A5081845209- Renal cell carcinoma treatment
- Prostate Cancer Diagnosis and Treatment
- Renal and related cancers
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Pediatric Urology and Nephrology Studies
- MRI in cancer diagnosis
- Kidney Stones and Urolithiasis Treatments
- Cancer Genomics and Diagnostics
- Testicular diseases and treatments
- Epigenetics and DNA Methylation
- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Urinary and Genital Oncology Studies
- Sperm and Testicular Function
- Radiomics and Machine Learning in Medical Imaging
- Urologic and reproductive health conditions
- Healthcare and Venom Research
- Pelvic floor disorders treatments
- Drug Transport and Resistance Mechanisms
- Ferroptosis and cancer prognosis
- Cancer Immunotherapy and Biomarkers
- Multiple and Secondary Primary Cancers
- RNA Interference and Gene Delivery
- Renal and Vascular Pathologies
Siloah St. Trudpert Klinikum
2018-2024
University of Tübingen
2013-2023
University Children's Hospital Tübingen
2014-2018
Universitätsklinikum Tübingen
2013-2016
Klinik und Poliklinik für Urologie
2016
Siemens Healthcare (Germany)
2015
Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology
2013
Robert Bosch Hospital
2013
Weizmann Institute of Science
2013
Tumori Foundation
2013
Organic cation transporters (OCTs) determine not only physiological processes but are also involved in the cellular uptake of anticancer agents. Based on microarray analyses hepatocellular carcinoma (HCC), SLC22A1/OCT1 mRNA seems to be downregulated, systematic protein expression data currently missing. Moreover, underlying molecular mechanisms responsible for altered SLC22A1 HCC fully understood. Therefore, we investigated role DNA methylation transcriptional regulation family members...
Abstract By recording auditory electrical brain potentials, we investigated whether the basic sound parameters (frequency, duration and intensity) are differentially encoded among speech vs. music sounds by musicians non‐musicians during different attentional demands. To this end, a pseudoword an instrumental of comparable frequency were presented. The accuracy neural discrimination was tested manipulations frequency, intensity. Additionally, subjects’ focus manipulated instructions to...
The monocarboxylate transporter 4 (MCT4) is a metabolic target in tumor biology because it mediates lactate transport across membranes resulting antiapoptotic effects. Cell experiments support the importance of MCT4 clear cell renal carcinoma (ccRCC). In this study, we assessed prognostic potential expression ccRCC and its epigenetic regulation by DNA methylation as novel predictive marker for patient outcome using independent cohorts.MCT4 protein was quantified 207 corresponding nontumor...
In renal cell carcinoma (RCC), single members of the Wnt/β-catenin signaling cascade were recently identified to contribute cancer progression. However, role Wnt1, one key ligands in β-catenin regulation, is currently unknown RCC. Therefore, alterations Wnt1/β-catenin axis clear RCC (ccRCC) examined with regard clinicopathology, overall survival (OS) and specific (CSS). Corresponding ccRCCs benign tissue analyzed 278 patients for Wnt1 expression by immunohistochemistry microarrays....
Abstract Testicular germ cell tumors (TGCT) are considered a paradigm of chemosensitive tumors. Embryonal carcinoma cells represent the pluripotent entity TGCTs and characterized by expression Oct-4, key regulator pluripotency determinant their inherent hypersensitivity to cisplatin. However, mechanisms underlying this Oct-4–mediated sensitivity poorly understood. We previously showed that p53 is major player in cisplatin therefore investigated whether Oct-4 may directly affect activity....
The efflux transporter breast cancer resistance protein BCRP/ABCG2 is well-known for its contribution to multi-drug in cancer. Its relevance biology independent from drug remains largely elusive. Our study aimed at elucidating the biological and regulatory mechanisms of clear cell renal carcinoma (ccRCC) disease progression. Two ccRCC-cohorts [Cohort 1 (KIRC/TCGA): n = 453, Cohort 2: 64] were investigated elucidate mRNA expression their association with survival. impact on response sunitinib...
The aim of this study was to assess the effect temporal resolution on semiquantitative and pharmacokinetic parameters from dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) their diagnostic accuracy regarding detection potentially malignant prostate lesions.Sixty consecutive male patients (age, 64.5 ± 7.0 years) with clinically suspected cancer were included. All underwent multiparametric MRI (T2-weighted, diffusion-weighted imaging, DCE-MRI) a 3 T scanner. Patients divided...
<i>Objectives:</i> The epidermal growth factor receptor- (EGFR) activated phosphatidylinositol 3-kinase (PI3K)/protein kinase B (PKB/Akt) pathway is associated with tumorigenesis and progression. aims of the present study were to determine expression patterns Akt parameters PI3K, phosphatase tensin homolog (PTEN), phosphor-Akt (p-Akt) their combination, for possible prognostic value in renal cell carcinoma (RCC). PTEN dephosphorylates liquid product PI3K....
<b><i>Objective:</i></b> To directly compare the diagnostic performance of targeted MRI-guided biopsy (MR-GB) and systematic transrectal ultrasound-guided (TRUS-GB). <b><i>Methods:</i></b> Thirty-five patients with at least one negative TRUS-GB, persistently elevated or rising prostate-specific antigen a lesion suspicious for prostate cancer (PC) on multiparametric MRI (mpMRI) scored by using Prostate Imaging Reporting Data System (PI-RADS)...
Abstract Current therapies for metastatic clear cell renal carcinoma (ccRCC) show limited efficacy. Drug efficacy, typically investigated in preclinical line models during drug development, is influenced by pharmacogenes involved targeting and disposition of drugs. Here we through genome-wide DNA methylation profiling, that patterns are concordant between primary ccRCC macro-metastases irrespective sites (r s ≥ 0.92). However, 195,038 (41%) all CpG sites, including within pharmacogenes, were...