Anika Finze
A5071717126- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Advanced Neuroimaging Techniques and Applications
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Advanced MRI Techniques and Applications
- Cerebrovascular and Carotid Artery Diseases
- Medical Imaging Techniques and Applications
- Neurological Disease Mechanisms and Treatments
- Genetic Neurodegenerative Diseases
- Acute Ischemic Stroke Management
- Single-cell and spatial transcriptomics
- Radiopharmaceutical Chemistry and Applications
- Intracerebral and Subarachnoid Hemorrhage Research
- Neuroscience and Neuropharmacology Research
- Olfactory and Sensory Function Studies
- Neurological disorders and treatments
Ludwig-Maximilians-Universität München
2020-2024
LMU Klinikum
2020-2024
German Center for Neurodegenerative Diseases
2023
Munich Cluster for Systems Neurology
2023
Leipzig University
2023
University of Sheffield
2023
Imperial College London
2023
University of Regensburg
2023
Abstract Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. assumed to spread prion-like across connected neurons, but mechanisms tau propagation are largely elusive characterized not only by also astroglial oligodendroglial accumulation. Here, we assess whether connectivity associated with 4R-tau deposition patterns combining resting-state fMRI connectomics both 2 nd generation 18...
Abstract Background Corticobasal syndrome is associated with cerebral protein aggregates composed of 4‐repeat (~50% cases) or mixed 3‐repeat/4‐repeat tau isoforms (~25% nontauopathies cases). Objectives The aim this single‐center study was to investigate the diagnostic value PET‐ligand [ 18 F]PI‐2620 in patients corticobasal syndrome. Methods Forty‐five (71.5 ± 7.6 years) and 14 age‐matched healthy controls underwent F]PI‐2620‐PET. Beta‐amyloid status determined by β‐amyloid PET and/or CSF...
Objective Alzheimer disease (AD) is characterized by amyloid β (Aβ) plaques and neurofibrillary tau tangles, but increasing evidence suggests that neuroinflammation also plays a key role, driven the activation of microglia. Aβ pathology appear to spread along pathways highly connected brain regions, it remains elusive whether microglial follows similar distribution pattern. Here, we assess connectivity associated with microglia patterns. Methods We included 32 Aβ‐positive early AD subjects...
Abstract Background and objectives 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation Alzheimer’s disease (AD) research. Sex obesity effects on TSPO-PET binding have been reported cognitively normal humans (CN), but such not yet systematically evaluated patients with AD. Thus, we aimed to investigate the impact sex relationship between β-amyloid-accumulation microglial activation Methods 49 AD (29 females, all...
β-amyloid (Aβ) and tau aggregation as well neuronal injury atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), biomarkers for these have been linked to neuroinflammation. However, detailed regional associations with microglial activation in individual patients remain be elucidated. We investigated a cohort 55 AD primary tauopathies 10 healthy controls that underwent TSPO-, Aβ-, tau-, perfusion-surrogate-PET, structural MRI. Z-score deviations 246 brain regions were calculated...
ABSTRACT Background Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4‐repeat tauopathies. Objectives The aim of this cross‐sectional study was to investigate 18 kDa translocator protein positron emission tomography (PET) biomarker for microglial activation the tauopathies corticobasal degeneration and progressive supranuclear palsy. Methods Specific binding tracer F‐GE‐180 determined by serial PET during pharmacological...
Dynamic 60-min positron emission tomography (PET) imaging with the novel tau radiotracer [
In recent years in vivo visualization of tau deposits has become possible with various PET radiotracers. The tracer [18F]PI-2620 proved high affinity both to 3-repeat/4-repeat Alzheimer's disease as well 4-repeat progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS). However, be clinically relevant, biomarkers should not only correlate pathological changes but also stage progression. Therefore, we aimed investigate the correlation between topology uptake symptomatology...
Abstract Purpose We hypothesized that severe tau burden in brain regions involved direct or indirect pathways of the basal ganglia correlate with more striatal dopamine deficiency four-repeat (4R) tauopathies. Therefore, we correlated [ 18 F]PI-2620 tau-positron-emission-tomography (PET) imaging 123 I]-Ioflupane single-photon-emission-computed tomography (SPECT) for transporter (DaT) availability. Methods Thirty-eight patients clinically diagnosed 4R-tauopathies (21 male; 69.0 ± 8.5 years)...
Corticobasal syndrome (CBS) with underlying 4-repeat tauopathy is a progressive neurodegenerative disease characterized by declining cognitive and motor functions. Biomarkers for assessing pathologic brain changes in CBS including tau-PET, 18 kDa translocator protein (TSPO)-PET, structural MRI, neurofilament light chain (NfL), or glial fibrillary acidic (GFAP) have recently been evaluated differential diagnosis staging, yet their association trajectories remains unclear. Therefore, we...
Abstract Objective The aim of this cross-sectional single center study was to investigate 18kDa translocator protein (TSPO)-PET as a biomarker for microglial activation in the 4-repeat tauopathies corticobasal degeneration and progressive supranuclear palsy (PSP). Methods Specific binding TSPO tracer 18 F-GE-180 determined by serial PET during pharmacological depletion microglia tau mouse model. TSPO-PET performed 30 patients with syndrome (CBS, 68±9 years, 16 female) 14 PSP (69±9 8 female),...
