A5009250956- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- Porphyrin and Phthalocyanine Chemistry
- Cancer, Hypoxia, and Metabolism
- Photoacoustic and Ultrasonic Imaging
- Optical Imaging and Spectroscopy Techniques
- Healthcare Systems and Practices
- Angiogenesis and VEGF in Cancer
- Bladder and Urothelial Cancer Treatments
- Breast Cancer Treatment Studies
- Cancer Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Multiple and Secondary Primary Cancers
- Osteoarthritis Treatment and Mechanisms
- Spectroscopy Techniques in Biomedical and Chemical Research
- Click Chemistry and Applications
- Skin Protection and Aging
- Cancer Treatment and Pharmacology
- Colorectal Cancer Surgical Treatments
- Banking stability, regulation, efficiency
- bioluminescence and chemiluminescence research
- Breast Lesions and Carcinomas
- Health Systems, Economic Evaluations, Quality of Life
- Endometrial and Cervical Cancer Treatments
- Gastric Cancer Management and Outcomes
Université de Lorraine
2012-2022
Inserm
2008-2022
Centre d’Investigation Clinique Innovation Technologique de Nancy
2004-2022
Interdisciplinarité en Santé Publique Interventions et Instruments de mesure complexes – Région Est
2021-2022
Institut Jean Godinot
2019-2021
National Research University Higher School of Economics
2015-2020
Sorbonne Université
2009-2020
Pitié-Salpêtrière Hospital
2016-2020
Centre de Recherche en Automatique de Nancy
2006-2019
Institut de Cancérologie de Lorraine
2012-2019
Semiconductor quantum dots (QDs) could significantly impact the performance of biomedical near-infrared (NIR) imaging by providing fluorescent probes that are brighter and more photostable than conventional organic dyes. However, toxicity components NIR emitting II-VI IV-VI QDs have been made so far (Cd, Hg, Te, Pb, etc.) has remained a major obstacle to clinical use QDs. Here, we present synthesis CuInS(2)/ZnS core/shell in ( approximately 800 nm) with good yield stability even after...
Purpose Several models have been developed to predict nonsentinel lymph node (non-SN) status in patients with breast cancer sentinel (SN) metastasis. The purpose of our investigation was compare available a prospective, multicenter study. Patients and Methods In cohort 561 positive-SN who underwent axillary dissection, we evaluated the areas under receiver operating characteristic curves (AUCs), calibration, rates false negatives (FN), number group at low risk for non-SN calculated from nine...
Immunohistochemistry to active caspase-3, recently recommended for apoptosis detection, is inappropriate detect involving caspase-7. Cleavage of poly-ADP-ribose polymerase 1 (PARP-1), a major substrate both caspases, valuable marker apoptosis. Apoptosis evaluation induced in vitro either by paclitaxel or photodynamic treatment (PDT) with Foscan HT29 KB monolayer cells and spheroids yielded close percentage labeled whatever the antibody used, whereas control specimens, cleaved PARP (c-PARP)...
Objectives. To measure the frequency of and risk factors for rheumatic manifestations after chikungunya virus (CHIKV) infection to assess their impact on quality life (QoL). Methods. In a cohort study among 509 cases diagnosed in France, demographic clinical characteristics were collected at baseline, QoL status by 36-item short-form health survey (SF-36), short form Arthritis Impact Measurement Scales 2 (AIMS2-SF) General Health Questionnaire (GHQ-12) follow-up. SF-36 scores compared with...
Intracellular photosensitiser localisation significantly influences the mechanism of response to photodynamic therapy (PDT), since primary sites damage are closely related specific sensitiser distribution. Foscan® subcellular in MCF-7 human adenocarcinoma cell line has been studied by means confocal microscopy and microspectrofluorometry. The fluorescence topographic profiles recorded after cells costained with organelle-specific fluorescent probes revealed that presents low lysosomes a weak...
The cell membrane folate receptor (FR) is a molecular target for tumor-selective drug delivery, including delivery of photosensitizers anticancer photodynamic therapy (PDT). Tumor selectivity meta-tetra(hydroxyphenyl)chlorin (m-THPC), photosensitizer used in PDT clinical trials, demonstrates low tumor-to-normal epithelial uptake ratio. We report on the synthesis and photophysical properties m-THPC-like 1 conjugated to folic acid (compound 8). A comparative study accumulation 8 described....
The French Sentimag feasibility trial evaluated a new method for the localization of breast cancer sentinel lymph node (SLN) using Sienna+®, superparamagnetic iron oxide particles, and Sentimag® detection in comparison to standard technique (isotopes ± blue dye).We conducted prospective multicentric paired on 115 patients. SLN was performed both magnetic method. Detection rate concordance between tracers were calculated. Post-operative complications assessed after 30 days.Results are based...
<b>Objective:</b> To assess direct costs associated with ankylosing spondylitis (AS). determine which variables, including country, predict costs. <b>Methods:</b> 216 patients AS from the Netherlands, France, and Belgium participated in a two year observational study filled bimonthly economic questionnaires. Disease related healthcare resource use was measured were calculated societal perspective (true cost estimates) financial (country-specific tariffs). Predictors of assessed using Cox's...
Cancers located on the internal wall of bladders can be detected in image sequences acquired with endoscopes. The clinical diagnosis and follow-up facilitated by building a unique panoramic bladder images from different viewpoints. This process, called mosaicing, consists two steps. In first step, consecutive are pairwise registered to find local transformation matrices linking geometrically images. second all placed common global coordinate system. this contribution, mutual...
mTHPC is a non polar photosensitizer used in photodynamic therapy. To improve its solubility and pharmacokinetic properties, liposomes were proposed as drug carriers. Binding of liposomal to serum proteins stability carriers are major importance for PDT efficacy; however, neither was reported before. We studied binding human using size-exclusion chromatography. Liposomes destruction measured by nanoparticle tracking analysis (NTA). Inclusion into conventional (Foslip(®)) PEGylated...
Near-infrared (NIR) imaging of the lymphatic system offers a sensitive, versatile, and accurate lymph node mapping to locate first, potentially metastatic, draining nodes in operating room. Many luminescent nanoprobes have received great attention this field, design nontoxic bright nanosystems is crucial importance. Fluorescent NIR-emitting dye doped silica nanoparticles represent valuable platforms fulfill these scopes, providing sufficient brightness, resistance photobleaching, hydrophilic...
Keywords: mTHPC, liposomes, drug release, liposomal pharmacokinetics, biodistribution, photodynamic therapy
The present study investigates the relationship between subcellular localisation of Foscan® and intrinsic apoptotic pathway post Foscan®-based photodynamic therapy (PDT). With this purpose, mammary carcinoma MCF-7 cells were incubated with for 3 or 24 h then subjected to equitoxic light doses. Fluorescence microscopy revealed very good co-localization endoplasmic reticulum (ER) Golgi apparatus after incubation cells. Progressive increase in time shows leakage from apparatus. Twenty-four...