Michel Klein

ORCID: 0000-0003-4119-1846
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About
Contact & Profiles
Research Areas
  • Semantic Web and Ontologies
  • Mental Health Research Topics
  • Advanced Database Systems and Queries
  • Digital Mental Health Interventions
  • Service-Oriented Architecture and Web Services
  • Behavioral Health and Interventions
  • Mobile Health and mHealth Applications
  • Physical Activity and Health
  • Biomedical Text Mining and Ontologies
  • Multi-Agent Systems and Negotiation
  • HIV Research and Treatment
  • Obesity, Physical Activity, Diet
  • Impact of Technology on Adolescents
  • Opinion Dynamics and Social Influence
  • Context-Aware Activity Recognition Systems
  • Human-Automation Interaction and Safety
  • Innovative Human-Technology Interaction
  • Natural Language Processing Techniques
  • Health and Medical Studies
  • Artificial Intelligence in Law
  • Child and Adolescent Psychosocial and Emotional Development
  • Cardiac and Coronary Surgery Techniques
  • Liver physiology and pathology
  • Business Process Modeling and Analysis
  • Crime Patterns and Interventions

Vrije Universiteit Amsterdam
2015-2024

Amsterdam University Medical Centers
2019-2024

American University
2024

Cancer Center Amsterdam
2022-2024

Centre Hospitalier Régional et Universitaire de Nancy
2002-2023

Université de Montpellier
2020-2021

Montpellier Business School
2020

Riyadh Elm University
2019

CNI College
2017

Saarland University
2002-2015

XML and RDF are the current standards for establishing semantic interoperability on Web, but addresses only document structure. better facilitates interoperation because it provides a data model that can be extended to address sophisticated ontology representation techniques. We explain role of ontologies in architecture Semantic Web. then briefly summarize key elements RDF, showing why using as tool will ineffective long run. argue further inference layer is needed top Web's layers,...

10.1109/4236.877487 article EN IEEE Internet Computing 2000-01-01

10.1007/s10115-003-0137-2 article EN Knowledge and Information Systems 2004-06-28

Background Research on digital technology to change health behavior has increased enormously in recent decades. Due the interdisciplinary nature of this topic, knowledge and technologies from different research areas are required. Up now, it is not clear how those fields combined actual applications. A comprehensive analysis that systematically maps explores use within emerging field Objective This study aims provide an overview area around design development for explore trends patterns....

10.2196/13311 article EN cc-by JMIR mhealth and uhealth 2019-09-26

The liver has a large capacity for regeneration after resection. However, below critical level of future remnant volume (FLRV), partial hepatectomy is accompanied by significant increase postoperative failure. There accumulating evidence the contribution bone marrow stem cells (BMSCs) to participate in regeneration. Here we report on three patients subjected intraportal administration autologous CD133+ BMSCs subsequent portal venous embolization right segments, used expand left lateral...

10.1634/stemcells.2004-0283 article EN Stem Cells 2005-03-24

ABSTRACT T-cell-mediated immune effector mechanisms play an important role in the containment of human immunodeficiency virus/simian virus (HIV/SIV) replication after infection. Both vaccination- and infection-induced T-cell responses are dependent on host major histocompatibility complex classes I II (MHC-I MHC-II) antigens. Here we report that both inherent, host-dependent to SIV mac251 infection vaccination-induced viral antigens were able reduce and/or CD4 + loss. presence MHC-I...

10.1128/jvi.76.1.292-302.2002 article EN Journal of Virology 2002-01-01

We have identified the tRNAs which are incorporated into both wild-type human immunodeficiency virus type 1 strain IIIB (HIV-1IIIB) produced in COS-7 cells transfected with HIV-1 proviral DNA and mutant, noninfectious HIV-1Lai particles a genetically engineered Vero cell line. The mutant contains nucleotides 678 to 8944; i.e., long terminal repeats primer binding site absent. As analyzed by two-dimensional polyacrylamide gel electrophoresis, contain four major-abundance tRNA species, include...

10.1128/jvi.67.6.3246-3253.1993 article EN Journal of Virology 1993-06-01

ABSTRACT Mycobacterium tuberculosis is estimated to infect 80 100 million people annually, the majority of whom do not develop clinical (TB) but instead maintain infection in a latent state. These individuals generally become positive response tuberculin skin test and may TB at later date, particularly if their immune systems are compromised. Latently infected interesting for two reasons. First, they an important reservoir M. , which needs be considered control. Second, detected prior...

10.1128/cvi.13.2.179-186.2006 article EN Clinical and Vaccine Immunology 2006-02-01

To prospectively evaluate the effectiveness of portal vein embolization (PVE) and CD133(+) bone marrow stem cell (BMSC) administration to liver, compared with PVE alone, augment hepatic regeneration in patients large malignancies.The study was approved by institutional ethics committee; informed consent obtained. Thirteen underwent liver segments I IV-VIII stimulate prior extended right hepatectomy. In six (three men, three women; mean age, 61 years; range, 46-72 years) a future remnant...

10.1148/radiol.2431060625 article EN Radiology 2007-02-21

Collective decision making involves on the one hand individual mental states such as beliefs, emotions and intentions, other interaction with others possibly different states. Achieving a satisfactory common group which all agree requires that are adapted to each by social interaction. Recent developments in neuroscience have revealed neural mechanisms mutual adaptation can be realised. These not only enable intentions converge an emerging decision, but at same time achieve shared underlying...

10.1007/s10458-012-9201-1 article EN cc-by Autonomous Agents and Multi-Agent Systems 2012-06-20

Live attenuated viral vectors that express human immunodeficiency virus (HIV) antigens are being developed as potential vaccines to prevent HIV infection. The first phase 2 trial with a canarypox vector (vCP205, which expresses gp120, p55, and protease) was conducted in 435 volunteers without gp120 boosting, expand the safety database compare immunogenicity of who were at higher risk lower for Neutralizing antibodies MN strain stimulated 94% given vCP205 plus 56% alone. CD8+ cytotoxic T...

10.1086/319863 article EN The Journal of Infectious Diseases 2001-05-01

Antibodies generated by candidate HIV-1 vaccines in a phase I clinical trial were assessed for neutralizing activity with panel of eight well-characterized, genetically diverse clade B primary isolates having an R5 phenotype. The consisted one three different recombinant canarypox vectors expressing membrane-anchored HIV-1MNgp120 (ALVAC vCP205, vCP1433, and vCP1452) followed boosting soluble gp160 hybrid consisting MNgp120 the majority gp41 from strain IIIB. Serum samples subset volunteers...

10.1089/088922200750054756 article EN AIDS Research and Human Retroviruses 2000-12-10

10.1016/s0169-023x(02)00041-1 article EN Data & Knowledge Engineering 2002-06-01

10.1016/j.websem.2011.05.003 article EN Journal of Web Semantics 2011-05-22

10.1016/j.jbi.2014.05.005 article EN publisher-specific-oa Journal of Biomedical Informatics 2014-05-21
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