ABSTRACT Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies (4RT), including cortico-basal degeneration and progressive supranuclear palsy (PSP). assumed to spread prion-like across connected neurons, but mechanisms tau propagation are largely elusive 4RTs, characterized not only by also astroglial oligodendroglial accumulation. Here, we assessed whether connectivity drives 4R-tau spreading patterns combining resting-state fMRI connectomics with both 2 nd...
Abstract Background The pathology of Corticobasal syndrome (CBS) is characterized by 4‐repeat (4R)‐tau aggregation in Degeneration (CBD) and Progressive Supranuclear Palsy (PSP) ∼50%, or (3/4R)‐tau Alzheimer’s disease (AD) ∼25% patients. second generation tau‐PET ligand 18 F‐PI2620 showed high affinity to 3/4R‐tau AD also revealed 4R‐tau pathology. aim this study was investigate patients with CBS that are part the interdisciplinary “Activity Cerebral Networks, Amyloid Microglia Aging...
Abstract Background Cortico‐basal degeneration (CBD) and progressive supranuclear palsy (PSP) are 4R‐tauopathies characterized by tau pathology spread that typically starts in the subcortex. Pre‐clinical studies suggest spreads across connected neurons an activity‐dependent manner, indicating brains’ connectome may mediate spreading. Supporting this, we found Alzheimer’s disease PET‐assessed cortical functionally regions. Here, assessed whether connectivity mediates cortical/subcortical...
Abstract PurposeDynamic 60-minute positron-emission-tomography (PET) imaging with the novel tau radiotracer [ 18 F]PI-2620 facilitated accurate discrimination between patients progressive supranuclear palsy (PSP) and healthy controls (HCs). This study investigated if truncated acquisition static time windows can be used for tau-PET of PSP. MethodsThirty-seven PSP Richardson syndrome (PSP-RS) were evaluated together ten HCs. PET was performed by a dynamic 60 minute scan. Distribution volume...
ABSTRACT β-amyloid (Aβ) and tau aggregation as well neuronal injury atrophy (ATN) are the major hallmarks of Alzheimer’s disease (AD), biomarkers for these have been linked to neuroinflammation. However, detailed regional associations with microglial activation in individual patients remain be elucidated. We investigated a cohort 55 AD primary tauopathies 10 healthy controls that underwent TSPO-, A-, tau-, perfusion-surrogate-PET, structural MRI. Z-score deviations 246 brain regions were...
Abstract Background and Objectives: 18-kDa translocator protein position-emission-tomography (TSPO-PET) imaging emerged for in vivo assessment of neuroinflammation Alzheimer’s disease (AD) research. Sex obesity effects on TSPO-PET binding have been reported cognitively normal humans (CN), but such not yet systematically evaluated patients with AD. Thus, we aimed to investigate the impact sex relationship between β-amyloid-accumulation microglial activation Methods: 49 AD (29 females, all...
Abstract Background Corticobasal syndrome (CBS) with underlying 4‐repeat tauopathy is a progressive neurodegenerative disorder characterized by declining cognitive and motor functions. Biomarkers for assessing pathological brain changes in CBS including tau‐ microglia‐PET or neurofilament light chain (NfL) have recently been evaluated differential diagnosis disease staging, yet the prognostic accuracy of these biomarkers predicting trajectories remains unclear. To address this, we performed...
This is a cross-sectional study to evaluate whether β-amyloid-(Aβ)-PET positivity and cortical superficial siderosis (cSS) in patients with cerebral amyloid angiopathy (CAA) are regionally colocalized.Ten probable or possible CAA (73.3 ± 10.9 years, 40% women) underwent MRI examination gradient-echo-T2*-weighted-imaging sequence detect cSS 18F-florbetaben PET fibrillar Aβ. In all regions of the Hammers Atlas, (MRI: ITK-SNAP segmentation) Aβ-PET (PET: ≥ mean value + 2 standard deviations 14...
Background: Alzheimer′s disease (AD) is characterized by amyloid-β; (Aβ) plaques, neurofibrillary tau tangles and neuroinflammation leading to brain functional connectivity changes cognitive decline. There evidence, that microglial activity increased in AD Aβ pathology appear spread along pathways of highly connected regions, but it remains elusive if activation follows a similar distribution pattern. Methods: Thirty-two early subjects 18 age-matched healthy cognitively normal controls were...
Abstract Background 18‐kDa translocator protein position‐emission‐tomography (TSPO‐PET) imaging emerged for in vivo assessment of neuroinflammation preclinical and clinical research Alzheimer’s disease (AD). Higher TSPO‐PET binding as a surrogate microglial activation females has been reported cognitively normal humans (HC), but sex effects have not yet systematically evaluated patients with AD. Thus, we aimed to investigate the impact body mass index (BMI) on relationship between...
Abstract Background Dynamic 60‐minute positron‐emission‐tomography (PET) imaging with the novel tau radiotracer [ 18 F]PI‐2620 facilitated accurate discrimination between patients progressive supranuclear palsy (PSP) and healthy controls (HCs). We now aimed to investigate if shorter acquisition static time windows of tau‐PET can be used for PSP. Method evaluated 37 at five different centers probable or possible PSP Richardson syndrome (PSP‐RS) together ten HCs. PET was performed by a dynamic...