A5068586945- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Angiogenesis and VEGF in Cancer
- Photoacoustic and Ultrasonic Imaging
- Cancer, Hypoxia, and Metabolism
- Click Chemistry and Applications
- Nanoparticle-Based Drug Delivery
- Photochromic and Fluorescence Chemistry
- Intraperitoneal and Appendiceal Malignancies
- Electrospun Nanofibers in Biomedical Applications
- Advanced Photocatalysis Techniques
- Surfactants and Colloidal Systems
- biodegradable polymer synthesis and properties
- Photochemistry and Electron Transfer Studies
- Bone Tissue Engineering Materials
- Luminescence Properties of Advanced Materials
- Supramolecular Self-Assembly in Materials
- Luminescence and Fluorescent Materials
- Organic Chemistry Cycloaddition Reactions
- Ovarian cancer diagnosis and treatment
- Metal complexes synthesis and properties
- Advanced Nanomaterials in Catalysis
- Cancer Treatment and Pharmacology
- Antioxidant Activity and Oxidative Stress
Université de Lorraine
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Laboratoire Réactions et Génie des Procédés
2015-2024
Centre de Recherche en Automatique de Nancy
2010-2011
Laboratoire Sols et Environnement
1997-2011
CEA LETI
2010
Photometrics (United States)
2010
Laboratoire de Chimie Physique
1997-2010
Laboratoire de Chimie-Physique Macromoléculaire
2010
University of Bologna
2008
A rotaxane is described in which a macrocycle moves reversibly between two hydrogen-bonding stations after nanosecond laser pulse. Observation of transient changes the optical absorption spectrum photoexcitation allows direct quantitative monitoring submolecular translational process. The rate shuttling was determined and influence surrounding medium studied: At room temperature acetonitrile, photoinduced movement to second station takes about 1 microsecond and, charge recombination (about...
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of pendant porphyrin using NIR laser light, imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through mannose receptor-mediated endocytosis mechanism provide 3-fold enhancement PDT effect.
Tb2O3 coated with a polysiloxane layer is biocompatible nanoscintillator that exhibits an appropriate pattern of biodistribution after injection. In this contribution, we combine nanosystem porphyrin molecules are able to generate singlet oxygen, major cytotoxic agent for photodynamic therapy application. Using time-resolved laser spectroscopy and oxygen probes, demonstrate combination suitable generation induced by X-ray provide physical study the energy transfer observed between porphyrin....
In the present work, we report on synthesis of cellulose cotton fibers bearing different types photosensitizers with aim to prepare new efficient polymeric materials for antimicrobial applications. Anionic, neutral, and cationic amino porphyrins have been covalently grafted fabric, without previous chemical modification cellulosic support, using a 1,3,5-triazine derivative as linker. The obtained porphyrin-grafted fabrics were characterized by infrared (ATR-FTIR), diffuse reflectance UV−vis...
Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness PDT depends on light dosimetry, oxygen availability, and properties the photosensitizer (PS). Depending medium, photophysical PS can change leading to increase decrease in fluorescence emission formation reactive species (ROS) especially singlet (1O2). In this study, influence solvent polarity, viscosity, concentration, temperature, pH medium protoporphyrin IX, pyropheophorbide-a,...
Establishing methods for controlling aspects of large amplitude submolecular movements is a prerequisite the development artificial devices that function through rotary motion at molecular level. Here we demonstrate rate rotation interlocked components fumaramide-derived [2]rotaxanes can be accelerated, by >6 orders magnitude, isomerizing them to corresponding maleamide using light.
The cell membrane folate receptor (FR) is a molecular target for tumor-selective drug delivery, including delivery of photosensitizers anticancer photodynamic therapy (PDT). Tumor selectivity meta-tetra(hydroxyphenyl)chlorin (m-THPC), photosensitizer used in PDT clinical trials, demonstrates low tumor-to-normal epithelial uptake ratio. We report on the synthesis and photophysical properties m-THPC-like 1 conjugated to folic acid (compound 8). A comparative study accumulation 8 described....
We developed a novel technique involving knitting and electrospinning to fabricate composite scaffold for ligament tissue engineering. Knitted structures were coated with poly(L-lactic-co-e-caprolactone) (PLCL) then placed onto rotating cylinder PLCL solution was electrospun the structure. Highly aligned 2-microm-diameter microfibers covered space between stitches adhered knitted scaffolds. The stress-strain tensile curves exhibited an initial toe region similar behavior of ligaments....
A novel compound consisting of a cationic porphyrin covalently attached to derivative polymyxin B has been synthesized and presents enhanced activity targeting properties compared the usual porphyrins recognized as efficient photosensitizers in photodynamic antimicrobial chemotherapy (PACT). synthesis pathway was established preserve bactericidal peptide. Accordingly, N-terminal amino acid (l-2,4-diaminobutyric acid) (PMB) switched for cysteine residue. Then, resulting PMB bound...
Photodynamic therapy has become of interest in many European countries. Since, most national authorities and all medical journals require the registration clinical study on database ClinicalTrials. gov order to be published, information regarding studies are now available. This article aims synthetize data gathered thanks this database. The keywords used for analysis was: (i) status: “All “(recruiting, completed, terminated, we did not take into account unknown status), (ii) condition or...