A5076140990- Functional Brain Connectivity Studies
- Advanced Neuroimaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Alzheimer's disease research and treatments
- EEG and Brain-Computer Interfaces
- Medical Imaging Techniques and Applications
- Mental Health Research Topics
- Neuroinflammation and Neurodegeneration Mechanisms
- Dementia and Cognitive Impairment Research
- Inflammation biomarkers and pathways
- Peripheral Nerve Disorders
- Neurological Disease Mechanisms and Treatments
- Lanthanide and Transition Metal Complexes
- Neuroscience and Neural Engineering
- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Bioinformatics and Genomic Networks
- Frailty in Older Adults
- Atomic and Subatomic Physics Research
- MRI in cancer diagnosis
- Transcranial Magnetic Stimulation Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Neuroscience and Music Perception
- S100 Proteins and Annexins
Ludwig-Maximilians-Universität München
2020-2025
LMU Klinikum
2020-2025
University Medical Center Hamburg-Eppendorf
2023-2025
Universität Hamburg
2023-2025
Abstract Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies, including cortico-basal degeneration and progressive supranuclear palsy. assumed to spread prion-like across connected neurons, but mechanisms tau propagation are largely elusive characterized not only by also astroglial oligodendroglial accumulation. Here, we assess whether connectivity associated with 4R-tau deposition patterns combining resting-state fMRI connectomics both 2 nd generation 18...
In Alzheimer’s disease, PET-assessed tau pathology emerges locally and spreads throughout functionally connected regions.
Abstract Cognitive resilience is an important modulating factor of cognitive decline in Alzheimer’s disease, but the functional brain mechanisms that support remain elusive. Given previous findings normal ageing, we tested hypothesis higher segregation brain’s connectome into distinct networks represents a mechanism underlying disease. Using resting-state MRI, assessed both MRI global system segregation, i.e. balance between-network to within-network connectivity, and alternate index...
Abstract In Alzheimer’s disease (AD), younger symptom onset is associated with accelerated progression and tau spreading, yet the mechanisms underlying faster manifestation are unknown. To address this, we combined resting-state fMRI longitudinal tau-PET in two independent samples of controls biomarker-confirmed AD patients (ADNI/BioFINDER, n = 240/57). Consistent across both samples, found that symptomatic showed stronger globally connected fronto-parietal hubs, i.e., regions critical for...
Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson's disease but also one of the most common co-pathologies Alzheimer's (AD). Preclinical studies suggest that αSyn can exacerbate tau aggregation, implying co-pathology may specifically contribute to Aβ-induced aggregation drives neurodegeneration and cognitive decline AD. To investigate this, we combined novel CSF-based seed-amplification assay (SAA) determine positivity with amyloid- tau-PET neuroimaging large cohort...
Abstract Background The Apolipoprotein E ε4 allele (i.e. ApoE4) is the strongest genetic risk factor for sporadic Alzheimer’s disease (AD). TREM2 Triggering receptor expressed on myeloid cells 2) a microglial transmembrane protein brain that plays central role in microglia activation response to AD pathologies. Whether higher TREM2-related activity modulates develop clinical an open question. Thus, aim of current study was assess whether sTREM2 attenuates effects ApoE4-effects future...
Adults with Down Syndrome (DS) have a substantially increased risk for Alzheimer's disease (AD) due to the triplicated amyloid-precursor-protein gene on chromosome 21, resulting in amyloid and tau accumulation. However, PET assessments are not sufficiently implemented DS-AD research or clinical work-up, second-generation tracers such as [18F]PI-2620 been thoroughly characterized adults DS. We aim at illustrating feasibility potential diagnostic value of imaging diagnosis DS-AD. Five DS (40%...
Abstract Motor cortical high‐gamma oscillations (60–90 Hz) occur at movement onset and are spatially focused over the contralateral primary motor cortex. Although widely recognized for their significance in human control, precise function on a level remains elusive. Importantly, relevance stroke pathophysiology is unknown. Because deficits fundamental determinants of symptom burden after stroke, understanding neurophysiological processes coding could be an important step improving...
Abstract Patients with Alzheimer’s disease (AD) and clinically overlapping neurodegenerative diseases are classified molecularly using the A/T/N classification system. Apart from fluid biomarkers structural MRI, three-dimensional system incorporates characteristic features β-amyloid-PET (A), tau-PET (T), FDG-PET (N). We evaluated if dynamic of [ 18 F]PI-2620 allow assessment in individual patients a single imaging session. Cortical tissue clearance (K2a) was validated as surrogate β-amyloid...
Ziel/Aim: Die progressive supranukleäre Blickparese (PSP) und die kortikobasale Degeneration (CBD), zwei primäre 4-Repeat-Tauopathien (4RT), können mit Tau-PET-Bildgebung unter Verwendung des Radiotracers der zweiten Generation [18F] PI-2620 nachgewiesen werden. Im Gegensatz zur Alzheimer-Krankheit (AD) wurde Nutzen sequentiellen PI-2620-Bildgebung Verfolgung Krankheitsverlaufs jedoch noch nicht untersucht.
