A5035884358- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- MRI in cancer diagnosis
- Prostate Cancer Treatment and Research
- Advanced MRI Techniques and Applications
- Advanced X-ray and CT Imaging
- Hepatocellular Carcinoma Treatment and Prognosis
- Sarcoma Diagnosis and Treatment
- Prostate Cancer Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Cancer Diagnosis and Treatment
- Medical Imaging and Pathology Studies
- Radiopharmaceutical Chemistry and Applications
- Renal cell carcinoma treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Head and Neck Cancer Studies
- Multiple Myeloma Research and Treatments
- Cytokine Signaling Pathways and Interactions
- Parasitic infections in humans and animals
- Atomic and Subatomic Physics Research
- Cancer Immunotherapy and Biomarkers
- Lung Cancer Treatments and Mutations
- Lymphoma Diagnosis and Treatment
- Systemic Sclerosis and Related Diseases
- Neuroendocrine Tumor Research Advances
University Hospital Ulm
2018-2025
Klinik und Poliklinik für Nuklearmedizin
2020-2025
Universität Ulm
2021-2024
University of Tübingen
2014-2023
Medical University of Vienna
2023
Siemens (Germany)
2014-2020
Universitätsklinikum Tübingen
2015-2020
Johns Hopkins University
2016-2018
Victor Babeș University of Medicine and Pharmacy Timișoara
2018
Kiel University
2010-2011
IL-6 trans-signaling via the soluble receptor (sIL-6R) plays a critical role in chronic inflammation and cancer. Soluble gp130 (sgp130) specifically inhibits but was described to not interfere with classic signaling membrane-bound IL-6R. Physiological most pathophysiological conditions are characterized by molar excess of serum sIL-6R over free found IL-6·sIL-6R complexes allowing both trans-signaling. Surprisingly, under these conditions, sgp130 able trap all molecules IL-6·sIL-6R·sgp130...
Combined PET and MR imaging (PET/MR imaging) has progressed tremendously in recent years. The focus of current research shifted from technologic challenges to the application this new multimodal technology areas oncology, cardiology, neurology, infectious diseases. This article reviews studies preclinical clinical translation. common theme these initial results is complementary nature combined PET/MR that often provides additional insights into biologic systems were not clearly feasible with...
As technical developments in omics and biomedical imaging increase the throughput of data generation life sciences, need for information systems capable managing heterogeneous digital assets is increasing. In particular, supporting findability, accessibility, interoperability, reusability (FAIR) principles scientific management.We propose a Service Oriented Architecture approach integrated management analysis multi-omics data. Our architecture introduces an image system into FAIR-supporting,...
Mantle cell lymphoma (MCL) is a rare lymphoid malignancy with poor prognosis characterised by frequent relapse and short durations of treatment response. Most patients present aggressive disease, but there exist indolent subtypes without the need for immediate intervention. The very heterogeneous behaviour MCL genetically translocation t(11;14)(q13;q32), leading to Cyclin D1 overexpression distinct clinical biological characteristics outcomes. There still an unfulfilled precise...
Li-Fraumeni syndrome (LFS) is an autosomal dominant tumor predisposition characterized by a high familial incidence of various malignancies. It results from pathogenic/likely pathogenic heterozygous constitutional variants the TP53 gene. Due to impaired DNA damage repair, conventional cytotoxic therapies or radiotherapy should be avoided whenever feasible mitigate treatment-related secondary malignancies in these patients. However, there limited evidence supporting effectiveness targeted...
Ziel/Aim: Als eine gängige Methode zur Beurteilung und Messung von Entzündungsaktivitäten hat sich die F-18-FDG-PET/CT bereits etabliert. Zur Detektion Diagnostik Wundheilungsstörungen bei traumatischem Frakturgeschehen wird sie jedoch in der klinischen Routine nicht standardmäßig eingesetzt. Ziel dieser Arbeit ist es, diagnostische sowie prognostische Relevanz nachzuweisen bildgebende Marker aufzuzeigen.
Abstract During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to nucleus activate expression Ucp1 and Pgc-1α . The mechanisms underlying ATF2 target activation are unknown. Here we demonstrate that p62 (Sqstm1) binds orchestrate enhancer promoter. P62 Δ69-251 mice show reduced with impaired genomic binding. Modulation through regulation signaling is demonstrated in vitro vivo mice, global −/−...
Objectives. The aim of this study was to evaluate the course SSc-related pulmonary abnormalities following high-dose chemotherapy with autologous stem cell transplantation (SCT) by quantitative chest CT analysis and compare results those function tests response cutaneous involvement.
Purpose of this study is to evaluate the diagnostic accuracy quantitative T2/ADC values in differentiating between PCa and lesions showing non-specific inflammatory infiltrates atrophy, features chronic prostatitis, as most common histologically proven differential diagnosis.In retrospective, single-center cohort study, we analyzed 55 patients suspected PCa, who underwent mpMRI (3T) including T2 maps before robot-assisted mpMRI-TRUS fusion prostate biopsy. All were scored according PI-RADS...
Abstract Objectives To develop and test a Retina U-Net algorithm for the detection of primary lung tumors associated metastases all stages on FDG-PET/CT. Methods A data set consisting 364 FDG-PET/CTs patients with histologically confirmed cancer was used development internal testing. The comprised stages. All (T), lymphatic (N), distant (M) were manually segmented as 3D volumes using whole-body PET/CT series. split into training ( n = 216), validation 74), 74). Detection performance lesion...
Pulmonary involvement is common in several infectious and non-infectious diagnostic settings. Imaging findings consistently overlap are therefore difficult to differentiate by chest-CT. The aim of this study was evaluate the role CT-textural features(CTTA) for discrimination between atypical viral (respiratory-syncitial-virus(RSV) herpes-simplex-1-virus (HSV1)), fungal (pneumocystis-jirovecii-pneumonia(PJP)) interstitial pneumonias alveolar hemorrhage. By retrospective single-centre analysis...
Accurate prediction of lymph node metastasis (LNM) in patients with testicular cancer is highly relevant for treatment decision-making and prognostic evaluation. Our study aimed to develop validate clinical radiomics models individual preoperative LNM cancer. We enrolled 91 clinicopathologically confirmed early-stage cancer, disease confined the testes. included five significant risk factors (age, serum tumour markers AFP B-HCG, histotype BMI) build model. After segmenting 273...
Background Implantation of a transjugular intrahepatic portosystemic shunt (TIPS) induces changes liver perfusion. Purpose To determine the in arterial, portal venous, and total perfusion parenchyma induced by TIPS using technique volume computed tomography (VPCT) compare results with invasively measured hepatic intravascular pressure values. Material Methods VPCT quantification was performed 23 patients (mean age, 62.5 ± 8.8 years) hypertension pre-TIPS post-TIPS setting, respectively. A...
Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer of the elderly, with high metastatic potential and poor prognosis. In particular, primary resistance to immune checkpoint inhibitors (ICI) in (m)MCC patients represents challenge not yet met by any efficient treatment modality. Herein, we describe novel therapeutic concept short-interval, low-dose 177Lutetium (Lu)-high affinity (HA)-DOTATATE [177Lu]Lu-HA-DOTATATE peptide receptor radionuclide therapy (SILD-PRRT) combination PD-1 ICI...