A5011960144- Sphingolipid Metabolism and Signaling
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Lipid Membrane Structure and Behavior
- Alzheimer's disease research and treatments
- Cellular transport and secretion
- Retinal Development and Disorders
Laboratoire Animal et Agroécosystèmes
2020-2024
Université de Lorraine
2022-2024
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2024
Docosahexaenoic acid (DHA, C22:6 ω3) may be involved in various neuroprotective mechanisms that could prevent Alzheimer's disease (AD). Its influence has still been little explored regarding the dysfunction of endolysosomal pathway, known as an early key event physiopathological continuum triggering AD. This result from accumulation degradation products precursor protein AD, particular C99 fragment, capable interacting with endosomal proteins and thus contributing to altering this pathway...
Perturbations of cholesterol metabolism have been linked to neurodegenerative diseases. Glia-neuron crosstalk is essential achieve a tight regulation brain trafficking. Adequate supply from glia via apolipoprotein E-containing lipoproteins ensures neuronal development and function. The lipolysis-stimulated lipoprotein receptor (LSR), plays an important role in homeostasis. Aged heterozygote Lsr+/- mice show altered distribution increased susceptibility amyloid stress. Since LSR expression...