisceral attacks due to the induction hepatic δ‐aminolevulinic acid synthase 1 ALAS 1) associated with hydroxymethylbilane HMBS deficiency. So far, treatment choice hemin which represses 1. The main issue in medical care patients occurrence debilitating recurrent attacks. Objective aim this study was determine whether chronic administration...
Cerebrospinal fluid (CSF) biomarkers are useful in the diagnosis and prediction of progression several neurodegenerative diseases. Among them, CSF neurofilament light (NfL) protein has particular interest, as its levels reflect neuroaxonal degeneration, a common feature various In present study, we analyzed NfL 535 participants SPIN (Sant Pau Initiative on Neurodegeneration) cohort including cognitively normal participants, patients with Alzheimer disease (AD), Down syndrome (DS),...
Objectives Plasma P-tau181 is an increasingly established diagnostic marker for Alzheimer’s disease (AD). Further validation in prospective cohorts still needed, as well the study of confounding factors that could influence its blood level. Methods This ancillary to multicentre Biomarker AmyLoid pepTide and AlZheimer’s diseAse Risk cohort enrolled participants with mild cognitive impairment (MCI) who were examined conversion dementia up 3 years. Ptau-181 was measured using ultrasensitive...
Background Among plasma biomarkers for Alzheimer’s disease (AD), pTau181 and pTau217 are the most promising. However, transition from research to routine clinical use will require confirmation of performance in prospective cohorts evaluation cofounding factors. Method were quantified using, Quanterix ALZpath, SIMOA assays well-characterised multicentre BALTAZAR (Biomarker AmyLoid pepTide AlZheimer's diseAse Risk) cohort participants with mild cognitive impairment (MCI). Results MCI, 55% Aβ+...
Selecting the most appropriate blood tests is crucial for management of patients with amyotrophic lateral sclerosis (ALS). This study evaluates diagnostic and prognostic performance neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), phosphorylated tau 181 (pTau181) biomarkers in ALS to establish their clinical relevance cutoff values. In a cohort from center Montpellier, we conducted head-to-head comparison 4 different technologies 3 distinct serum analytes: NfL was...
Tissue macrophages play an essential role in iron recycling through the phagocytosis of senescent RBCs (red blood cells). Following haem catabolism by HO1 (haem oxygenase 1), they recycle back into plasma exporter Fpn (ferroportin). We previously described a cellular model EP (erythrophagocytosis), based on primary cultures mouse BMDMs (bone-marrow-derived macrophages) and aged murine RBCs, showed that induces changes expression profiles HO1. In present paper, we demonstrate derived from...
Intestinal epithelial cells and reticuloendothelial macrophages are, respectively, involved in diet iron absorption heme recycling from senescent erythrocytes, two critical processes of homeostasis. These appear to use the same transporter, ferroportin (Slc40a1), export iron. The aim this study was compare localization, expression, regulation both duodenal macrophage cells. Using a high-affinity purified polyclonal antibody, we analyzed localization expression protein spleen, liver, duodenum...
Background: Cerebrospinal fluid (CSF) biomarkers Aβ peptides and tau proteins improved the diagnosis of Alzheimer's disease (AD) in research, clinical settings. We previously described PLM-scale (Paris-Lille-Montpellier study) which combines Aβ42, phosphorylated ptau(181) an easy to use clinically relevant way. The purpose this work is evaluate interest optimized PLMR-scale (PLM ratio scale) that now includes Aβ42/Aβ40 detect AD versus non-AD (NAD) participants routine memory centers....
Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological neuropsychological evaluations, undergo structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18...
Abstract Background Amyloid pathology, which is one of the characteristics Alzheimer’s disease (AD), results from altered metabolism beta-amyloid (Aβ) peptide in terms synthesis, clearance, or aggregation. A decrease cerebrospinal fluid (CSF) level Aβ1–42 evident AD, and CSF ratio Aβ42/Aβ40 has recently been identified as most reliable diagnostic biomarkers amyloid pathology. Variations inter-individual levels Aβ1–40 have observed past, but their origins remain unclear. In addition,...
Objectives All categories included in the AT(N) classification can now be measured plasma. However, their agreement with cerebrospinal fluid (CSF) markers is not fully established. A blood signature to generate would facilitate early diagnosis of patients Alzheimer’s disease (AD) through an easy and minimally invasive approach. Methods We Aβ, pTau181 neurofilament light (NfL) 150 plasma samples Sant Pau Initiative on Neurodegeneration cohort including mild cognitive impairment, AD dementia,...
Abstract Introduction The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting results may differ, which can lead misunderstandings raises questions about commutability tests. Methods We obtained description (pre‐)analytical protocols sample reports 40 centers worldwide. A consensus approach allowed us propose harmonized comments...
Cerebrospinal fluid (CSF) Aβ1-42 levels and the Aβ1-42/Aβ1-40 ratio are markers of amyloid pathology, but previous studies suggest that their might be influenced by additional pathophysiological processes.
Background Senescent red blood cells (RBC) are recognized, phagocytosed and cleared by tissue macrophages. During this erythrophagocytosis (EP), RBC engulfed processed in special compartments called erythrophagosomes. We previously described that following EP, heme is rapidly degraded through the catabolic activity of oxygenase (HO). Extracted iron then either exported or stored However, cellular localization early steps processing extraction during EP remains to be clearly defined....
The objective of this study was to analyze differences in biomarker outcomes before and after harmonization cerebrospinal fluid (CSF) collection tubes Alzheimer's disease (AD) diagnosis.We analyzed data from French memory centers that switched different CSF a common one. A total 1966 patients were included the study. concentrations β-amyloid 1-42 (Aβ42), tau, phosphorylated tau (p-tau181) measured each center using same commercial enzyme-linked immunoabsorbent assay (ELISA) kits. diagnostic...