A5065648876- Nanoplatforms for cancer theranostics
- Silicon Nanostructures and Photoluminescence
- Nanowire Synthesis and Applications
- Nanoparticle-Based Drug Delivery
- RNA Interference and Gene Delivery
- Immunotherapy and Immune Responses
- Advanced Nanomaterials in Catalysis
- Porphyrin and Phthalocyanine Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Chemical Synthesis and Analysis
- Enzyme Catalysis and Immobilization
- Pancreatic function and diabetes
- Polydiacetylene-based materials and applications
- Cancer Research and Treatment
- Carbohydrate Chemistry and Synthesis
- Mass Spectrometry Techniques and Applications
- Diet, Metabolism, and Disease
- Quantum Dots Synthesis And Properties
- Gold and Silver Nanoparticles Synthesis and Applications
- Glycosylation and Glycoproteins Research
- Nonlinear Optical Materials Studies
- Click Chemistry and Applications
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Photodynamic Therapy Research Studies
Scripps Research Institute
2021
Université de Montpellier
2016-2019
Centre National de la Recherche Scientifique
2014-2019
Institut des Biomolécules Max Mousseron
2013-2019
École Nationale Supérieure de Chimie de Montpellier
2019
Centre Occitanie-Montpellier
2016
Porous silicon nanoparticles (pSiNPs) act as a sensitizer for the 2-photon excitation of pendant porphyrin using NIR laser light, imaging and photodynamic therapy. Mannose-functionalized pSiNPs can be vectorized to MCF-7 human breast cancer cells through mannose receptor-mediated endocytosis mechanism provide 3-fold enhancement PDT effect.
Multifunctionalized porous silicon nanoparticles (pSiNPs), containing the novel Ru(ii) complex-photosensitizer, polyethylene glycol moiety, and mannose molecules as cancer targeting ligands, are constructed showcased for application in near infrared (NIR) light-responsive photodynamic therapy (PDT) imaging of cancer. Exposure to NIR light leads two-photon excitation Ru(ii)-complex which allows efficient simultaneous cancer-imaging targeted PDT with functionalized biodegradable pSiNP nanocarriers.
Abstract The development of personalized and non‐invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over‐expression membrane lectin, cation‐independent mannose 6‐phosphate receptor (M6PR), was specifically demonstrated prostate cell lines tissues. To efficiently target lectin mannose‐6‐phosphate analogue synthesized six steps grafted onto surface functionalized mesoporous silica nanoparticles (MSNs). These MSNs...
Porous silicon nanoparticles grafted with a mannose-6-phosphate analogue were designed for targeting prostate cancer cells.
The aim of the present work is development highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for photodynamic therapy (PDT) prostate cancer. We chose strategy develop a novel compound that allows improvement cation-independent mannose 6-phosphate receptor, which overexpressed in This original sugar, dimannoside-carboxylate (M6C-Man) grafted on surface MSN PDT applications, leads higher endocytosis and thus increases efficacy MSNs.
Abstract The development of personalized and non‐invasive cancer therapies based on new targets combined with nanodevices is a major challenge in nanomedicine. In this work, the over‐expression membrane lectin, cation‐independent mannose 6‐phosphate receptor (M6PR), was specifically demonstrated prostate cell lines tissues. To efficiently target lectin mannose‐6‐phosphate analogue synthesized six steps grafted onto surface functionalized mesoporous silica nanoparticles (MSNs). These MSNs...
Abstract In this work, we prepared porous silicon (pSi) nanostructures decorated with gold nanoparticles, as probes for cell tissue imaging under two‐photon excitation. We also demonstrated that the Au/pSi nanosystems induced cytotoxicity and phototoxicity
Abstract Mannosylglycerate (MG) and its derivatives have received much attention during the past decade, especially because they play an important role as thermal‐stabilizers of several enzymes. Here we report a new original synthetic method (2R)‐2‐(α‐D‐mannopyranosyl)glycerate, which was prepared according to five‐step procedure starting from commercially available 3,4‐ O ‐isopropylidene‐D‐mannitol glycerate source.
Porous silicon nanovectors carrying gold nanoparticles and functionalized with mannose species as tumor targeting agents demonstrate remarkable capability 2-photon imaging contrast agents. An important photodynamic efficiency of the is also observed in human breast cancer cells, formation reactive oxygen when exposed to two-photon light excitation. Such targeted porous silicon/gold provide an interesting opportunity for therapy, potential theranostic applications. More information can be...
Nanomaterials offer the potential for minimally invasive and focal therapies to reduce side-effects associated with systemic administration of anticancer drugs. Clinical treatment involving photodynamic therapy is particularly attractive since it allows spatial temporal control production highly cytotoxic singlet oxygen reactive species through local excitation a photosensitizer. Porous silicon nanoparticles (pSiNP), obtained by electrochemical etching crystalline followed ultrasonic...