A5028709583- Photodynamic Therapy Research Studies
- Angiogenesis and VEGF in Cancer
- Nanoplatforms for cancer theranostics
- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Click Chemistry and Applications
- Photoacoustic and Ultrasonic Imaging
- Eicosanoids and Hypertension Pharmacology
- Mathematical Biology Tumor Growth
- Peptidase Inhibition and Analysis
- Antiplatelet Therapy and Cardiovascular Diseases
- Photochromic and Fluorescence Chemistry
- Estrogen and related hormone effects
- Radiation Therapy and Dosimetry
- Radiopharmaceutical Chemistry and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Optical Coherence Tomography Applications
- Nanoparticle-Based Drug Delivery
- Ubiquitin and proteasome pathways
- Apelin-related biomedical research
- Neurogenesis and neuroplasticity mechanisms
- Advanced Nanomaterials in Catalysis
- Cerebrovascular and genetic disorders
- Atomic and Subatomic Physics Research
- Porphyrin and Phthalocyanine Chemistry
Université de Lorraine
2015-2025
Centre National de la Recherche Scientifique
2006-2025
Centre de Recherche en Automatique de Nancy
2014-2024
University of Liège
2012
Délégation Centre-Est
2006-2010
Centre d'expertise et de recherche en infrastructures urbaines
2006-2009
Radiotherapy is recommended for the treatment of brain tumors such as glioblastoma (GBM) and metastases. Various curative palliative scenarios suggest improved local-regional control. Although underlying mechanisms are not yet clear, additional therapeutic effects have been described, including proximity abscopal reactions at site. Clinical preclinical data that immune system plays an essential role in regulating non-targeted radiotherapy GBM. This article reviews current biological caused...
Abstract: Despite combined treatments, glioblastoma outcome remains poor with frequent local recurrences, indicating that a more efficient and therapy is needed. In this way, vascular-targeted photodynamic (VTP) could help tumor eradication by destroying its neovessels. study, we designed polysiloxane-based nanoparticle (NP) combining magnetic resonance imaging (MRI) contrast agent, photosensitizer (PS) new ligand peptide motif (KDKPPR) targeting neuropilin-1 (NRP-1), receptor overexpressed...
The use of numerical models to predict radiosensitizing properties induced by metal-based nanoparticles (NPs) remains a real challenge in oncology. As most the interactions due radiation biological environments originate from secondary particles produced, we aim formalize relationship between these particles, irradiation dose and NP concentration, optimize mathematical tools for assessing NP-induced radiosensitization. GATE simulations were carried out demonstrate linear affine specific...
Background: Local recurrences of glioblastoma (GBM) after heavy standard treatments remain frequent and lead to a poor prognostic. Major challenges are the infiltrative part tumor tissue which is ultimate cause recurrence. The therapeutic arsenal faces difficulty eradicating this infiltrating while increasing targeting endogenous stromal cells such as angiogenic endothelial cells. In aim, neuropilin-1 (NRP-1), transmembrane receptor mainly overexpressed by vascular system associated with...
Abstract Cancer is the second leading cause of death worldwide after cardiovascular disease. Depending on type and location tumor, several cancer treatments are implemented. Among these, three most conventional therapies surgery, radiotherapy chemotherapy. However, there other therapeutic approaches such as photodynamic therapy (PDT). PDT relies combined action light, a photoactivable molecule called photosensitizer (PS) molecular oxygen. Most PSs used for clinical applications not...
Glioblastoma (GBM) is the most difficult brain cancer to treat, and photodynamic therapy (PDT) emerging as a complementary approach improve tumor eradication. Neuropilin-1 (NRP-1) protein expression plays critical role in GBM progression immune response. Moreover, various clinical databases highlight relationship between NRP-1 M2 macrophage infiltration. In order induce effect, multifunctional AGuIX®-design nanoparticles were used combination with magnetic resonance imaging (MRI) contrast...
Because angiogenic endothelial cells of the tumor vasculature represent an interesting target to potentiate antivascular effect photodynamic therapy, we recently described conjugation a photosensitizer [5-(4-carboxyphenyl)-10,15,20-triphenylchlorin (TPC)], via spacer [6-aminohexanoic acid (Ahx)], vascular growth factor receptor-specific heptapeptide [H-Ala-Thr-Trp-Leu-Pro-Pro-Arg-OH (ATWLPPR)] and showed that TPC-Ahx-ATWLPPR binds neuropilin-1. peptides often display low stability in...
Due to their very poor prognosis and a fatal outcome, secondary brain tumors are one of the biggest challenges in oncology today. From point view early diagnosis these micro- macro-tumors, sensitivity specificity diagnostic tools constitute an obstacle. Molecular imaging, such as Positron Emission Tomography (PET), is promising technique but remains limited search for cerebral localizations, given commercially available radiotracers. Indeed, [18F]FDG PET constrained by physiological fixation...
Radiotherapy is recommended for the treatment of brain tumors such as glioblastoma (GBM) and metastases. Various curative palliative scenarios suggest improved local-regional control. Although underlying mechanisms are not yet clear, additional therapeutic effects have been described, including proximity abscopal reactions at site. Clinical preclinical data that immune system plays an essential role in regulating non-targeted radiotherapy GBM. This article reviews current biological caused...