A5059482218- Bariatric Surgery and Outcomes
- Diet and metabolism studies
- Diabetes Treatment and Management
- Body Contouring and Surgery
- Dementia and Cognitive Impairment Research
- Cardiovascular Disease and Adiposity
- Obesity and Health Practices
- Gastric Cancer Management and Outcomes
- COVID-19 and healthcare impacts
- Nutrition and Health in Aging
- Diabetes and associated disorders
- Body Composition Measurement Techniques
- Regulation of Appetite and Obesity
- Extracellular vesicles in disease
- Health and Lifestyle Studies
- Trauma and Emergency Care Studies
- Nutritional Studies and Diet
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiac, Anesthesia and Surgical Outcomes
- Adipokines, Inflammation, and Metabolic Diseases
- Functional Brain Connectivity Studies
- Pancreatic function and diabetes
- COVID-19 and Mental Health
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
Consorci Institut D'Investigacions Biomediques August Pi I Sunyer
2016-2025
Hospital Clínic de Barcelona
2016-2025
Instituto de Salud Carlos III
2020-2025
Centro de Investigación Biomédica en Red
2019-2025
Centro de Investigación Biomédica en Red Diabetes y Enfermedades Metabólicas Asociadas
2025
Hospital Universitari de Vic
2008-2024
Fundació Clínic per a la Recerca Biomèdica
2023-2024
Hospital Universitario Son Espases
2024
Medical University of South Carolina
2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2021-2023
In Brief Objective: To identify the rates and predictors of long-term remission recurrence type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGBP) or sleeve gastrectomy (SG). Background: The durability improvement T2DM bariatric surgery is not well characterized. Methods: One hundred fifty-three subjects with (RYGBP: n = 98; SG: 55) were evaluated for disease throughout 35.4 ± 13.5 months' follow-up. surgery, demographic, anthropometric, biochemical parameters ascertained as...
To construct and validate a scoring system for evidence-based selection of bariatric metabolic surgery procedures according to severity type 2 diabetes (T2DM).Roux-en-Y gastric bypass (RYGB) sleeve gastrectomy (SG) account >95% in United States patients with T2DM. date, there is no validated model guide procedure based on long-term glucose control T2DM.A total 659 T2DM who underwent RYGB SG at an academic center the had minimum 5-year follow-up (2005-2011) were analyzed generate model. The...
OBJECTIVE Glucagon like peptide-1 (GLP-1) has been suggested as a major factor for the improved glucose tolerance ensuing after Roux-en-Y gastric bypass (RYGBP) surgery. We examined effect of blocking endogenous GLP-1 action on in subjects with sustained remission type 2 diabetes mellitus (T2DM) present before RYGBP. RESEARCH DESIGN AND METHODS Blood glucose, insulin, C-peptide, glucagon, GLP-1, and glucose-dependent insulinotropic peptide levels were measured meal challenge either...
OBJECTIVE To characterize the status of cardiometabolic risk factors after late relapse type 2 diabetes mellitus (T2DM) and to identify predicting initial remission following bariatric surgery construct prediction models for clinical practice. RESEARCH DESIGN AND METHODS Outcomes 736 patients with T2DM who underwent Roux-en-Y gastric bypass (RYGB) or sleeve gastrectomy (SG) at an academic center (2004–2012) had ≥5 years’ glycemic follow-up were assessed. Of patients, 425 (58%) experienced...
// Jordi Pegueroles 1, 2, * , Amanda Jiménez 3, 5, Eduard Vilaplana 2 Victor Montal María Carmona-Iragui Adriana Pané 3 Daniel Alcolea Laura Videla Anna Casajoana 4 Clarimón Emilio Ortega 6 Josep Vidal 7 Rafael Blesa Alberto Lleó and Juan Fortea for the Alzheimer’s Disease Neuroimaging Initiative ** 1 Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau-Biomedical Research Institute Pau, Barcelona, Spain Centro...