Abstract Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent studies indicated relevant of novel tau tracers to melanin-containing structures. To date, little is known about the effect melanocytes meninges on tracer signals brain PET data. Thus, we aimed identify target structure causal for frequently observed [ 18 F]PI-2620 signal vermis...
The indication for mechanical thrombectomy (MT) in stroke patients with large vessel occlusion has been constantly expanded over the past years. Despite remarkable treatment effects at group level clinical trials, many remain severely disabled even after successful recanalization. A better understanding of this outcome variability will help to improve decision-making on MT acute stage. Here, we test whether current models can be refined by integrating information preservation corticospinal...
Abstract Motor cortical high-gamma oscillations (60 to 90 Hz) occur at the onset of movement and are spatially focused over contralateral primary motor cortex. Although widely recognized for their significance in human control, precise function on a level remains elusive. Importantly, relevance stroke pathophysiology is unknown. Understanding neurophysiological processes coding could be an important step improving recovery after stroke. We recorded magnetoencephalography data during thumb...
Structural disconnectome analyses have provided valuable insights into how a stroke lesion results in widespread network disturbances and these relate to deficits, recovery patterns, outcome. Previous primarily focused on patients with relatively mild moderate deficits. However, outcomes vary among survivors of severe strokes, the mechanisms remain poorly understood. This study assesses association between lesion-induced disconnection outcome after stroke. Thirty-eight ischaemic underwent...
White matter hyperintensities of presumed vascular origin (WMH), a manifestation cerebral small vessel disease, are associated with various clinical sequelae. In stroke patients, total WMH burden is linked to recurrent cerebrovascular events and worse outcome. As also affect the integrity structural large-scale brain networks, we hypothesize that extent WMH-related network damage carries relevant information explain outcome variability in addition global volume. Clinical imaging data 33...
The concept of brain reserve capacity has emerged in stroke recovery research recent years. Imaging-based biomarkers health have helped to better understand outcome variability clinical cohorts. Still, inferences are far from being satisfactory, particularly patients with severe initial deficits. Neurorehabilitation after is a complex process, comprising adaption and learning processes, which, on their part, critically influenced by motivational reward-related cognitive processes. Amongst...
Abstract Characterizing cortical plasticity becomes increasingly important for identifying compensatory mechanisms and structural reserve in the ageing population. While thickness (CT) largely contributed to systems neuroscience, it incompletely informs about underlying neuroplastic pathophysiology. In turn, microstructural characteristics may correspond atrophy a more sensitive way. Fractional anisotropy, diffusion tensor imaging (DTI) measure, is inversely related histologic complexity....
ABSTRACT Structural disconnectome analyses have provided valuable insights into how a stroke lesion results in widespread network disturbances and these relate to deficits, recovery patterns, outcomes. Previous primarily focused on patients with relatively mild moderate deficits. However, outcomes vary among survivors of severe strokes, the mechanisms remain poorly understood. This study assesses association between lesion‐induced disconnection outcome after stroke. Thirty‐eight ischaemic...
Abstract Background In Alzheimer’s disease (AD), tau pathology spreads from the temporal lobe throughout brain, ensuing cognitive decline. PET‐assessed tau‐spreading patterns are, however, heterogeneous across patients, posing challenges for assessing patient‐specific or group‐level longitudinal tau‐changes. Yet, this may become critical management and evaluating tau‐targeting treatments. Using tau‐PET resting‐state fMRI, we reported previously that preferentially functionally connected...
ABSTRACT Tau pathology is the main driver of neuronal dysfunction in 4-repeat tauopathies (4RT), including cortico-basal degeneration and progressive supranuclear palsy (PSP). assumed to spread prion-like across connected neurons, but mechanisms tau propagation are largely elusive 4RTs, characterized not only by also astroglial oligodendroglial accumulation. Here, we assessed whether connectivity drives 4R-tau spreading patterns combining resting-state fMRI connectomics with both 2 nd...
Abstract Background Global connectivity of the left frontal cortex (LFC), a hub cognitive control network, is associated with higher fluid intelligence and relatively preserved cognition despite age‐ Alzheimer’s disease (AD)‐related brain changes, rendering LFC‐connectivity candidate substrate reserve (Franzmeier et al. Brain 2018). Yet, mechanisms by which supports at functional network level remain unclear. Functional network‐segregation within guards against diffuse organization...
Abstract Characterizing cortical plasticity becomes increasingly important for identifying compensatory mechanisms and structural reserve in the aging population. While thickness (CT) largely contributed to systems neuroscience, it incompletely informs about underlying neuroplastic pathophysiology. In turn, microstructural characteristics may correspond atrophy a more sensitive way, indicating potentially necessary paradigm shift neuroimaging. Fractional anisotropy (FA), diffusion tensor...