A5102755883- Glioma Diagnosis and Treatment
- Cell Adhesion Molecules Research
- Nanoparticle-Based Drug Delivery
- Radiopharmaceutical Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Immune cells in cancer
- Cancer Research and Treatments
- Caveolin-1 and cellular processes
- Medical Imaging Techniques and Applications
- Microbial Natural Products and Biosynthesis
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Neuroblastoma Research and Treatments
- Radiation Therapy and Dosimetry
- Gene Regulatory Network Analysis
- Mathematical Biology Tumor Growth
- Chemical Synthesis and Analysis
- Synthetic Organic Chemistry Methods
- Cytokine Signaling Pathways and Interactions
- Cancer-related Molecular Pathways
- Erythropoietin and Anemia Treatment
- Circular RNAs in diseases
- Advanced Radiotherapy Techniques
Université de Lorraine
2013-2025
Centre National de la Recherche Scientifique
2012-2025
Centre de Recherche en Automatique de Nancy
2009-2024
Assistance Publique – Hôpitaux de Paris
2009-2017
Centre Val de Loire
2017
Centre Hospitalier Universitaire de Tours
2017
Hôpital Fernand-Widal
2017
Université Paris Cité
2017
Centre de Médecine Préventive
2014
Université de Strasbourg
2012
Integrins play a role in the resistance of advanced cancers to radiotherapy and chemotherapy. In this study, we show that high expression α5 integrin subunit compromises temozolomide-induced tumor suppressor p53 activity human glioblastoma cells. We found depletion increased temozolomide sensitivity. However, when cells were treated with activator nutlin-3a, protective effect on activation cell survival was lost. functional background, nutlin-3a downregulated subunit, thereby increasing...
This study aimed to evaluate the radiosensitizing potential of Au@DTDTPA(Gd) nanoparticles when combined with conventional external X-ray irradiation (RT) treat GBM.Complementary biological models based on U87 spheroids including 3D invasion assay, organotypic brain slice cultures, chronic cranial window model were implemented investigate impact RT treatments (10 Gy single dose; 5×2 or 2×5 Gy) tumor progression. The main mass and its infiltrative area analyzed. work focused invading cancer...
The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been shown previously directly impact bioactivity. For this, leveraged intrinsically broad specificity acyl transferase domain (AT12) modular synthase (PKS), which is responsible alkyl branching...
Despite recent progress in conventional therapeutic approaches, the vast majority of glioblastoma recur locally, indicating that a more aggressive local therapy is required. Interstitial photodynamic (iPDT) appears as very promising and complementary approach to therapies. However, an optimal fractionation scheme for iPDT remains indispensable requirement. To achieve major goal, we suggested following tumor response by non-invasive imaging monitoring. Nude rats bearing intracranial U87MG...
Abstract Caveolin‐1 plays a crucial role in the development of cancer and its progression. We previously reported that glioblastoma cells expressing low levels caveolin‐1 exerted more aggressive phenotype than high levels. Such was due to induction α 5 β 1 integrin subsequent depletion caveolin‐1. identified as transcriptional repressor integrin. The current study designed identify vitro , molecular mechanisms by which controls expression determine if negative correlation between integrins...
Tracers triggering αvβ3 integrins, such as certain RGD-containing peptides, were found promising in previous pilot studies characterizing high-grade gliomas. However, only limited comparisons have been performed with current PET tracers. This study aimed at comparing the biodistribution of 18F-fluorodeoxyglucose (18F-FDG) that 68Ga-NODAGA-RGD, an easily synthesized monomeric RGD compound rapid kinetics, two different rodent models engrafted human glioblastoma. Nude rodents bearing U87-MG...
Abstract: This article addresses the in silico–in vitro prediction issue of organometallic nanoparticles (NPs)-based radiosensitization enhancement. The goal was to carry out computational experiments quickly identify efficient nanostructures and then preferentially select most promising ones for subsequent vivo studies. To this aim, interdisciplinary introduces a new theoretical Monte Carlo ranking method tests it using 3 different NPs terms size composition. While predicted classical...
Malignant glioma patients have a life expectancy reduced to about 15 months despite aggressive surgery, radiotherapy (RT), and chemotherapy. Doxorubicin has shown marked cytotoxic effect against malignant cells in vitro. The brain exposure this drug is, however, hindered by the blood-brain barrier. Encapsulation of doxorubicin liposomal carriers been reduce toxicities improve tumors doxorubicin. In study, we evaluated radiosensitizing properties nonpegylated (Myocet, MYO) on two subcutaneous...
The invasive phenotype of glioma cells is thought to be responsible for recurrences. Ultrasmall Gd<sup>3+</sup> chelate-coated gold nanoparticles interfere with capacities migrate and invade due induced changes in intrinsic biomechanical properties.
Relationship between haemoglobin levels and tumour oxygenation has been already reported. The purpose of this work was to compare in human malignant glioma-bearing mice the sensitivity two well established techniques hypoxia assessment, especially their ability detect expected weak variations status associated level modifications. relationship glucose metabolism also investigated. Experiments were performed on a glioma (GBM Nan1) xenografted into nude mice. Twenty-four hours after...
In high-grade gliomas, the identification of patients that could benefit from EGFR inhibitors remains a challenge, hindering use these agents. Using xenografts models, we evaluated antitumor effect combined treatment "gefitinib + radiotherapy" and aimed to identify profile responsive tumors. Expression phosphorylated proteins involved in EGFR-dependent signaling pathways was analyzed 10 glioma models. We focused on three models anaplastic oligodendrogliomas (TCG2, TCG3 TCG4) harboring high...
Abstract The polyketide specialized metabolites of bacteria are attractive targets for generating analogues, with the goal improving their pharmaceutical properties. Here, we aimed to produce C-26 derivatives giant anti-cancer stambomycin macrolides using a mutasynthesis approach, as this position has been shown previously directly impact bioactivity. For this, leveraged intrinsically broad specificity acyl transferase domain (AT 12 ) modular synthase (PKS), which is responsible alkyl...