A5001171995- Alzheimer's disease research and treatments
- Medical Imaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- Parkinson's Disease Mechanisms and Treatments
- Bacterial Identification and Susceptibility Testing
- Antimicrobial Resistance in Staphylococcus
- Immunotherapy and Immune Responses
- Neuroblastoma Research and Treatments
- Amino Acid Enzymes and Metabolism
- Medical Imaging and Pathology Studies
- Streptococcal Infections and Treatments
- CAR-T cell therapy research
- Dementia and Cognitive Impairment Research
- Trace Elements in Health
- Radiopharmaceutical Chemistry and Applications
- Mycobacterium research and diagnosis
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Innovations in Medical Education
- Diphtheria, Corynebacterium, and Tetanus
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Treatments and Mutations
- Escherichia coli research studies
- Neurological diseases and metabolism
- Genetic Neurodegenerative Diseases
University of Tübingen
1975-2024
Siemens (Germany)
2015-2024
Ludwig-Maximilians-Universität München
1964-2023
LMU Klinikum
2020-2023
Munich Cluster for Systems Neurology
2023
German Center for Neurodegenerative Diseases
2023
Leipzig University
2023
University of Sheffield
2023
Imperial College London
2023
University of Regensburg
2023
Abstract The biological nitrogen cycle is driven by a plethora of reactions transforming compounds between various redox states. Here, we investigated the metagenomic potential for in situ microbial community an oligotrophic, brackish environment Bothnian Sea sediment. Total DNA from three sediment depths was isolated and sequenced. characterization total performed based on 16S rRNA gene inventory using SILVA database as reference. diversity diagnostic functional genes coding nitrate...
β-amyloid (Aβ) and tau aggregation as well neuronal injury atrophy (ATN) are the major hallmarks of Alzheimer's disease (AD), biomarkers for these have been linked to neuroinflammation. However, detailed regional associations with microglial activation in individual patients remain be elucidated. We investigated a cohort 55 AD primary tauopathies 10 healthy controls that underwent TSPO-, Aβ-, tau-, perfusion-surrogate-PET, structural MRI. Z-score deviations 246 brain regions were calculated...
Stimulating the immune system to attack cancer is a promising approach, even for control of advanced cancers. Several cytokines that promote interferon-γ-dominated responses show antitumor activity, with interleukin 12 (IL-12) being major importance. Here, we used an antibody-IL-12 fusion protein (NHS-IL12) binds histones necrotic cells treat human sarcoma in humanized mice. Following engraftment, NHS-IL12 therapy was combined either engineered IL-7 (FcIL-7) or IL-2 (IL-2MAB602) continuous...
ABSTRACT Background Neuroinflammation has received growing interest as a therapeutic target in neurodegenerative disorders, including 4‐repeat tauopathies. Objectives The aim of this cross‐sectional study was to investigate 18 kDa translocator protein positron emission tomography (PET) biomarker for microglial activation the tauopathies corticobasal degeneration and progressive supranuclear palsy. Methods Specific binding tracer F‐GE‐180 determined by serial PET during pharmacological...
TSPO-PET tracers are sensitive to a single-nucleotide polymorphism (rs6971-SNP), resulting in low-, medium- and high-affinity binders (LABs, MABs HABS), but the clinical relevance of [18F]GE-180 is still unclear. We evaluated impact rs6971-SNP on vivo binding healthy brain pseudo-reference tissue neuro-oncological neurodegenerative diseases. Standardized uptake values (SUVs) [18F]GE-180-PET were assessed using manually drawn region interest frontoparietal cerebellar hemispheres. The SUVs...
Background: Antibodies targeting surface expressed disialoganglioside GD2 are increasingly used in neuroblastoma immunotherapy and might also have potential for use radioimmunotherapy.As such targeted treatments benefit from a dedicated theranostic approach, we studied the influence of radiolabeling on binding characteristics ch14.18 antibodies produced by Chinese hamster ovary (CHO) cells evaluated GD2-ImmunoPET as tool therapy planning.Methods: 64 Cu was to reduce radiation burden, which...
Objectives: In recent years several 18 F-labeled amyloid PET (Aβ-PET) tracers have been developed and obtained clinical approval. There is evidence that Aβ-PET perfusion can provide surrogate information about neuronal injury in neurodegenerative diseases when compared to conventional blood flow glucose metabolism assessment. However, this paradigm has not yet tested disorders with cortical subcortical affection. Therefore, we investigated the performance of early acquisition F-flutemetamol...
Staphylococcus aureus is a major human pathogen and common cause of nosocomial infections. This facultative produces large arsenal virulence factors, including the haemolysins, which allow bacterium to lyse erythrocytes thereby release amounts haem-containing haemoglobin. The released haem thought be main iron source this organism during course infection, considered crucial for bacterial proliferation in vivo. High concentrations its degradation products, on other hand, are known toxic S....
Corticobasal syndrome (CBS) with underlying 4-repeat tauopathy is a progressive neurodegenerative disease characterized by declining cognitive and motor functions. Biomarkers for assessing pathologic brain changes in CBS including tau-PET, 18 kDa translocator protein (TSPO)-PET, structural MRI, neurofilament light chain (NfL), or glial fibrillary acidic (GFAP) have recently been evaluated differential diagnosis staging, yet their association trajectories remains unclear. Therefore, we...
The natural phytoestrogen genistein is known as protein kinase inhibitor and tumor suppressor in various types of cancers. We studied its antitumor effect two different xenograft models using positron emission tomography (PET) vivo combined with ex histology nuclear magnetic resonance (NMR) metabolic fingerprinting.A431 Colo205 tumor-bearing mice were treated vehicle or (500 mg/kg/d) over a period 12 days. Imaging was performed 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG)...
Antibody-based therapies gain momentum in clinical therapy, thus the need for accurate imaging modalities with respect to target identification and therapy monitoring are of increasing relevance. Cerenkov luminescence (CLI) a novel method detecting charged particles emitted during radioactive decay optical imaging. Here, we compare Position Emission Tomography (PET) CLI multimodal study aiming at fast efficient screening monoclonal antibodies (mAb) designated targeting...
Abstract Objective The aim of this cross-sectional single center study was to investigate 18kDa translocator protein (TSPO)-PET as a biomarker for microglial activation in the 4-repeat tauopathies corticobasal degeneration and progressive supranuclear palsy (PSP). Methods Specific binding TSPO tracer 18 F-GE-180 determined by serial PET during pharmacological depletion microglia tau mouse model. TSPO-PET performed 30 patients with syndrome (CBS, 68±9 years, 16 female) 14 PSP (69±9 8 female),...
Abstract The inner clock of biological organisms plays a pivotal role and has strong effects on metabolic processes such as glucose consumption. Since the commonly used positron emission tomography (PET) tracer 18 F-flourodeoxygucose (FDG) is analogue, it not surprising that FDG distribution in mice humans been shown to succumb daily rhythms. In preclinical studies, circadian rhythm animals often considered, studies are performed at different times day. Only few have analyzed effect uptake...
TSPO-PET tracers are sensitive to a single-nucleotide-polymorphism (rs6971-SNP) resulting in low (LAB), medium (MAB) and high (HAB) affinity binders, but the clinical relevance for [18F]GE-180 is still unclear. We evaluate impact of rs6971-SNP on vivo binding healthy brain pseudo-reference tissue neurooncological neurodegenerative diseases. Standardized uptake values (SUV) [18F]GE-180-PET were assessed using manually drawn region interest fronto-parietal cerebellar hemisphere. SUVs compared...