A5039735259- Alzheimer's disease research and treatments
- COVID-19 Clinical Research Studies
- Dementia and Cognitive Impairment Research
- Long-Term Effects of COVID-19
- Medical Imaging Techniques and Applications
- Supramolecular Self-Assembly in Materials
- Lipid Membrane Structure and Behavior
- Health, Environment, Cognitive Aging
- Cholesterol and Lipid Metabolism
- Frailty in Older Adults
- RNA Interference and Gene Delivery
- COVID-19 and healthcare impacts
- Sphingolipid Metabolism and Signaling
- Peroxisome Proliferator-Activated Receptors
- Diabetes and associated disorders
- Curcumin's Biomedical Applications
- SARS-CoV-2 and COVID-19 Research
- Cholinesterase and Neurodegenerative Diseases
- Vitamin C and Antioxidants Research
- Radiomics and Machine Learning in Medical Imaging
- Zebrafish Biomedical Research Applications
- Multiple Sclerosis Research Studies
- Regulation of Appetite and Obesity
- Methodologies in Health Research and Practice
- Neuroinflammation and Neurodegeneration Mechanisms
Université de Lorraine
2019-2025
Laboratoire Animal et Agroécosystèmes
2019-2024
Inserm
2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2021-2024
Nia Association
2022
ID Genomics (United States)
2022
Laboratoire de Chimie Physique et Microbiologie pour l'Environnement
2021
Centre Hospitalier Régional et Universitaire de Nancy
2018-2019
Abstract Background In patients with severe coronavirus disease 2019 (COVID-19), data are scarce and conflicting regarding whether chronic use of angiotensin-converting enzyme inhibitor (ACEI) or angiotensin receptor blocker (ARB) influences outcomes. COVID-19, we assessed the association between ACEI/ARB occurrence kidney, lung, heart, liver dysfunctions severity inflammatory reaction as evaluated by biomarkers kinetics, their Methods We performed a retrospective longitudinal cohort study...
Abstract Introduction The current practice of quantifying cerebrospinal fluid (CSF) biomarkers as an aid in the diagnosis Alzheimer's disease (AD) varies from center to center. For a same biochemical profile, interpretation and reporting results may differ, which can lead misunderstandings raises questions about commutability tests. Methods We obtained description (pre‐)analytical protocols sample reports 40 centers worldwide. A consensus approach allowed us propose harmonized comments...
Reports have highlighted thyroid abnormalities, including subacute thyroiditis and thyrotoxicosis, in COVID-19 patients, with a potential link between dysfunction disease severity. However, population-level studies on COVID-19's impact hormone levels are limited. We aimed to assess the of pandemic function tests at population level. conducted repeated cross-sectional study consecutive patients who underwent March 1 April 15, 2020, during first wave northeastern France, compared results those...
Precisely defining the delay in onset of dementia is a particular challenge for early diagnosis. Brain [
Deciphering the mechanism of Alzheimer's disease is a key element for designing an efficient therapeutic strategy. Molecular dynamics (MD) calculations, atomic force microscopy, and infrared spectroscopy were combined to investigate β-amyloid (Aβ1-42) peptide interactions with supported lipid bilayers (SLBs). The MD simulations showed that nascent Aβ1-42 monomers remain anchored within model phospholipid bilayer's hydrophobic core, which suggests their stability in native environment. We...
Lipids play multiple roles in preserving neuronal function and synaptic plasticity, polyunsaturated fatty acids (PUFAs) have been of particular interest optimizing membrane organization function. We developed a green-based methodology to prepare nanoliposomes (NL) from lecithin that was extracted fish head by-products. These NL range between 100-120 nm diameter, with an n-3/n-6 acid ratio 8.88. The high content n-3 PUFA (46.3% total content) docosahexanoic (26%) these represented means for...
The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be involved in viral infections, including COVID-19. We here aim to decipher whether plasma concentration of soluble form (sTREM-1) predict outcome hospitalized COVID-19 patients.We conducted a multicentre prospective observational study 3 university hospitals France. Consecutive patients...
