A5054471290- Inflammation biomarkers and pathways
- Gut microbiota and health
- Kawasaki Disease and Coronary Complications
- Apelin-related biomedical research
- Clinical Nutrition and Gastroenterology
- Nutrition and Health in Aging
- Sports and Physical Education Research
- Renal Diseases and Glomerulopathies
- Gastrointestinal motility and disorders
- Platelet Disorders and Treatments
- Methodologies in Health Research and Practice
- Inflammatory Bowel Disease
- Diet and metabolism studies
- Clostridium difficile and Clostridium perfringens research
- Helicobacter pylori-related gastroenterology studies
Centre Hospitalier Régional et Universitaire de Nancy
2025
Université de Lorraine
2023-2025
Inserm
2023-2025
Centre d’Investigation Clinique Innovation Technologique de Nancy
2024
Centre de Médecine Préventive
2023
Non-absorbed dietary emulsifiers, including carboxymethylcellulose (CMC), directly disturb intestinal microbiota, thereby promoting chronic inflammation in mice. A randomised controlled-feeding study (Functional Research on Emulsifiers Humans, FRESH) found that CMC also detrimentally impacts microbiota some, but not all, healthy individuals. This aimed to establish an approach for predicting individual's sensitivity emulsifiers via their baseline microbiota. We evaluated the ability of vitro...
Abstract Aims Although the risk of thrombosis is well documented for inflammatory bowel disease [IBD] patients, underlying pathological mechanism seems to be different from other thrombotic conditions. Determining factors responsible increased in IBD would help improve management this frequent complication. Methods We studied interplay between platelets, coagulation, and von Willebrand factor [VWF] 193 patients experimental models [acute chronic] colitis wild-type VWF-deficient mice. Results...
The immuno-receptor Triggering Expressed on Myeloid cells-1 (TREM-1) is activated during bacterial infectious diseases, where it amplifies the inflammatory response. Small studies suggest that TREM-1 could be involved in viral infections, including COVID-19. We here aim to decipher whether plasma concentration of soluble form (sTREM-1) predict outcome hospitalized COVID-19 patients.We conducted a multicentre prospective observational study 3 university hospitals France. Consecutive patients...
Abstract Background Inflammatory bowel diseases (IBD) are chronic characterized by inflammation of the mucosa linked to an alteration intestinal microbiota and overreaction immune system. The prevalence IBD is increasing in industrialized countries where we find a “Western Diet” rich refined sugars saturated fats but low fiber essential unsaturated fatty acids1. Thus, nutrition seems be important environmental factor involved occurrence IBD, however, underlying biological mechanisms still...
Introduction The low-grade inflammatory state present in obesity leads to the development and perpetuation of comorbidities associated with obesity. Our laboratory has been working for several years on an amplification loop response mediated by TREM-1 (Triggering Receptor Expressed Myeloid Cells-1). It is implicated many acute (septic shock) chronic (IBD) diseases. Previously, shown be overexpressed adipose liver tissue obese diabetic patients, but its impact never characterized these...