A5015477233- Urological Disorders and Treatments
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Tissue Engineering and Regenerative Medicine
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Urologic and reproductive health conditions
- Urinary and Genital Oncology Studies
- Mesenchymal stem cell research
- Anorectal Disease Treatments and Outcomes
- Renal cell carcinoma treatment
- Peripheral Nerve Disorders
- Hernia repair and management
- Cancer Cells and Metastasis
- Urinary Tract Infections Management
- Pediatric Urology and Nephrology Studies
- Sexual function and dysfunction studies
- Anesthesia and Pain Management
- Renal and related cancers
- Pelvic and Acetabular Injuries
- Kidney Stones and Urolithiasis Treatments
- Genital Health and Disease
- Prostate Cancer Treatment and Research
- Medical and Health Sciences Research
University of Tübingen
2016-2025
University Children's Hospital Tübingen
2014-2025
Klinik und Poliklinik für Urologie
2024
Universitätsklinikum Tübingen
2007-2022
Tumori Foundation
2013
Kantonsspital Winterthur
2011
Hertie Institute for Clinical Brain Research
2006
Abstract Background The study aim was to investigate potential influences on human nerves and pelvic organs through early implantation of bilateral sacral nerve modulators (SNMs) in complete spinal cord injury (SCI) patients during the acute bladder‐areflexia phase. Methods Ten with neurologically‐confirmed lesions (SCLs) were provided SNMs phase atonic‐detrusor muscle. Modulation achieved by two electrodes implanted into each S 3 ‐foramen. Six declined served as controls. mean follow‐up...
Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does study add? The minimally invasive percutaneous nephrolitholapaxy (MIP) has shown high efficacy safety for management small renal stones. It was initially developed to overcome a gap between extracorporeal shockwave lithotripsy conventional (PCNL) in low stone burden but there is debate as whether MIP also effective larger present shows MIP, which comparable PCNL treatment stones >20 mm,...
Successful outcomes have been reported for the treatment of lower urinary tract symptoms (LUTS) with prostatic urethral lift (PUL) in a number clinical investigations. Our aim was to investigate PUL patients treated day-to-day setting without rigid exclusion criteria studies. We investigated outcome procedure at five German departments during initial period when approved clinic (10/2012–06/2014). All candidates transurethral resection prostate (TURP) received information and were given...
In animal models, cell therapies for different diseases or injuries have been very successful. Preclinical studies with cells aiming at a stroke, heart attack, and other emergency situations were promising but sometimes failed translation in clinical situations. We, therefore, investigated if human placenta-derived mesenchymal stromal can be injected pigs without provoking rejection to serve as xenogenic transplantation model bridge preclinical more future studies. Male isolated, expanded,...
Abstract Including sensor information in medical interventions aims to support surgeons decide on subsequent action steps by characterizing tissue intraoperatively. With bladder cancer, an important issue is tumor recurrence because of failure remove the entire tumor. Impedance measurements can help classify and give indication how much remove. Over years research, it became obvious that electrical impedance spectroscopy a very promising tool for differentiation, but also sensitive one....
Abstract Background Animals serve as important models for exploring the pathology, diagnosis, and therapy of different diseases injuries. While smaller animals are preferred bulk cohort studies, larger offer opportunities to investigate surgical procedures at proportions close human situation. Therefore, in a feasibility study, we investigated urethral sphincter deficiency German landrace gilts Göttingen minipigs develop model urinary incontinence basis future preclinical studies therapies....
The increase in multiparametric magnetic resonance imaging (mpMRI) examinations as a fundamental tool prostate cancer (PCa) diagnostics raises the need for supportive computer-aided analysis. Therefore, we evaluated performance of commercially available AI-based algorithm detection and classification multi-center setting. Representative patients with 3T mpMRI between 2017 2022 at three different university hospitals were selected. Exams read according to PI-RADSv2.1 protocol then assessed by...
Mesenchymal stromal cells (MSCs) are multipotent that can be differentiated in vitro into a variety of cell types, including adipocytes or osteoblasts. Our recent studies indicated high expression CD146 on MSCs from bone marrow correlates with their robust osteogenic differentiation potential. We therefore investigated if the placenta similar The were isolated specifically endometrial and fetal parts human term expanded separate cultures compared as controls. surface antigens was by flow...
No AccessJournal of UrologyInvestigative Urology1 Mar 2012Introducing a Large Animal Model to Create Urethral Stricture Similar Human Disease: A Comparative Experimental Microscopic Study Karl-Dietrich Sievert, Christian Selent-Stier, J. Wiedemann, T.-O. Greiner, Bastian Amend, A. Stenzl, Gerhardt Feil, and Seibold SievertKarl-Dietrich Sievert Equal study contribution. More articles by this author , Selent-StierChristian Selent-Stier WiedemannJ. Wiedemann GreinerT.-O. Greiner AmendBastian...
This study investigates the feasibility of establishing urine-derived tumor organoids from bladder cancer (BC) patients as an alternative to tissue-derived organoids. BC is one most common cancers worldwide and current diagnostic methods involve invasive procedures. Here, we investigated potential using urine samples, which contain exfoliated cells, generate (uBCOs). Urine samples 29 were collected cells isolated cultured in a three-dimensional matrix. The establishment primary expansion...
The leading cause of stress urinary incontinence in women is the urethral sphincter muscle deficiency caused by mechanical during pregnancy and vaginal delivery. In men, prostate cancer surgery injury local nerves muscles are associated with incontinence. Current treatment often fails to satisfy patient's needs. Cell therapy may improve situation. We therefore investigated regeneration potential cells ameliorating a large animal model. Urethral was induced surgically gilts electrocautery...