A5000945584- Dementia and Cognitive Impairment Research
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Medical Image Segmentation Techniques
- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Nutritional Studies and Diet
- Brain Tumor Detection and Classification
- Neural Networks and Applications
- Radiomics and Machine Learning in Medical Imaging
- Blind Source Separation Techniques
- Neurobiology of Language and Bilingualism
- Traditional Chinese Medicine Studies
- Cholesterol and Lipid Metabolism
- Genetic Neurodegenerative Diseases
- Health, Environment, Cognitive Aging
- Image and Signal Denoising Methods
- Health Systems, Economic Evaluations, Quality of Life
- Metabolomics and Mass Spectrometry Studies
- AI in cancer detection
- Neural dynamics and brain function
- Spectroscopy Techniques in Biomedical and Chemical Research
- Medical Imaging Techniques and Applications
- Alcoholism and Thiamine Deficiency
- Advanced Memory and Neural Computing
Fundacion CITA Alzheimer
2016-2025
Biogipuzkoa Health Research Institute
2018
National University of Distance Education
2018
Karolinska University Hospital
2018
Karolinska Institutet
2018
Research Network (United States)
2018
University of the Basque Country
2006-2010
Abstract Introduction Cortical mean diffusivity (MD) and free water fraction (FW) changes are proposed biomarkers for Alzheimer's disease (AD). Methods We included healthy control subjects (N = 254), mild cognitive impairment 41), AD dementia 31) patients. Participants underwent a lumbar puncture 3 T magnetic resonance imaging. Healthy were classified following National Institute on Aging‐Alzheimer's Association stages (stage 0, N 220; stage 1, 25; 2/3, 9). assessed the cortical MD, FW,...
Abstract Background GOIZ ZAINDU (“caring early” in Basque) is a pilot study to adapt the Finnish Geriatric Intervention Study Prevent Cognitive Impairment and Disability (FINGER) methodology Basque population evaluate feasibility adherence FINGER-like multidomain intervention program. Additional aims included assessment of efficacy on cognition data collection design large trial. Method 1-year, randomized, controlled trial persons aged 60+ years, with Cardiovascular Risk Factors, Aging...
To investigate the cognitive profile of healthy individuals with increased Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score to explore whether this association is related vascular burden CSF biomarkers amyloidosis neurodegeneration.Cognitively normal participants (mean age 57.6 years) from Gipuzkoa Alzheimer Project study were classified as having high (HR; n = 82) or low (LR; 293) for according a CAIDE cutoff 9. Cognitive composites compared between groups. We...
Abstract Introduction Amyloid plaque deposition in the brain is an early pathological change Alzheimer's disease (AD), causing disrupted synaptic connections. Brain network disruptions AD have been demonstrated with eigenvector centrality (EC), a measure that identifies central regions within networks. Carrying apolipoprotein (APOE)‐ε4 allele genetic risk for AD, associated increased amyloid deposition. We studied whether APOE‐ε4 carriership EC cognitively normal individuals. Methods A total...
Alzheimer’s disease is a progressive neurodegenerative disorder, the early detection of which crucial for timely intervention and enrollment in clinical trials. However, preclinical diagnosis encounters difficulties with gold-standard methods. The current definitive still relies on expensive instrumentation post-mortem histological examinations. Here, we explore label-free Raman spectroscopy machine learning as an alternative to diagnosis. A special feature this study inclusion patient...
Background:Abnormal cholesterol metabolism changes the neuronal membrane and may promote amyloidogenesis. Oxysterols in cerebrospinal fluid (CSF) are related to Alzheimer’s disease (AD) biomarkers mild cognitive impairment dementia. Cholesterol turnover is important for axonal white matt er (WM) microstructure maintenance. Objective:We aim demonstrate that association of oxysterols, AD biomarkers, WM occurs early asymptomatic individuals. Methods:We studied inter-individual variability CSF...
Brief cognitive tests (BCT) are used in primary care (PC) for the detection of impairment (CI). Still, there little data on their diagnostic utility (DU) a community setting. This work evaluates DU at population level Fototest, [email protected], AD8 questionnaire and MMSE. It provides new cut-off points (CoP) validated CI early program. In validation samples, evaluation was carried out two phases, first screening administration BCT second clinical diagnosis, blinded to results BCT, applying...
Abstract Background Sex and gender affect Alzheimer’s Dementia differently. Some studies show that women are diagnosed at a later stage. This represents an essential challenge for healthcare makes research challenging as biases may impact participant selection clinical trials. We examined recruitment the CITA GO‐ON trial, lifestyle intervention trial to prevent cognitive decline. Method The study (ClinicalTrials.gov, NCT04840030) is population‐based randomized aims evaluate effectiveness of...
Background: Down syndrome (DS) is the most common genetically determined intellectual disability. In recent decades, it has experienced an exponential increase in life expectancy, leading to a rise age-related diseases, including Alzheimer’s disease (AD). Specific health plans for comprehensive care of DS community are unmet need, which crucial early and accurate diagnosis main medical comorbidities. We present protocol newly created clinical research cohort its feasibility real life....