Although GLP-1 has been suggested as a major factor for the marked improvement of glucose tolerance commonly seen after sleeve gastrectomy (SG), several observations challenge this hypothesis. To better understand role in remission type 2 diabetes mellitus (T2DM) long term SG humans, we conducted two separate cross-sectional studies: 1) response to standardized mixed liquid meal (SMLM) was compared subjects with T2DM antedating but different long-term (>2 years) outcomes (remission,...
Abstract Introduction The SPIN (Sant Pau Initiative on Neurodegeneration) cohort is a multimodal biomarker platform designed for neurodegenerative disease research following an integrative approach. Methods Participants of the provide informed consent to donate blood and cerebrospinal fluid samples, receive detailed neurological neuropsychological evaluations, undergo structural 3T brain MRI scan. A subset also undergoes other functional or imaging studies (video‐polysomnogram, 18...
Weight loss has been proposed as a sign of pre-clinical Alzheimer Disease (AD). To test this hypothesis, we have evaluated the association between longitudinal changes in weight trajectories, cognitive performance, AD biomarker profiles and brain structure 363 healthy controls from Alzheimer´s Neuroimaging Initiative (mean follow-up 50.5±30.5 months). Subjects were classified according to body trajectory into group (WLG; relative ≥ 5%) non-weight (non-WLG; < 5%). Linear mixed effects models...
To evaluate the association between glucagon-like peptide 1 (GLP-1) secretion and long-term (>2 years) outcome of type 2 diabetes mellitus (T2DM) after Roux-en-Y gastric bypass (RYGBP).Cross-sectional study in 18 T2DM morbidly obese subjects who underwent RYGBP but differed (remission: G1, n = 6; relapse: G2, lack remission: G3: 6). Groups were matched for their sex, age, body mass index. The GLP-1, glucose, C-peptide, glucagon responses to a standardized test meal (STM) evaluated. Insulin...
Roux-en-Y gastric bypass (RYGBP) and sleeve gastrectomy (SG) have been associated with a high remission rate of type 2 diabetes mellitus (T2DM). However, whether such is full restoration postprandial glucose profile and/or the potentially nonrestored glycemic altered beta cell function, relapse T2DM over time unknown.Cross-sectional studies comparing (1) proinsulin/insulin response to standardized liquid mixed meal (SLMM) challenge (n = 31), (2) in normal living conditions assessed using...
Obesity and type 2 diabetes are associated with cognitive dysfunction. Because the hypothalamus is implicated in energy balance control memory disorders, we hypothesized that specific neurons this brain region at interface of metabolism cognition. Acute obesogenic diet administration mice impaired recognition due to defective production neurosteroid precursor pregnenolone hypothalamus. Genetic interference synthesis by Star deletion hypothalamic POMC, but not AgRP neurons, deteriorated...
Preclinical research implicates hypothalamic inflammation (HI) in obesity and type 2 diabetes pathophysiology. However, their pathophysiological relevance potential reversibility need to be better defined. We sought evaluate the effect of bariatric surgery (BS) on radiological biomarkers HI association between severity such alterations post-BS weight loss (WL) trajectories. The utility cerebrospinal fluid large extracellular vesicles (CSF-lEVs) enriched for microglial astrocyte markers...
Abstract Following bariatric surgery (BS) patients have an increased risk of alcohol misuse. Purpose This 1-year cross-sectional study in potential BS candidates had several objectives: (a) assess the prevalence risky drinking, use disorder (AUD), and other substance use/disorder; (b) compare these behaviors to that general Spanish population; (c) determine proportion with positive results toxicology tests; (d) predictive factors drinking. Setting: tertiary university hospital. Materials...
Abstract BACKGROUND In Down syndrome (DS) and Alzheimer's disease (AD), nerve growth factor precursor protein (proNGF) accumulates in the brain. However, its non‐invasive detection using neuron‐derived extracellular vesicles (NDEVs) from plasma remains unexplored. METHODS We included 139 adults with DS (45 asymptomatic [aDS], 94 symptomatic for AD [sDS]) 37 healthy controls. NDEVs were isolated plasma. ProNGF tetraspanin (CD81) quantified by enzyme‐linked immunosorbent assay. assessed...