A5077452494- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- Porphyrin and Phthalocyanine Chemistry
- Monoclonal and Polyclonal Antibodies Research
- Luminescence and Fluorescent Materials
- Immunotherapy and Immune Responses
- Venomous Animal Envenomation and Studies
- Lanthanide and Transition Metal Complexes
- vaccines and immunoinformatics approaches
- Advanced biosensing and bioanalysis techniques
- Glaucoma and retinal disorders
- Metal complexes synthesis and properties
- Immune Cell Function and Interaction
- Biochemical and Structural Characterization
- Nanoparticle-Based Drug Delivery
- Retinal and Optic Conditions
- Rabies epidemiology and control
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- RNA Interference and Gene Delivery
- Intraocular Surgery and Lenses
- Photoacoustic and Ultrasonic Imaging
- Nonlinear Optical Materials Studies
- Hemophilia Treatment and Research
- Antimicrobial Peptides and Activities
Institut des Biomolécules Max Mousseron
2018-2025
Université de Montpellier
2019-2024
Centre National de la Recherche Scientifique
2014-2024
École Nationale Supérieure de Chimie de Montpellier
2019-2024
Modélisation et Ingénierie des Systèmes Complexes Biologiques pour le Diagnostic
2008-2021
Pharmac
2020
Centre Occitanie-Montpellier
2018-2020
Bipar
2019-2020
Spartanburg Regional Healthcare System
2010-2017
Spartanburg Regional Medical Center
2015
In addition to the already described ligand L4a, two pyclen-based lanthanide chelators, L4b and L4c, bearing specific picolinate two-photon antennas (tailor-made for each targeted metal) one acetate arm arranged in a dissymmetrical manner, have been synthesized, form complete family of luminescent bioprobes: [EuL4a], [SmL4a], [YbL4b], [TbL4c], [DyL4c]. Additionally, symmetrically regioisomer L4a′ was also synthesized as well its [EuL4a′] complex highlight astonishing positive impact...
Herein, we report for the first time a biocompatible cross-linked trianglamine (Δ) network efficient iodine removal from vapor phase, water, and seawater. In could capture 6 g g-1 of iodine, ranking among most performant materials capture. liquid this is also capable capturing at high rates aqueous media (water seawater). This displayed fast adsorption kinetics, they are fully recyclable. study reveals affinity intrinsic cavity trianglamine. The synthesized extremely interesting since...
Abstract Two trispicolinate 1,4,7‐triazacyclonane (TACN)‐based ligands bearing three picolinate biphotonic antennae were synthetized and their Yb 3+ Gd complexes isolated. One series differs from the other by absence ( L 1 )/presence 2 ) of bromine atoms on antenna backbone, offering respectively improved optical singlet‐oxygen generation properties. Photophysical properties ligands, micellar Pluronic suspensions investigated. Complexes exhibit high two‐photon absorption cross‐section...
The systemic administration of IL-2 can act as a potent adjuvant for T cell-directed vaccine strategies. However, not only is the potentially toxic, but recent evidence suggests that it may also paradoxically limit duration and magnitude cytotoxic cell response. A recently identified cytokine, IL-15, shares many properties with provide preferential means augmenting responses. Although well characterized in vitro, there are few data on ability IL-15 to augment cell-mediated responses vivo. We...
Most methods available to predict protein epitopes are sequence based. There is a need for using 3D information prediction of discontinuous and derived immunogenic peptides.PEPOP uses the coordinates both clusters surface accessible segments that might correspond design peptides be used raise antibodies target cognate antigen at specific sites. To verify ability PEPOP identify epitopes, 13 crystallographically defined were compared with clusters: specificity ranged from 0.75 1.00,...
Epitope identification is essential for developing effective antibodies that can detect and neutralize bioactive proteins. Computational prediction a valuable time-saving alternative experimental identification. Current computational methods epitope are underused undervalued due to their high false positive rate. In this work, we targeted common properties of linear B-cell epitopes identified in an individual protein class (metalloendopeptidases) introduced method reduce the rate increase...
The concept of using two-photon excitation in the NIR for spatiotemporal control biological processes holds great promise. However, its use delivery nucleic acids has been very scarcely described and reported procedures are not optimal as they often involve potentially toxic materials irradiation conditions. This work prepares a simple system made biocompatible porous silicon nanoparticles (pSiNP) safe siRNA photocontrolled gene silencing cells upon excitation. PSiNP linked to an azobenzene...
This work investigates the electron-donating capabilities of two 10-π electron nitrogen bridgehead bicyclic [5,6]-fused ring systems, imidazo[1,2-a]pyridine and imidazo[1,5-a]pyridine rings. Eight compounds with varying positions electron-withdrawing moieties (TCF or DCI) coupled to imidazopyridine were synthesized studied. DCI-containing (Ib–IVb) exhibited a purely dipolar nature broad absorption bands, weak fluorescence, large Stokes shifts, strong solvatochromism. In contrast,...