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but use in biological applications hindered by sensitivity to light, oxygen, temperature. Furthermore, due low water solubility, curcumin has a poor pharmacokinetic profile bioavailability. In this study, we evaluated the potential application of as neuroprotective agent encapsulated RGD peptide-PEGylated nanoliposomes developed from salmon-derived lecithin. Salmon lecithin, rich polyunsaturated fatty...
Self-aggregation of Curcumin (Cur) in aqueous biological environment decreases its bioavailability and vivo therapeutic efficacy, which hampers clinical use as candidate for reducing risk neurodegenerative diseases. Here, we focused on the design new Cur- β-Cyclodextrin nanoconjugates to improve solubility reduce cell toxicity Cur. In this study, described synthesis, structural characterization, photophysical properties neuron two water soluble β-CD/Cur strategy risks Cur was coupled one or...
The regulation of cholesterol, an essential brain lipid, ensures proper neuronal development and function, as demonstrated by links between perturbations cholesterol metabolism neurodegenerative diseases, including Alzheimer's disease. central nervous system (CNS) acquires via de novo synthesis, where glial cells provide to neurons. Both lipoproteins lipoprotein receptors are key elements in this intercellular transport, the latter recognize, bind endocytose containing glia-produced...
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) play an important role in the development, maintenance, and function of brain. Dietary supplementation n-3 PUFAs neurological diseases has been a subject particular interest preventing cognitive deficits, particularly age-related neurodegeneration. Developing strategies for efficient delivery these lipids to brain presented challenge recent years. We recently reported preparation PUFA-rich nanoliposomes (NLs) from salmon lecithin, demonstrated...
Abstract Background The quantification of cerebrospinal fluid (CSF) biomarkers (Amyloid beta peptides [Aß1‐40 and Aß1‐42], t‐tau p‐tau(181)) is progressively implemented in specialized laboratories as an aid for the multidisciplinary diagnosis Alzheimer’s disease (AD). There however a diversity practices between centers related to pre‐analytical analytical conditions, calculation ratios analytes, applied cut‐off, or use interpretation scales. Finally, same biochemical profile, reporting...
Perturbations of cholesterol metabolism have been linked to neurodegenerative diseases. Glia-neuron crosstalk is essential achieve a tight regulation brain trafficking. Adequate supply from glia via apolipoprotein E-containing lipoproteins ensures neuronal development and function. The lipolysis-stimulated lipoprotein receptor (LSR), plays an important role in homeostasis. Aged heterozygote Lsr+/- mice show altered distribution increased susceptibility amyloid stress. Since LSR expression...
Soft nanoparticles, and in particular, nanoliposomes (NL), have attracted increasing interest for their use food, nutraceuticals, pharmaceutics drug delivery. Recent data using salmon lecithin NL suggest that these NL, rich omega-3 (n-3) fatty acids, can improve the bioavailability transport of molecules through blood brain barrier (BBB) to target prevention treatment neurodegenerative diseases. The objective this study was characterize physicochemical properties analyze transfer phenomena...
Abstract Purpose Digital PET cameras markedly improve sensitivity and spatial resolution of brain 18 F-FDG images compared to conventional cameras. Our study aimed assess whether specific control databases are required the diagnostic performance these recent advances. Methods We retrospectively selected two groups subjects, twenty-seven Alzheimer's Disease (AD) patients twenty-two healthy (HC) subjects. All subjects underwent a on digital camera (Vereos, Philips®). These group (AD HC)...
Abstract CRE recombinase is a protein that recognizes and mediates site-specific recombination between loxP site sequences. The Cre/loxP system has become useful tool for genetic manipulation. Spatial regulation of can be achieved by using cell type-specific promoters drive expression in the tissue interest. temporal obtained with CreER recombinase, which consists Cre fused to mutated hormone-binding domain estrogen receptor (ER). In more improved versions construct, - mediated gene...
Docosahexaenoic acid (DHA, C22:6 ω3) may be involved in various neuroprotective mechanisms that could prevent Alzheimer's disease (AD). Its influence has still been little explored regarding the dysfunction of endolysosomal pathway, known as an early key event physiopathological continuum triggering AD. This result from accumulation degradation products precursor protein AD, particular C99 fragment, capable interacting with endosomal proteins and thus contributing to altering this pathway...