A5076247384- 3D Printing in Biomedical Research
- Hydrogels: synthesis, properties, applications
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Electrospun Nanofibers in Biomedical Applications
- Neuroscience and Neural Engineering
- Supramolecular Self-Assembly in Materials
- Innovative Microfluidic and Catalytic Techniques Innovation
- Curcumin's Biomedical Applications
- EEG and Brain-Computer Interfaces
- Advanced Drug Delivery Systems
- Tissue Engineering and Regenerative Medicine
- Conducting polymers and applications
- Cell Image Analysis Techniques
- Advanced biosensing and bioanalysis techniques
- Extracellular vesicles in disease
- Graphene and Nanomaterials Applications
- Osteoarthritis Treatment and Mechanisms
- Fatty Acid Research and Health
- Pluripotent Stem Cells Research
- Bone Tissue Engineering Materials
- Cholesterol and Lipid Metabolism
- Nanofabrication and Lithography Techniques
- Neuroinflammation and Neurodegeneration Mechanisms
- Optical Imaging and Spectroscopy Techniques
New York University Abu Dhabi
2023-2025
Université de Lorraine
2019-2024
Centre National de la Recherche Scientifique
2022-2024
Laboratoire d'Analyse et d'Architecture des Systèmes
2022-2024
Roche (France)
2024
Université de Toulouse
2024
Laboratoire des Biomolécules
2019-2022
Brigham and Women's Hospital
2020-2022
Harvard University
2020-2022
Laboratoire d'Ingénierie des Biomolécules
2021
Curcumin, a natural polyphenol, has many biological properties, such as anti-inflammatory, antioxidant, and anti-carcinogenic yet, its sensitivity to light, oxygen, heat, low solubility in water renders preservation bioavailability challenging. To increase bioaccessibility, we fabricated nanoliposomes chitosan-coated encapsulating curcumin, evaluated the systems terms of their physicochemical characteristics release profiles simulated gastrointestinal mediums. Chitosan-coating enhanced...
Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive agents that can surpass these limitations is a necessity. One such agent, curcumin, polyphenolic compound derived from turmeric, has been widely investigated for its potential anti-inflammatory effects over the last 40 years. However, poor bioavailability of caused by low absorption, limits clinical use. In order to solve this issue, in study, curcumin was encapsulated...
In additive manufacturing, bioink formulations govern strategies to engineer 3D living tissues that mimic the complex architectures and functions of native for successful tissue regeneration. Conventional 3D-printed are limited in their ability alter fate laden cells. Specifically, efficient delivery gene expression regulators (i.e. microRNAs (miRNAs)) cells bioprinted has remained largely elusive. this study, we explored inclusion extracellular vesicles (EVs), naturally occurring...
The development of nanocomposite hydrogels that take advantage hierarchic building blocks is gaining increased attention due to their added functionality and numerous biomedical applications. Gathering on the unique properties these platforms, herein we report synthesis bioactive comprising naringin-loaded salmon-derived lecithin nanosized liposomal gelatin methacryloyl (GelMA) macro-sized for embedding. This platform takes liposomes’ significant drug loading capacity role in hydrogel...
Abstract Corneal blindness, a leading cause of visual impairment globally, has created pressing need for alternatives to corneal transplantation due the severe shortage donor tissues. In this study, we present novel interpenetrating network hydrogel composed gelatin methacryloyl (GelMA) and oxidized carboxymethyl cellulose (OxiCMC) bioprinting biomimetic stroma equivalent. We tested different combinations GelMA OxiCMC optimize printability subsequently evaluated these using rheological...
Nerve guide conduits (NGCs) are promising alternatives to autografts for the treatment of peripheral nerve injuries. These designed replace tissue that has been damaged or removed from injured region. An ideal conduit should effectively bridge gap and induce cell growth regeneration. Current FDA-approved NGCs predominantly address gaps smaller than 2 cm fabricated rigid synthetic polymers. Nevertheless, cells prefer softer substrates more closely mimic extracellular matrix (ECM). While...
Polymeric hydrogels are currently at the center of research due to their particular characteristics. They have tunable physical, chemical, and biological properties making them a material choice for large range applications. Polymer-composite nanocomposite were developed enhance native hydrogel’s include numerous functionalities. In this work, alginate/gelatin-methacryloyl-based interpenetrating polymer network prepared with different alginate concentrations investigated before after...
Nanoliposomes are widely used as delivery vehicles for active compounds. from rapeseed phospholipids were incorporated into interpenetrating polymer network hydrogels of gelatin methacryloyl and alginate. The multiscale physicochemical properties the studied both on surface through thickness 3D network. obtained composite exhibited strong mechanical a highly porous surface. blend ratio, well concentration nanoliposomes, affects hydrogels. Nanofunctionalized induced keratinocyte growth....
The low efficiency in transfecting rat- and human-derived chondrocytes have been hampering developments the field of cartilage biology. Transforming growth factor (TGF)-β1 has shown positive effects on chondrocytes, but its applications remain limited due to short half-life, stability poor penetration into cartilage. Naturally derived liposomes be promising delivery nanosystems their similarities with biological membranes. Here, we used agro-based rapeseed liposomes, which contains a high...
Breast cancer is the leading cause of death from among women. Higher consumption dietary marine n-3 long-chain polyunsaturated fatty acids (LC-PUFAs) associated with a lower risk breast cancer. Eicosapentaenoic acid (EPA) and docosahexaenoic (DHA) are two LC-PUFAs found in fish exert anticancer effects. In this study, natural marine-derived lecithin that rich various (PUFAs) was extracted salmon heads transformed into nanoliposomes. These nanoliposomes were characterized cultured lines...
Curcumin is a hydrophobic drug gaining growing attention because of its high availability, innocuity, and anticancer, antitumoral, antioxidative activity. However, poor bioavailability in the human body, caused by low aqueous solubility fast degradation, presents big hurdle for oral administration. Here, we used nano-vesicles made phospholipids to carry protect curcumin membrane. Various amounts were encapsulated produced phospholipid system form drug-loaded liposomes. Curcumin’s...
Investigations in cartilage biology have been hampered by the limited capacity of chondrocytes, especially rats and humans, to be efficiently transfected. Liposomes are a promising delivery system due their lipid bilayer structure similar biological membrane. Here we used natural rapeseed lecithin, which contains high level mono- poly-unsaturated fatty acids, evaluate cytocompatibility these phospholipids as future potential carriers biomolecules joint regenerative medicine. Results show...
There is a growing interest for complex in vitro environments that closely mimic the extracellular matrix and allow cells to grow microenvironments are closer one vivo. Protein-based matrices especially hydrogels can answer this need, thanks their similarity with cell microenvironment ease of customization. In study, an experimental design was conducted study influence synthesis parameters on physical properties gelatin methacryloyl (GelMA). Temperature, ratio methacrylic anhydride over...
Curcumin is known for its anti-inflammatory, neuroprotective, and antioxidant properties, but use in biological applications hindered by sensitivity to light, oxygen, temperature. Furthermore, due low water solubility, curcumin has a poor pharmacokinetic profile bioavailability. In this study, we evaluated the potential application of as neuroprotective agent encapsulated RGD peptide-PEGylated nanoliposomes developed from salmon-derived lecithin. Salmon lecithin, rich polyunsaturated fatty...