Per- and polyfluoroalkyl substances (PFAS) are now a paramount concern in water remediation. Nowadays, urgent action is required for the development of advanced technologies aimed at capturing PFAS mitigating their impact. To offer solution, functional 3D printed hydrogel tailored designed to trap broad spectrum contaminants. The made photo-crosslinked dimethacrylate-ureido-trianglamine (DMU-Δ) Pluronic P123 dimethacrylate (PDM) fabricated by stereolithography (SLA). With aid 3D-printing,...
Loxoscelism is a necrotic-hemolytic syndrome caused by bites of brown spiders belonging to the genus Loxosceles. Many approaches for treatment Loxosceles poisoning have already been proposed, among which administration specific antivenom thought be more specific. We evaluated use peptides as immunogen raise in rabbits an antibody response that could protect animals from challenge Loxtox isoform LiD1, one main toxic component intermedia venom. Six antigenic regions LiD1 were mapped using SPOT...
Psalmopeotoxin I (PcFK1), a protein of 33 aminoacids derived from the venom spider Psalmopoeus Cambridgei, is able to inhibit growth Plasmodium falciparum malaria parasites with an IC50 in low micromolar range. PcFK1 was proposed act as ion channel inhibitor, although experimental validation this mechanism lacking. The surface loops have some sequence similarity parasite sequences cleaved by PfSUB1, subtilisin-like protease essential for egress merozoites and invasion into erythrocytes. As...
Recently, gold(III) porphyrins have gained great interest as anticancer drugs not only for the stability of but also functionalization porphyrin to allow bridging with another metal such platinum(II). We report here, first time, synthesis three new bimetal compounds containing a conjugated platinum diamine moiety through malonate obtain enhanced cytotoxicity from both metals combined phototoxicity porphyrin. The complexes differ in type ligand around platinum(II): ammonia (NH3),...
The development of nanosystems with enhanced photothermal and photoacoustic properties is crucial for advancing theranostic applications in cancer therapy. This study explores polymeric nanoparticles constituted by a biocompatible poly(ethylene glycol)‐block‐poly(benzyl malate) copolymer loaded metal‐bis(dithiolene) complexes (M = Ni, Pd, Pt). These nanoparticles, prepared via robust nanoprecipitation method, demonstrate uniform morphology, efficient encapsulation (~70%), tailored...
Abstract The adoptive transfer of tumor-specific T cells expanded in vitro can be significant therapeutic value select cancer patients. This strategy is limited though, as it often difficult, if not impossible, to obtain clinical value. TCR genes mature generate tumor-reactive provides a potential mechanism overcome these limitations. To evaluate the feasibility such an approach and quality resulting cells, we generated replication-deficient retroviral vectors using well-characterized OT-1...
Abstract Intense efforts of research are made for developing antitumor vaccines that stimulate T cell-mediated immunity. Tumor cells specifically express at their surfaces antigenic peptides presented by MHC class I and recognized CTL. hold promise the development novel cancer immunotherapies. However, peptide-based face two major limitations: weak immunogenicity tumor Ags low metabolic stability in biological fluids. These hurdles, which separate solutions exist, must, however, be solved...
Abstract Interleukin-12 can act as a potent adjuvant for T cell vaccines, but its clinical use is limited by toxicity. Paracrine administration of IL-12 could significantly enhance the response to such vaccines without toxicity associated with systemic administration. We have developed novel vaccine delivery system (designated F2 gel matrix) composed poly-N-acetyl glucosamine that has dual properties sustained-release and adjuvant. To test efficacy paracrine IL-12, we incorporated this...
The aim of the present work is development highly efficient targeting molecules to specifically address mesoporous silica nanoparticles (MSNs) designed for photodynamic therapy (PDT) prostate cancer. We chose strategy develop a novel compound that allows improvement cation-independent mannose 6-phosphate receptor, which overexpressed in This original sugar, dimannoside-carboxylate (M6C-Man) grafted on surface MSN PDT applications, leads higher endocytosis and thus increases efficacy MSNs.
Mesoporous organosilica nanoparticles (PHT-PMO) have been prepared from an octa-triethoxysilylated Zn phthalocyanine precursor. These PHT-PMO had no dark toxicity but high phototoxicity when irradiated at 650 nm, and remarkable near-infrared excited 760 810 nm. The were then aminated to promote electrostatic complexation with siRNA. Transfection experiments performed upon NIR irradiation photochemical internalization was very efficient, leading 65% luciferase extinction in MCF-7 cancer cells...
Three new biocompatible porphyrin-based oxygen photosensitisers were tested <italic>in vitro</italic> on breast cancer cells <italic>via</italic> 2P-PDT: one of them, 66 times more active than H<sub>2</sub>TPP, gave quite promising results for theranostic applications.
The present work was aimed at identifying the IgE-binding epitopic regions on surface of Cup s 3 allergen from common cypress Cupressus sempervirens, that are possibly involved in cross-reactivity reported between Cupressaceae species. Three main were mapped molecular 3, PR-5 thaumatin-like sempervirens. They correspond to exposed areas containing either electropositive (R, K) or electronegative (D, E) residues. A coalescence occurs epitopes #1 and #2, creates an extended allergen. Epitope...